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Volumn 10, Issue 1, 2014, Pages 17-31

Hyaluronic acid-based conjugates for tumor-targeted drug delivery and imaging

Author keywords

Conjugate; Drug delivery; Hyaluronic acid; Imaging agent

Indexed keywords

ACTIVATED MACROPHAGES; BIOLOGICAL PROPERTIES; CONJUGATE; DRUG DELIVERY SYSTEM; IMAGING AGENT; RECEPTOR-MEDIATED ENDOCYTOSIS; TUMOR-TARGETED DRUG DELIVERIES; WATER SOLUBILITIES;

EID: 84889051137     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1761     Document Type: Review
Times cited : (47)

References (75)
  • 2
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • R. Duncan, The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2, 347 (2003).
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 347
    • Duncan, R.1
  • 3
    • 0016622773 scopus 로고
    • Structure and properties of pharmacologically active polymers
    • H. Ringsdorf, Structure and properties of pharmacologically active polymers. Journal of Polymer Science: Polymer Symposia 51, 135 (1975).
    • (1975) Journal of Polymer Science: Polymer Symposia , vol.51 , pp. 135
    • Ringsdorf, H.1
  • 4
    • 0000104561 scopus 로고    scopus 로고
    • Hyaluronan: Preparation, structure, properties, and applications
    • L. Lapcčik, S. De Smedt, J. Demeester, and P. Chabrecček, Hyaluronan: Preparation, structure, properties, and applications. Chem. Rev. 98, 2663 (1998).
    • (1998) Chem. Rev. , vol.98 , pp. 2663
    • Lapcčik, L.1    De Smedt, S.2    Demeester, J.3    Chabrecček, P.4
  • 5
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: From extracellular glue to pericellular cue
    • B. P. Toole, Hyaluronan: From extracellular glue to pericellular cue. Nat. Rev. Cancer 4, 528 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 528
    • Toole, B.P.1
  • 8
    • 51049098968 scopus 로고    scopus 로고
    • Anticancer therapeutics: Targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor
    • V. M. Platt and F. C. Szoka, Anticancer therapeutics: Targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol. Pharm. 5, 474 (2008).
    • (2008) Mol. Pharm. , vol.5 , pp. 474
    • Platt, V.M.1    Szoka, F.C.2
  • 9
    • 84863866947 scopus 로고    scopus 로고
    • Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer
    • K. Y. Choi, G. Saravanakumar, J. H. Park, and K. Park, Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer. Colloids and Surfaces B: Biointerfaces 99, 82 (2012).
    • (2012) Colloids and Surfaces B: Biointerfaces , vol.99 , pp. 82
    • Choi, K.Y.1    Saravanakumar, G.2    Park, J.H.3    Park, K.4
  • 10
    • 79955673207 scopus 로고    scopus 로고
    • Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications
    • C. E. Schanté, G. Zuber, C. Herlin, and T. F. Vandamme, Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohydr. Polym. 85, 469 (2011).
    • (2011) Carbohydr. Polym. , vol.85 , pp. 469
    • Schanté, C.E.1    Zuber, G.2    Herlin, C.3    Vandamme, T.F.4
  • 11
  • 12
    • 0032819928 scopus 로고    scopus 로고
    • New strategy for chemical modification of hyaluronic acid: Preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels
    • P. Bulpitt and D. Aeschlimann, New strategy for chemical modification of hyaluronic acid: Preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels. J. Biomed. Mater. Res. 47, 152 (1999).
    • (1999) J. Biomed. Mater. Res. , vol.47 , pp. 152
    • Bulpitt, P.1    Aeschlimann, D.2
  • 13
    • 67249100358 scopus 로고    scopus 로고
    • Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis
    • G. Jiang, K. Park, J. Kim, K. S. Kim, and S. K. Hahn, Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis. Mol. Pharm. 6, 727 (2009).
