PKC-β exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA/Rho-kinase/MLC2 pathway

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 12, 2013, Pages 1928-1936

  Srivastava, Kirtiman ^a   Shao, Beili ^a   Bayraktutan, Ulvi ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cytoskeletal remodeling; Hyperglycemia; Protein kinase C; Rho kinase; RhoA; Tight junction

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALBUMIN; EVANS BLUE; GLUCOSE; IMMUNOGLOBULIN G; MYOSIN LIGHT CHAIN 2; OCCLUDIN; PROTEIN KINASE C BETA; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; ARTICLE; ASTROCYTE; BINDING ASSAY; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; DISEASE EXACERBATION; ELECTRIC RESISTANCE; ELECTROPORATION; ENZYME ACTIVATION; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOBLOTTING; IN VITRO STUDY; MEMBRANE DAMAGE; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION; WESTERN BLOTTING;

BLOOD-BRAIN BARRIER; CARDIAC MYOSINS; CELL LINE; CYTOSKELETON; HUMANS; HYPERGLYCEMIA; MYOSIN LIGHT CHAINS; PROTEIN KINASE C BETA; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 84889101377     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.151     Document Type: Article

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