Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 873-881

  Löbmann, Korbinian ^a,b   Grohganz, Holger ^b   Laitinen, Riikka ^c   Strachan, Clare ^a,d   Rades, Thomas ^a,b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Amino acids; Co amorphous; Dissolution; Drug; Glass transition temperature; Small molecular excipients; Stability

Indexed keywords

AMINO ACID MIXTURE; ARGININE; CARBAMAZEPINE; EXCIPIENT; INDOMETACIN; PHENYLALANINE; POLYMER; STABILIZING AGENT; TRYPTOPHAN; TYROSINE;

ARTICLE; BINDING SITE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; GLASS TRANSITION TEMPERATURE; MOLECULAR INTERACTION; MOLECULAR WEIGHT; SOLID STATE; X RAY POWDER DIFFRACTION;

AMINO ACIDS; CO-AMORPHOUS; DISSOLUTION; DRUG; GLASS TRANSITION TEMPERATURE; SMALL MOLECULAR EXCIPIENTS; STABILITY;

AMINO ACIDS; ARGININE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; PHENYLALANINE; POLYMERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TRYPTOPHAN; TYROSINE; X-RAY DIFFRACTION;

EID: 84889093957     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.03.014     Document Type: Article

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