    • (2009) Mol. Pharm. , vol.6 , pp. 727
    • Jiang, G.1    Park, K.2    Kim, J.3    Kim, K.S.4    Hahn, S.K.5
  • 14
    • 0033200301 scopus 로고    scopus 로고
    • Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate
    • Y. Luo and G. D. Prestwich, Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug. Chem. 10, 755 (1999).
    • (1999) Bioconjug. Chem. , vol.10 , pp. 755
    • Luo, Y.1    Prestwich, G.D.2
  • 17
    • 45749088187 scopus 로고    scopus 로고
    • Hyaluronic acid-paclitaxel conjugate micelles: Synthesis, characterization, and antitumor activity
    • H. Lee, K. Lee, and T. G. Park, Hyaluronic acid-paclitaxel conjugate micelles: Synthesis, characterization, and antitumor activity. Bioconjug. Chem. 19, 1319 (2008).
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1319
    • Lee, H.1    Lee, K.2    Park, T.G.3
  • 18
    • 0034208501 scopus 로고    scopus 로고
    • A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells
    • Y. Luo, M. R. Ziebell, and G. D. Prestwich, A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 1, 208 (2000).
    • (2000) Biomacromolecules , vol.1 , pp. 208
    • Luo, Y.1    Ziebell, M.R.2    Prestwich, G.D.3
  • 19
    • 13644257605 scopus 로고    scopus 로고
    • Delivery platform for hydrophobic drugs: Prodrug approach combined with self-assembled multilayers
    • B. Thierry, P. Kujawa, C. Tkaczyk, F. M. Winnik, L. Bilodeau, and M. Tabrizian, Delivery platform for hydrophobic drugs: Prodrug approach combined with self-assembled multilayers. J. Am. Chem. Soc. 127, 1626 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 1626
    • Thierry, B.1    Kujawa, P.2    Tkaczyk, C.3    Winnik, F.M.4    Bilodeau, L.5    Tabrizian, M.6
  • 23
    • 84862665043 scopus 로고    scopus 로고
    • Hyaluronan oligomers-hpma copolymer conjugates for targeting paclitaxel to CD44-overexpressing ovarian carcinoma
    • G. Journo-Gershfeld, D. Kapp, Y. Shamay, J. Kopeéek, and A. David, Hyaluronan oligomers-hpma copolymer conjugates for targeting paclitaxel to CD44-overexpressing ovarian carcinoma. Pharm. Res. 29, 1121 (2012).
    • (2012) Pharm. Res. , vol.29 , pp. 1121
    • Journo-Gershfeld, G.1    Kapp, D.2    Shamay, Y.3    Kopeéek, J.4    David, A.5
  • 24
    • 0036115512 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin by hpma copolymer-hyaluronan bioconjugates
    • Y. Luo, N. J. Bernshaw, Z.-R. Lu, J. Kopecek, and G. D. Prestwich, Targeted delivery of doxorubicin by hpma copolymer-hyaluronan bioconjugates. Pharm. Res. 19, 396 (2002).
    • (2002) Pharm. Res. , vol.19 , pp. 396
    • Luo, Y.1    Bernshaw, N.J.2    Lu, Z.-R.3    Kopecek, J.4    Prestwich, G.D.5
  • 25
    • 0035985787 scopus 로고    scopus 로고
    • Molecular action of methotrexate in inflammatory diseases
    • E. S. Chan and B. N. Cronstein, Molecular action of methotrexate in inflammatory diseases. Arthritis Research 4, 266 (2002).
    • (2002) Arthritis Research , vol.4 , pp. 266
    • Chan, E.S.1    Cronstein, B.N.2
  • 26
    • 67649764421 scopus 로고    scopus 로고
    • Methotrexate loaded self stabilized calcium phosphate nanoparticles: A novel inorganic carrier for intracellular drug delivery
    • U. Mukesh, V. Kulkarni, R. Tushar, and R. S. Murthy, Methotrexate loaded self stabilized calcium phosphate nanoparticles: A novel inorganic carrier for intracellular drug delivery. J. Biomed. Nanotechnol. 5, 99 (2009).
