High levels of heat shock protein 70 are associated with pro-inflammatory cytokines and may differentiate early- from late-onset preeclampsia

Journal of Reproductive Immunology

Volumn 100, Issue 2, 2013, Pages 129-134

  Peraçoli, Jose C ^a   Bannwart Castro, Camila F ^a   Romao, Mariana ^a   Weel, Ingrid C ^a   Ribeiro, Vanessa R ^a   Borges, Vera T M ^a   Rudge, Marilza V ^a   Witkin, Steven S ^b   Peraçoli, Maria T ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cytokines; Hsp60; Hsp70; IUGR; Preeclampsia

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHAPERONIN 60; CYTOKINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; LACTATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; UNCLASSIFIED DRUG; UREA; URIC ACID;

ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTRAUTERINE GROWTH RETARDATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEINURIA; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

CYTOKINES; HSP60; HSP70; IUGR; PREECLAMPSIA;

ADOLESCENT; ADULT; AGE OF ONSET; BLOOD PROTEINS; CHAPERONIN 60; CYTOKINES; FEMALE; FETAL GROWTH RETARDATION; GESTATIONAL AGE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; LIVER; PRE-ECLAMPSIA; PREGNANCY; YOUNG ADULT;

EID: 84889083026     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2013.08.003     Document Type: Article

References (42)

