Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 71, Issue 1, 2009, Pages 64-70

  Zhang, Fang ^a   Aaltonen, Jaakko ^a   Tian, Fang ^b   Saville, Dorothy J ^a   Rades, Thomas ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Amorphous; Particle size; Simvastatin; Solid state; Stability

Indexed keywords

SIMVASTATIN;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSE REFLECTANCE INFRARED FOURIER TRANSFORM SPECTROSCOPY; DIFFUSE REFLECTANCE SPECTROSCOPY; DRUG DEGRADATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; ENTHALPY; FOURIER TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; PARTICLE SIZE; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG STABILITY; PARTICLE SIZE; SIMVASTATIN; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; THERMODYNAMICS; X-RAY DIFFRACTION;

EID: 57349089295     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.07.010     Document Type: Article

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