    • (2009) J. Biomed. Nanotechnol. , vol.5 , pp. 99
    • Mukesh, U.1    Kulkarni, V.2    Tushar, R.3    Murthy, R.S.4
  • 27
    • 84856082845 scopus 로고    scopus 로고
    • Methotrexate: A detailed review on drug delivery and clinical aspects
    • Z. A. Khan, R. Tripathi, and B. Mishra, Methotrexate: A detailed review on drug delivery and clinical aspects. Expert Opinion on Drug Delivery 9, 151 (2012).
    • (2012) Expert Opinion on Drug Delivery , vol.9 , pp. 151
    • Khan, Z.A.1    Tripathi, R.2    Mishra, B.3
  • 30
    • 79955476046 scopus 로고    scopus 로고
    • Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability
    • S. Manju and K. Sreenivasan, Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability. J. Colloid Interface Sci. 359, 318 (2011).
    • (2011) J. Colloid Interface Sci. , vol.359 , pp. 318
    • Manju, S.1    Sreenivasan, K.2
  • 31
    • 0032937370 scopus 로고    scopus 로고
    • Hyaluronic acid as drug delivery for sodium butyrate: Improvement of the anti-proliferative activity on a breast-cancer cell line
    • D. Coradini, C. Pellizzaro, G. Miglierini, M. G. Daidone, and A. Perbellini, Hyaluronic acid as drug delivery for sodium butyrate: Improvement of the anti-proliferative activity on a breast-cancer cell line. Int. J. Cancer 81, 411 (1999).
    • (1999) Int. J. Cancer , vol.81 , pp. 411
    • Coradini, D.1    Pellizzaro, C.2    Miglierini, G.3    Daidone, M.G.4    Perbellini, A.5
  • 32
    • 81855171176 scopus 로고    scopus 로고
    • Hyaluronan: A suitable carrier for an histone deacetylase inhibitor in the treatment of human solid tumors
    • D. Coradini and A. Perbellini, Hyaluronan: A suitable carrier for an histone deacetylase inhibitor in the treatment of human solid tumors. Cancer Therapy 2, 201 (2004).
    • (2004) Cancer Therapy , vol.2 , pp. 201
    • Coradini, D.1    Perbellini, A.2
  • 35
    • 70349978292 scopus 로고    scopus 로고
    • Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines
    • F. Greco and M. J. Vicent, Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. Adv. Drug Deliv. Rev. 61, 1203 (2009).
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1203
    • Greco, F.1    Vicent, M.J.2
  • 36
    • 19544386612 scopus 로고    scopus 로고
    • In vivo imaging of retinoic acid receptor β2 transcriptional activation by the histone deacetylase inhibitor ms-275 in retinoid-resistant prostate cancer cells
    • D. Z. Qian, M. Ren, Y. Wei, X. Wang, F. van de Geijn, C. Rasmussen, O. Nakanishi, N. Sacchi, and R. Pili, In vivo imaging of retinoic acid receptor β2 transcriptional activation by the histone deacetylase inhibitor ms-275 in retinoid-resistant prostate cancer cells. The Prostate 64, 20 (2005).
    • (2005) The Prostate , vol.64 , pp. 20
    • Qian, D.Z.1    Ren, M.2    Wei, Y.3    Wang, X.4    Van De Geijn, F.5    Rasmussen, C.6    Nakanishi, O.7    Sacchi, N.8    Pili, R.9
  • 38
    • 3142615372 scopus 로고    scopus 로고
    • The RNAi revolution
    • C. D. Novina and P. A. Sharp, The RNAi revolution. Nature 430, 161 (2004).
    • (2004) Nature , vol.430 , pp. 161
    • Novina, C.D.1    Sharp, P.A.2
  • 39
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • G. J. Hannon and J. J. Rossi, Unlocking the potential of the human genome with RNA interference. Nature 431, 371 (2004).
