Scutellariae radix suppresses LPS-induced liver endothelial cell activation and inhibits hepatic stellate cell migration

Journal of Ethnopharmacology

Volumn 150, Issue 3, 2013, Pages 835-842

  Chen, Hong Jhang ^a   Liang, Tzu Ming ^b   Lee, I Jung ^a   Huang, Yi Tsau ^a,b   Lin, Yun Lian ^a,c  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Liver fibrosis; MCP 1; Rat hepatic stellate cell (rHSC); Rat liver endothelial cell (rLSEC); rLSEC conditioned medium; Scutellariae radix

Indexed keywords

ANTIFIBROTIC AGENT; BAICALEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SCUTELLARIAE RADIX; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; WOGONIN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; DRUG SCREENING; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER FIBROSIS; LIVER SINUSOIDAL ENDOTHELIAL CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; UPREGULATION;

RATTUS; SCUTELLARIA BAICALENSIS; SCUTELLARIA RADIX;

(MCP-1); (RHSCS); (RLSECS); (SAL B); (SBE); (TGF-Β1); (VEGF); (VEGFR); ETHANOLIC EXTRACTS OF SCUTELLARIAE RADIX; LIVER FIBROSIS; MCP-1; MONOCYTE CHEMOTACTIC PROTEIN 1; RAT HEPATIC STELLATE CELL (RHSC); RAT HEPATIC STELLATE CELLS; RAT LIVER ENDOTHELIAL CELL (RLSEC); RAT LIVER SINUSOIDAL ENDOTHELIAL CELLS; RLSEC CONDITIONED MEDIUM; SALVIANOLIC ACID B; SCUTELLARIAE RADIX; TRANSFORMING GROWTH FACTOR-BETA 1; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR;

ANIMALS; CELL MOVEMENT; CHEMOKINE CCL2; ENDOTHELIAL CELLS; FLAVONOIDS; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; LIPOPOLYSACCHARIDES; LIVER; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; SCUTELLARIA BAICALENSIS; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84889079573     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.08.049     Document Type: Article

References (44)