1. Asea A. Stress proteins and initiation of immune response: chaperokine activity of hsp72. Exerc. Immunol. Rev. 2005, 11:34-45.
2. Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., et al. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 2002, 277:15028-15034.
3. Austgulen R., Liabakk N.B., Brockhaus M., Espevik T. Soluble TNF receptors in amniotic fluid and in urine from pregnant women. J. Reprod. Immunol. 1992, 22:105-116.
4. Barut F., Barut A., Dogan Gun B., Kandemir N.O., Aktunc E., Harma M., et al. Expression of heat shock protein 70 and endothelial nitric oxide synthase in placental tissue of preeclamptic and intrauterine growth-restricted pregnancies. Pathol. Res. Pract. 2010, 206:651-656.
5. Battaglia F.C., Lubchenco L.O. A practical classification of newborn infants by weight and gestational age. J. Pediatr. 1967, 71:159-163.
6. Bausero M.A., Gastpar R., Multhoff G., Asea A. Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72. J. Immunol. 2005, 175:2900-2912.
7. Birnbaum G. Stress proteins: their role in the normal central nervous system and in disease states, especially multiple sclerosis. Springer Semin. Immunopathol. 1995, 17:107-118.
8. Borzychowski A.M., Sargent I.L., Redman C.W. Inflammation and pre-eclampsia. Semin. Fetal Neonatal Med. 2006, 11:309-316.
9. Chauhan S.P., Scardo J.A., Magann E.F., Devoe L.D., Hendrix N.W., Martin J.N. Detection of growth-restricted fetuses in preeclampsia: a case-control study. Obstet. Gynecol. 1999, 93:687-691.
10. Cristofalo R., Bannwart-Castro C.F., Magalhães C.G., Borges V.T., Peraçoli J.C., Witkin S.S., et al. Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women. Free Radic. Res. 2013, 47:268-275.
11. Giorgi V.S., Peraçoli M.T., Peraçoli J.C., Witkin S.S., Bannwart-Castro C.F. Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. J. Reprod. Immunol. 2012, 95:67-72.
12. Heimbach J.K., Reznikov L.L., Calkins C.M., Robinson T.N., Dinarello C.A., Harken A.H., et al. TNF receptor I is required for induction of macrophage heat shock protein 70. Am. J. Physiol. Cell Physiol. 2001, 281:C241-C247.
13. Hightower L.E. Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 1991, 66:191-197.
14. Hunter-Lavin C., Davies E.L., Bacelar M.M., Marshall M.J., Andrew S.M., Williams J.H. Hsp70 release from peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 2004, 324:511-517.
15. Inokuchi S., Aoyama T., Miura K., Osterreicher C.H., Kodama Y., Miyai K., et al. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:844-849.
16. Kalinderis M., Papanikolaou A., Kalinderi K., Ioannidou E., Giannoulis C., Karagiannis V., et al. Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia. Am. J. Reprod. Immunol. 2011, 66:468-475.
17. Kalinkovich A., Engelmann H., Harpaz N., Burstein R., Barak V., Kalickman I., et al. Elevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection. Clin. Exp. Immunol. 1992, 89:351-355.
18. Laskowska M., Laskowska K., Leszczyńska-Gorzelak B., Oleszczuk J. Maternal and umbilical sTNF-R1 in preeclamptic pregnancies with intrauterine normal and growth retarded fetus. Hypertens. Pregnancy 2007, 26:13-21.
19. Levy R. Genetic regulation of preimplantation embryo survival. Int. Rev. Cytol. 2001, 210:1-37.
20. Lok C.A., Jebbink J., Nieuwland R., Faas M.M., Boer K., Sturk A., et al. Leukocyte activation and circulating leukocyte-derived microparticles in preeclampsia. Am. J. Reprod. Immunol. 2009, 61:346-359.
21. Madách K., Molvarec A., Rigó J., Nagy B., Pénzes I., Karádi I., et al. Elevated serum 70kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008, 139:133-138.
22. Mestril R., Dillmann W.H. Heat shock proteins and protection against myocardial ischemia. J. Mol. Cell. Cardiol. 1995, 27:45-52.
23. Minowada G., Welch W. Variation in the expression and/or phosphorylation of the human low molecular weight stress protein during in vitro cell differentiation. J. Biol. Chem. 1995, 270:7047-7054.
24. Molvarec A., Prohászka Z., Nagy B., Szalay J., Füst G., Karádi I., et al. Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study. J. Hum. Hypertens. 2006, 20:780-786.
25. Molvarec A., Prohászka Z., Nagy B., Kalabay L., Szalay J., Füst G., et al. Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J. Reprod. Immunol. 2007, 73:172-179.
26. Molvarec A., Rigó J., Nagy B., Walentin S., Szalay J., Füst G., et al. Serum heat shock protein 70 levels are decreased in normal human pregnancy. J. Reprod. Immunol. 2007, 74:163-169.
27. Molvarec A., Derzsy Z., Kocsis J., Boze T., Nagy B., Balogh K., et al. Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia. Cell. Stress Chaperones 2009, 14:491-498.
28. Molvarec A., Rigó J., Lázár L., Balogh K., Makó V., Cervenak L., et al. Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia. Cell. Stress Chaperones 2009, 14:151-159.
29. Molvarec A., Tamási L., Losonczy G., Madách K., Prohászka Z., Rigó J. Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies. Cell. Stress Chaperones 2010, 15:237-247.
30. Molvarec A., Szarka A., Walentin S., Beko G., Karádi I., Prohászka Z., et al. Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia. Clin. Chim. Acta 2011, 412:1957-1962.
31. Padmini E., Lavanya S. HSP70-mediated control of endothelial cell apoptosis during pre-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011, 156:158-164.
32. Peraçoli J.C., Rudge M.V., Peraçoli M.T. Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia. Am. J. Reprod. Immunol. 2007, 57:177-185.
33. Peraçoli M.T., Bannwart C.F., Cristofalo R., Borges V.T.M., Costa R.A.A., Witkin S.S., et al. Increased reactive oxygen species and tumor necrosis factor-alpha production by monocytes are associated with elevated levels of uric acid in pre-eclamptic women. Am. J. Reprod. Immunol. 2011, 65:460-467.
34. Pockley A.G., Shepherd J., Corton J.M. Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals. Immunol. Invest. 1998, 27:367-377.
35. Pockley A.G., De Faire U., Kiessling R., Lemne C., Thulin T., Frostegård J. Circulating heat shock protein and heat shock protein antibody levels in established hypertension. J. Hypertens. 2002, 20:1815-1820.
36. Redman C.W., Sargent I.L. Latest advances in understanding preeclampsia. Science 2005, 308:1592-1594.
37. Report of the National High Blood Pressure Education Program (NHBPEP) working group on high blood pressure in pregnancy. Am. J. Obstet. Gynecol. 2000, 183:S1-S22.
38. Schipper E.J., Bolte A.C., Schalkwijk C.G., Van Geijn H.P., Dekker G.A. TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk women. J. Matern. Fetal Neonatal Med. 2005, 18:283-287.
39. Spinas G.A., Keller U., Brockhaus M. Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J. Clin. Invest. 1992, 90:533-536.
40. Szarka A., Rigó J., Lázár L., Beko G., Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol. 2010, 11:59.
41. Unal E.R., Robinson C.J., Johnson D.D., Chang E.Y. Second-trimester angiogenic factors as biomarkers for future-onset preeclampsia. Am. J. Obstet. Gynecol. 2007, 197:211.e1-211.e4.
42. Walker J.J. Pre-eclampsia. Lancet 2000, 356:1260-1265.