    • (2004) Nature , vol.431 , pp. 371
    • Hannon, G.J.1    Rossi, J.J.2
  • 41
    • 0034019945 scopus 로고    scopus 로고
    • Cationic polymer based gene delivery systems
    • S. De Smedt, J. Demeester, and W. Hennink, Cationic polymer based gene delivery systems. Pharm. Res. 17, 113 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 113
    • De Smedt, S.1    Demeester, J.2    Hennink, W.3
  • 42
    • 2942632966 scopus 로고    scopus 로고
    • PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
    • S. Mishra, P. Webster, and M. E. Davis, PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 83, 97 (2004).
    • (2004) Eur. J. Cell Biol. , vol.83 , pp. 97
    • Mishra, S.1    Webster, P.2    Davis, M.E.3
  • 43
    • 38349136435 scopus 로고    scopus 로고
    • Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells
    • M. Hornof, M. de la Fuente, M. Hallikainen, R. H. Tammi, and A. Urtti, Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells. The Journal of Gene Medicine 10, 70 (2008).
    • (2008) The Journal of Gene Medicine , vol.10 , pp. 70
    • Hornof, M.1    De La Fuente, M.2    Hallikainen, M.3    Tammi, R.H.4    Urtti, A.5
  • 44
    • 70449091495 scopus 로고    scopus 로고
    • Positive hyaluronan/PEI/DNA complexes as a target-specific intracellular delivery to malignant breast cancer
    • X. Sun, P. Ma, X. Cao, L. Ning, Y. Tian, and C. Ren, Positive hyaluronan/PEI/DNA complexes as a target-specific intracellular delivery to malignant breast cancer. Drug Deliv. 16, 357 (2009).
    • (2009) Drug Deliv. , vol.16 , pp. 357
    • Sun, X.1    Ma, P.2    Cao, X.3    Ning, L.4    Tian, Y.5    Ren, C.6
  • 45
    • 0032125910 scopus 로고    scopus 로고
    • Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(l-lysine) backbone and hyaluronic acid side chains for a DNA carrier
    • S. Asayama, M. Nogawa, Y. Takei, T. Akaike, and A. Maruyama, Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(l-lysine) backbone and hyaluronic acid side chains for a DNA carrier. Bioconjug. Chem. 9, 476 (1998).
    • (1998) Bioconjug. Chem. , vol.9 , pp. 476
    • Asayama, S.1    Nogawa, M.2    Takei, Y.3    Akaike, T.4    Maruyama, A.5
  • 47
    • 41949107664 scopus 로고    scopus 로고
    • Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells
    • A. Saraf, M. C. Hacker, B. Sitharaman, K. J. Grande-Allen, M. A. Barry, and A. G. Mikos, Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules 9, 818 (2008).
    • (2008) Biomacromolecules , vol.9 , pp. 818
    • Saraf, A.1    Hacker, M.C.2    Sitharaman, B.3    Grande-Allen, K.J.4    Barry, M.A.5    Mikos, A.G.6
  • 48
    • 77957935984 scopus 로고    scopus 로고
    • Amphoteric hyaluronic acid derivative for targeting gene delivery
    • J. Yao, Y. Fan, R. Du, J. Zhou, Y. Lu, W. Wang, J. Ren, and X. Sun, Amphoteric hyaluronic acid derivative for targeting gene delivery. Biomaterials 31, 9357 (2010).
    • (2010) Biomaterials , vol.31 , pp. 9357
    • Yao, J.1    Fan, Y.2    Du, R.3    Zhou, J.4    Lu, Y.5    Wang, W.6    Ren, J.7    Sun, X.8
  • 49
    • 84862655669 scopus 로고    scopus 로고
    • Mannosylated polyethyleneimine-hyaluronan nanohybrids for targeted gene delivery to macrophage-like cell lines
    • S. Mahor, B. C. Dash, S. O'Connor, and A. Pandit, Mannosylated polyethyleneimine-hyaluronan nanohybrids for targeted gene delivery to macrophage-like cell lines. Bioconjug. Chem. 23, 1138 (2012).