1. J.E. Adrian, K. Poelstra, G.L. Scherphof, D.K. Meijer, A.M. van Loenen-Weemaes, C. Reker-Smit, H.W. Morselt, P. Zwiers, and J.A. Kamps Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats Journal of Pharmacology and Experimental Therapeutics 321 2007 536 543 (Pubitemid 46624503)
2. A. Bishayee, A.S. Darvesh, T. Politis, and R. McGory Resveratrol and liver disease: from bench to bedside and community Liver International 30 2010 1103 1114
3. 4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation Laboratory Investigation 91 2011 1383 1395
4. F. Braet, and E. Wisse Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review Comparative Hepatology 1 2002 1
5. E. Chan, X.X. Liu, D.J. Guo, Y.W. Kwan, G.P. Leung, S.M. Lee, and S.W. Chan Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats The American Journal of Chinese Medicine 39 2011 693 704
6. C.F. Chien, Y.T. Wu, and T.H. Tsai Biological analysis of herbal medicines used for the treatment of liver diseases Biomedical Chromatography 25 2011 21 38
7. A. Dangi, T.L. Sumpter, S. Kimura, D.B. Stolz, N. Murase, G. Raimondi, Y. Vodovotz, C. Huang, A.W. Thomson, and C.R. Gandhi Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance Journal of Immunology 188 2012 3667 3677
8. S.M. Dauphinee, and A. Karsan Lipopolysaccharide signaling in endothelial cells Laboratory Investigation 86 2006 9 22 (Pubitemid 43250964)
9. L.D. Deleve, X. Wang, and Y. Guo Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence Hepatology 48 2008 920 930
10. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669 (Pubitemid 351615417)
11. S.L. Friedman, and F.J. Roll Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan Analytical Biochemistry 161 1987 207 218 (Pubitemid 17036709)
12. Q. Guo, L. Zhao, Q. You, Y. Yang, H. Gu, G. Song, N. Lu, and J. Xin Anti-hepatitis B virus activity of wogonin in vitro and in vivo Antiviral Research 74 2007 16 24 (Pubitemid 46366014)
13. V. Hernandez-Gea, and S.L. Friedman Pathogenesis of liver fibrosis Annual Review of Pathology 6 2011 425 456
14. K. Jagavelu, C. Routray, U. Shergill, S.P. O'Hara, W. Faubion, and V.H. Shah Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver Hepatology 52 2010 590 601
15. S.I. Jang, H.J. Kim, K.M. Hwang, S.J. Jekal, H.O. Pae, B.M. Choi, Y.G. Yun, T.O. Kwon, H.T. Chung, and Y.C. Kim Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice Immunopharmacology and Immunotoxicology 25 2003 585 594 (Pubitemid 37517858)
16. J.Y. Kim, S. Lee, D.H. Kim, B.R. Kim, R. Park, and B.M. Lee Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes Journal of Toxicology and Environmental Health A 65 2002 373 381 (Pubitemid 34264153)
17. S.J. Kim, and S.M. Lee Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition Toxicology and Applied Pharmacology 258 2012 43 50
18. T. Knittel, K. Neubauer, T. Armbrust, and G. Ramadori Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells Hepatology 21 1995 470 476
19. J.J. Kuo, C.Y. Wang, T.F. Lee, Y.T. Huang, and Y.L. Lin Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration Planta Medica 78 2012 341 348
20. TF Lee, YL Lin, and YT. Huang Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes Liver International 31 2011 618 629
21. J.S. Lee, D. Semela, J. Iredale, and V.H. Shah Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte? Hepatology 45 2007 817 825 (Pubitemid 46450633)
22. L. Leifeld, F.L. Dumoulin, I. Purr, K. Janberg, C. Trautwein, M. Wolff, M.P. Manns, T. Sauerbruch, and U. Spengler Early up-regulation of chemokine expression in fulminant hepatic failure Journal of Pathology 199 2003 335 344 (Pubitemid 36266856)
23. H.B. Li, Y. Jiang, and F. Chen Separation methods used for Scutellaria baicalensis active components Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 812 2004 277 290 (Pubitemid 39535417)
24. Y.L. Lin, C.H. Wu, Y.J. Huang, M.H. Luo, C.N. Wang, M.S. Shiao, and Y.T. Huang In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells Journal of Ethnopharmacology 105 2006 215 222
25. A.B. Lumsden, J.M. Henderson, and M.H. Kutner Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis Hepatology 8 1988 232 236
26. M. Maddaluno, G. Grassia, M.V. Di Lauro, A. Parisi, F. Maione, C. Cicala, D. De Filippis, T. Iuvone, A. Guglielmotti, P. Maffia, N. Mascolo, and A. Ialenti Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching PLoS One 7 2012 e47464
27. F. Marra, R.G. Romanelli, C. Giannini, P. Failli, S. Pastacaldi, M.C. Arrighi, M. Pinzani, G. Laffi, P. Montalto, and P. Gentilini Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells Hepatology 29 1999 140 148 (Pubitemid 29023996)
28. J.X. Nan, E.J. Park, Y.C. Kim, G. Ko, and D.H. Sohn Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats Journal of Pharmacy and Pharmacology 54 2002 555 563 (Pubitemid 34308500)
29. Y.H. Paik, R.F. Schwabe, R. Bataller, M.P. Russo, C. Jobin, and D.A. Brenner Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells Hepatology 37 2003 1043 1055 (Pubitemid 36538681)
30. T.L. Pan, P.W. Wang, Y.L. Leu, T.H. Wu, and T.S. Wu Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway Journal of Ethnopharmacology 139 2012 829 837
31. L.G. Rodriguez, X. Wu, and J.L. Guan Wound-healing assay Methods in Molecular Biology 294 2005 23 29
32. I. Sakaida, K. Hironaka, T. Kimura, S. Terai, T. Yamasaki, and K. Okita Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell Life Science 74 2004 2251 2263 (Pubitemid 38249546)
33. Y. Saiman, and S.L. Friedman The role of chemokines in acute liver injury Frontiers in Physiology 3 2012 213
34. E. Seki, S. de Minicis, S. Inokuchi, K. Taura, K. Miyai, N. van Rooijen, R.F. Schwabe, and D.A. Brenner CCR2 promotes hepatic fibrosis in mice Hepatology 50 2009 185 197
35. E. Seki, and B. Schnabl Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut Journal of Physiology 590 2012 447 458
36. I. Shimizu, Y.R. Ma, Y. Mizobuchi, F. Liu, T. Miura, Y. Nakai, M. Yasuda, M. Shiba, T. Horie, S. Amagaya, N. Kawada, H. Hori, and S. Ito Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats Hepatology 29 1999 149 160 (Pubitemid 29023997)
37. 4 liver fibrosis model in rats European Journal of Pharmacology 631 2010 53 60
38. M.K. Tsai, Y.L. Lin, and Y.T. Huang Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats Toxicology and Applied Pharmacology 242 2010 155 164
39. A. Uhrig, R. Banafsche, M. Kremer, S. Hegenbarth, A. Hamann, M. Neurath, G. Gerken, A. Limmer, and P.A. Knolle Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver Journal of Leukocyte Biology 77 2005 626 633 (Pubitemid 40628742)
40. M.D. Yang, Y.M. Chiang, R. Higashiyama, K. Asahina, D.A. Mann, J. Mann, C.C. Wang, and H. Tsukamoto Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor gamma in hepatic stellate cells for their antifibrotic effect Hepatology 55 2012 1271 1281
41. Y. Yang, S. Yang, M. Chen, X. Zhang, and Y. Zou Compound Astragalus and Salvia miltiorrhiza Extract exerts anti-fibrosis by mediating TGF-beta/Smad signaling in myofibroblasts Journal of Ethnopharmacology 118 2008 264 270
42. 2 induced liver injury European Journal of Pharmacology 536 2006 192 199
43. M.C. Zhen, X.H. Huang, Q. Wang, K. Sun, Y.J. Liu, W. Li, L.J. Zhang, L.Q. Cao, and X.L. Chen Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation Acta Pharmacologica Sinica 27 2006 1600 1607 (Pubitemid 44813898)
44. C.D. Zois, G.H. Baltayiannis, P. Karayiannis, and E.V. Tsianos Systematic review: hepatic fibrosis - regression with therapy Alimentary Pharmacology & Therapeutics 28 2008 1175 1187