Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration

Planta Medica

Volumn 78, Issue 4, 2012, Pages 341-348

  Kuo, Jong Jen ^a,b   Wang, Chih Yang ^a   Lee, Ting Fang ^a   Huang, Yi Tsau ^a,c   Lin, Yun Lian ^c,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

1,2,3,4,6 penta O galloyl D glucose; chemotaxis; hepatic stellate cells; Paeonia lactiflora; paeonol; PDGF BB; Ranunculaceae

Indexed keywords

1,2,3,4,6 PENTA O GALLOYL BETA DEXTRO GLUCOSE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PAEONIA RADIX; PEONOL; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PAEONIA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STELLATE CELL; WOUND HEALING;

ACETOPHENONES; ACTINS; ANIMALS; CELL LINE; CELL MOVEMENT; CELL TRANSDIFFERENTIATION; CHEMOTAXIS; COLLAGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATIC STELLATE CELLS; HUMANS; HYDROLYZABLE TANNINS; MALE; PAEONIA; PLANT EXTRACTS; PLANT ROOTS; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY;

PAEONIA LACTIFLORA; RANUNCULACEAE; RATTUS;

EID: 84862798831     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280472     Document Type: Article

References (36)

1. Senoo H, Yoshikawa K, Mori M, Miura M, Imai K, Mezaki Y. Hepatic stellate cell (Vitamin A-storing cell) and its relative - past, present and future. Cell Biol Int 2010; 34: 1247-1272
2. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-1669 (Pubitemid 351615417)
3. Wong L, Yamasaki G, Johnson RJ, Friedman SL. Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 1994; 94: 1563-1569
4. Pinzani M, Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001; 21: 397-416 (Pubitemid 32923768)
5. Ikeda K,Wakahara T,Wang YQ, Kadoya H, Kawada N, Kaneda K. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 1999; 29: 1760-1767 (Pubitemid 29247050)
6. Melton AC, Yee HF. Hepatic stellate cell protusions couple platelet-derived growth factor-BB to chemotaxis. Hepatology 2007; 45: 1446-1453 (Pubitemid 46918328)
7. Friedman SL. Closing in on the signals of hepatic fibrosis. Gastroenterology 1997; 112: 1406-1414
8. Imanishi Y, Maeda N, Otogawa K, Seki S, Matsui H, Kawada N, Arakawa T. Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J Hepatol 2004; 41: 242-250 (Pubitemid 39177628)
9. Lin YL, Wu CF, Huang YT. Phenols from the roots of Rheum palmatum attenuates chemotaxis in rat hepatic stellate cells. Planta Med 2008; 74: 1246-1252
10. Xiao P, Li DP, Yang SL. Modern Chinese materia medica, Volume 1. Beijing: Chemical Industry Press; 2002: 493-500
11. Wang HB, Gu WF, Chu WJ, Zhang S, Tang XC, Qin GW. Monoterpene glucosides from Paeonia lactiflora. J Nat Prod 2009; 72: 1321-1324
12. Braca A, Kiem PV, Yen PH, Nhiem NX, Quang TH, Cuong NX, Minh CV. New monoterpene glycosides from Paeonia lactiflora. Fitoterapia 2008; 79: 117-120
13. Lin HC, Ding HY, Ko FN, Teng CM,Wu YC. Aggregation inhibitory activity of minor acetophenones from Paeonia species. Planta Med 1999; 65: 595-599
14. Kamiya K, Yoshioka K, Saiki Y, Ikuta A, Satake T. Triterpenoids and flavonoids from Paeonia lactiflora. Phytochemistry 1997; 44: 141-144 (Pubitemid 27091446)
15. Nishizawa M, Yamagishi T, Nonaka GI, Nishioka I, Nagasawa T, Oura H. Tannins and related compounds XII. Isolation and characterization of galloylglucoses from Paeoniae Radix and their effect on urea-nitrogen concentration in rat serum. Chem Pharm Bull 1983; 30: 2593-2600
16. Baumgartner RR, Steinmann D, Heiss EH, Atanasov AG, Ganzera M, Stuppner H, Dirsch VM. Bioactivity-guided isolation of 1,2,3,4,6-penta-O-galloyl-D-gluco- pyrannose from Paeonia lactiflora roots as a PTP1B inhibitor. J Nat Prod 2010; 73: 1578-1581
17. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004; 92: 1-21 (Pubitemid 38510258)
18. Hsu FL, Lai CW, Cheng JT. Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med 1997; 63: 323-325
19. Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM. Paeoniae radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci 2002; 71: 2267-2277 (Pubitemid 35246215)
20. Lin HC, Ding HY, Ko FN, Teng CM,Wu YC. Aggregation inhibitory activity of minor acetophenones from Paeonia species. Planta Med 1999; 65: 595-599
21. Xiao L,Wang YZ, Liu J, Luo XT, Ye Y, Zhu XZ. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Life Sci 2005; 78: 413-420
22. Kim HJ, Chang EJ, Cho SH, Chung SK, Park HD, Choi SW. Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora. Biosci Biotechnol Biochem 2002; 66: 1990-1993 (Pubitemid 39246814)
23. Lee TF, Lin YL, Huang YT. Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes. Liver Int 2011; 31: 618-629
24. Friedman SL, Roll FJ. Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan. Anal Biochem 1987; 161: 207-218 (Pubitemid 17036709)
25. Lin YL, Wu CH, Huang YC, Luo MH, Wang CN, Shiao MS, Huang YT. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells. J Ethnopharmacol 2006; 105: 215-222
26. Lin YL, Wu CF, Huang YT. Effects of rhubarb on migration of rat hepatic stellate cells. J Gastroenterol Hepatol 2009; 24: 453-461
27. Lee TF, Lin YL, Huang YT. Studies on anti-proliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta Med 2007; 73: 527-534
28. Tsai MK, Lin YL, Huang YT. Effects of salvianolic acids, A and B on oxidative stress and hepatic fibrosis in rats. Toxicol Appl Pharmacol 2010; 242: 155-164
29. Lau CH, Chan CM, Chan YW, Lau KM, Lau TW, Lam FC, Law WT, Che CT, Leung PC, Fung KP, Ho YY, Lau CBS. Pharmacological investigations ofthe anti-diabetic effect of Cortex Moutan and its active component paeonol. Phytomedicine 2007; 14: 778-784 (Pubitemid 47554505)
30. Li Y, Kim J, Li J, Liu F, Liu X, Himmeldirk K, Ren Y,Wagner TE, Chen X. Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway. Biochem Biophys Res Commun 2005; 336: 430-437 (Pubitemid 41267248)
31. Kinnman N, Hultcrantz R, Barbu V, Rey C,Wendum D, Poupon R, Housset C. PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury. Lab Invest 2000; 80: 697-707 (Pubitemid 30340654)
32. Ballardini G, Esposti SD, Bianchi FB, Degiorgi LB, Faccani A, Biolchini L, Busachi CA, Pisi E. Correlation between Ito cell and fibrogenesis in an experimental model of hepatic fibrosis. A sequential sterological study. Liver 1983; 3: 58-63 (Pubitemid 13124586)
33. Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY. The inhibitory effects of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression. Exp Cell Res 2010; 317: 1083-1092
34. Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci 2004; 117: 4619-4628 (Pubitemid 39433429)
35. Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K. JNK phosphorylation paxillin and regulates cell migration. Nature 2003; 424: 219-223 (Pubitemid 36858692)
36. Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol Mech Dis 2011; 6: 425-456