    • (2012) Bioconjug. Chem. , vol.23 , pp. 1138
    • Mahor, S.1    Dash, B.C.2    O'Connor, S.3    Pandit, A.4
  • 50
    • 33646690293 scopus 로고    scopus 로고
    • Hyaluronic acid and its derivative as a multi-functional gene expression enhancer: Protection from non-specific interactions, adhesion to targeted cells, and transcriptional activation
    • T. Ito, N. Iida-Tanaka, T. Niidome, T. Kawano, K. Kubo, K. Yoshikawa, T. Sato, Z. Yang, and Y. Koyama, Hyaluronic acid and its derivative as a multi-functional gene expression enhancer: Protection from non-specific interactions, adhesion to targeted cells, and transcriptional activation. J. Control Release 112, 382 (2006).
    • (2006) J. Control Release , vol.112 , pp. 382
    • Ito, T.1    Iida-Tanaka, N.2    Niidome, T.3    Kawano, T.4    Kubo, K.5    Yoshikawa, K.6    Sato, T.7    Yang, Z.8    Koyama, Y.9
  • 52
    • 84866548075 scopus 로고    scopus 로고
    • Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex
    • M. Han, Q. Lv, X.-J. Tang, Y.-L. Hu, D.-H. Xu, F.-Z. Li, W.-Q. Liang, and J.-Q. Gao, Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex. J. Control Release 163, 136 (2012).
    • (2012) J. Control Release , vol.163 , pp. 136
    • Han, M.1    Lv, Q.2    Tang, X.-J.3    Hu, Y.-L.4    Xu, D.-H.5    Li, F.-Z.6    Liang, W.-Q.7    Gao, J.-Q.8
  • 53
    • 79958176375 scopus 로고    scopus 로고
    • Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
    • R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, and Z. Zhong, Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Control Release 152, 2 (2011).
    • (2011) J. Control Release , vol.152 , pp. 2
    • Cheng, R.1    Feng, F.2    Meng, F.3    Deng, C.4    Feijen, J.5    Zhong, Z.6
  • 54
    • 34648817050 scopus 로고    scopus 로고
    • Antisense oligodeoxynucleotide-conjugated hyaluronic acid/protamine nanocomplexes for intracellular gene inhibition
    • H. Mok, J. W. Park, and T. G. Park, Antisense oligodeoxynucleotide- conjugated hyaluronic acid/protamine nanocomplexes for intracellular gene inhibition. Bioconjug. Chem. 18, 1483 (2007).
    • (2007) Bioconjug. Chem. , vol.18 , pp. 1483
    • Mok, H.1    Park, J.W.2    Park, T.G.3
  • 56
    • 67149136446 scopus 로고    scopus 로고
    • Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: Synthesis, characterization, and in vivo biodistribution
    • K. Y. Choi, K. H. Min, J. H. Na, K. Choi, K. Kim, J. H. Park, I. C. Kwon, and S. Y. Jeong, Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: Synthesis, characterization, and in vivo biodistribution. J. Mater. Chem. 19, 4102 (2009).
    • (2009) J. Mater. Chem. , vol.19 , pp. 4102
    • Choi, K.Y.1    Min, K.H.2    Na, J.H.3    Choi, K.4    Kim, K.5    Park, J.H.6    Kwon, I.C.7    Jeong, S.Y.8
  • 57
    • 77953716727 scopus 로고    scopus 로고
    • Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel
    • G. Saravanakumar, K. Y. Choi, H. Y. Yoon, K. Kim, J. H. Park, I. C. Kwon, and K. Park, Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel. Int. J. Pharm. 394, 154 (2010).
    • (2010) Int. J. Pharm. , vol.394 , pp. 154
    • Saravanakumar, G.1    Choi, K.Y.2    Yoon, H.Y.3    Kim, K.4    Park, J.H.5    Kwon, I.C.6    Park, K.7
  • 58
    • 66849083442 scopus 로고    scopus 로고
    • Poly[lactic-co-(glycolic acid)]-grafted hyaluronic acid copolymer micelle nanoparticles for target-specific delivery of doxorubicin
    • H. Lee, C. H. Ahn, and T. G. Park, Poly[lactic-co-(glycolic acid)]-grafted hyaluronic acid copolymer micelle nanoparticles for target-specific delivery of doxorubicin. Macromol. Biosci. 9, 336 (2009).
    • (2009) Macromol. Biosci. , vol.9 , pp. 336
    • Lee, H.1    Ahn, C.H.2    Park, T.G.3
  • 59
    • 77951135224 scopus 로고    scopus 로고
    • Self-assembled amphiphilic hyaluronic acid graft copolymers for targeted release of antitumoral drug
    • G. Pitarresi, F. S. Palumbo, A. Albanese, C. Fiorica, P. Picone, and G. Giammona, Self-assembled amphiphilic hyaluronic acid graft copolymers for targeted release of antitumoral drug. J. Drug Target. 18, 264 (2010).
    • (2010) J. Drug Target. , vol.18 , pp. 264
    • Pitarresi, G.1    Palumbo, F.S.2    Albanese, A.3    Fiorica, C.4    Picone, P.5    Giammona, G.6
  • 60
    • 47649103158 scopus 로고    scopus 로고
    • Preparation and characterization of HA-PEG-PCL intelligent core-corona nanoparticles for delivery of doxorubicin
    • A. K. Yadav, P. Mishra, S. Jain, P. Mishra, A. K. Mishra, and G. P. Agrawal, Preparation and characterization of HA-PEG-PCL intelligent core-corona nanoparticles for delivery of doxorubicin. J. Drug Target. 16, 464 (2008).
    • (2008) J. Drug Target. , vol.16 , pp. 464
    • Yadav, A.K.1    Mishra, P.2    Jain, S.3    Mishra, P.4    Mishra, A.K.5    Agrawal, G.P.6
  • 63
    • 73649133678 scopus 로고    scopus 로고
    • Overcoming the barriers in micellar drug delivery: Loading efficiency. In vivo stability, and micelle-cell interaction
    • S. Kim, Y. Shi, J. Y. Kim, K. Park, and J.-X. Cheng, Overcoming the barriers in micellar drug delivery: Loading efficiency. in vivo stability, and micelle-cell interaction. Expert Opinion on Drug Delivery 7, 49 (2010).
    • (2010) Expert Opinion on Drug Delivery , vol.7 , pp. 49
    • Kim, S.1    Shi, Y.2    Kim, J.Y.3    Park, K.4    Cheng, J.-X.5
  • 73
    • 84855722431 scopus 로고    scopus 로고
    • Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
    • J. Li, M. Huo, J. Wang, J. Zhou, J. M. Mohammad, Y. Zhang, Q. Zhu, A. Y. Waddad, and Q. Zhang, Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel. Biomaterials 33, 2310 (2012).
    • (2012) Biomaterials , vol.33 , pp. 2310
    • Li, J.1    Huo, M.2    Wang, J.3    Zhou, J.4    Mohammad, J.M.5    Zhang, Y.6    Zhu, Q.7    Waddad, A.Y.8    Zhang, Q.9
  • 75
    • 84870937162 scopus 로고    scopus 로고
    • Hyaluronated fullerenes with photoluminescent and antitumoral activity
    • D. S. Kwag, K. Park, K. T. Oh, and E. S. Lee, Hyaluronated fullerenes with photoluminescent and antitumoral activity. Chem. Commun. 49, 282 (2013).
    • (2013) Chem. Commun. , vol.49 , pp. 282
    • Kwag, D.S.1    Park, K.2    Oh, K.T.3    Lee, E.S.4


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