The effect of Ginkgo biloba on functional outcome of patients with acute ischemic stroke: A double-blind, placebo-controlled, randomized clinical trial

Journal of Stroke and Cerebrovascular Diseases

Volumn 22, Issue 8, 2013, Pages

  Oskouei, Darioush Savadi ^a   Rikhtegar, Reza ^a,b,d   Hashemilar, Mazyar ^a   Sadeghi Bazargani, Homayoun ^a   Sharifi Bonab, Mohsen ^a   Sadeghi Hokmabadi, Elyar ^a   Zarrintan, Sina ^a,c   Sharifipour, Ehsan ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute ischemic stroke; cerebrovascular; Gingko biloba; randomized controlled trial; thrombotic

Indexed keywords

GINKGO BILOBA EXTRACT; PLACEBO; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROPROTECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TABLET; TREATMENT OUTCOME; AGED; CONVALESCENCE; DISABILITY; GINKGO BILOBA; IRAN; MEDICINAL PLANT; MIDDLE AGED; PATHOPHYSIOLOGY; PHYTOTHERAPY; SEVERITY OF ILLNESS INDEX; STROKE; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; DISABILITY EVALUATION; DOUBLE-BLIND METHOD; FEMALE; GINKGO BILOBA; HUMANS; IRAN; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84889038630     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2013.06.010     Document Type: Article

References (45)

1. A.S. Bavil, K. Ghabili, and S.E. Daneshmand Prevalence of significant carotid artery stenosis in Iranian patients with peripheral arterial disease Vasc Health Risk Manag 7 2011 629 632
2. M. Farhoudi, K. Mehrvar, and N. Aslanabadi Doppler study of cerebral arteries in hypercholesterolemia Vasc Health Risk Manag 7 2011 203 207
3. J. Biller, B.B. Love, and M.J. Schneck Vascular diseases of the nervous system: Ischemic cerebrovascular disease R.B. Daroff, G.M. Fenichel, J. Jankovic, Bradley's neurology in clinical practice 6th ed. Principles of diagnosis and management Vol II 2012 Elsevier Saunders Philadelphia 1003 1047
4. J.D. Burns, D.M. Green, and K. Metivier Intensive care management of acute ischemic stroke Emerg Med Clin North Am 30 2012 713 744
5. D. Devos, M. Sevin, and S. De Gaalon Management of ischemic stroke in the hyperacute phase Panminerva Med 55 2013 59 78
6. R.H. Llinas Ischemic stroke and ICU care Semin Neurol 28 2008 645 656
7. R. Kollmar, and S. Schwab Ischaemic stroke: Acute management, intensive care, and future perspectives Br J Anaesth 99 2007 95 101
8. A. Abou-Chebl Management of acute ischemic stroke Curr Cardiol Rep 15 2013 348
9. W.L. Baker, J.C. Marrs, and L.E. Davis Key articles and guidelines in the acute management and secondary prevention of ischemic stroke Pharmacotherapy 33 2013 e115 e142
10. E.C. Jauch, J.L. Saver, and H.P. Adams Jr. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association Stroke 44 2013 870 947
11. H. Milionis, and P. Michel Acute ischemic cerebrovascular events on antiplatelet therapy: What is the optimal prevention strategy? Curr Pharm Des 19 2013 3788 3794
12. R. Rodrigo, R. Fernández-Gajardo, and R. Gutiérrez Oxidative stress and pathophysiology of ischemic stroke: Novel therapeutic opportunities CNS Neurol Disord Drug Targets 2013 [Epub ahead of print]
13. A. Tuttolomondo, R. Di Sciacca, and D. Di Raimondo Neuron protection as a therapeutic target in acute ischemic stroke Curr Top Med Chem 9 2009 1317 1334
14. M.D. Ginsberg Neuroprotection for ischemic stroke: Past, present and future Neuropharmacology 55 2008 363 389
15. B. Ovbiagele, C.S. Kidwell, and S. Starkman Neuroprotective agents for the treatment of acute ischemic stroke Curr Neurol Neurosci Rep 3 2003 9 20
16. J.V. Smith, and Y. Luo Studies on molecular mechanisms of Ginkgo biloba extract Appl Microbiol Biotechnol 64 2004 465 472
17. F.V. DeFeudis A brief history of EGb 761 and its therapeutic uses Pharmacopsychiatry 36 Suppl 1 2003 S2 S7
18. A. Mdzinarishvili, R. Sumbria, and D. Lang Ginkgo extract EGb761 confers neuroprotection by reduction of glutamate release in ischemic brain J Pharm Pharm Sci 15 2012 94 102
19. Z. Zhang, D. Peng, and H. Zhu Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats Brain Res Bull 87 2012 193 198
20. S.E. Nada, and Z.A. Shah Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2 Neurobiol Dis 46 2012 180 189
21. L.H. Kuller, D.G. Ives, and A.L. Fitzpatrick Does Ginkgo biloba reduce the risk of cardiovascular events? Circ Cardiovasc Qual Outcomes 3 2010 41 47
22. X. Zeng, M. Liu, and Y. Yang Ginkgo biloba for acute ischaemic stroke Cochrane Database Syst Rev 4 2005 CD003691
23. P.R. Solomon, F. Adams, and A. Silver Ginkgo for memory enhancement: A randomized controlled trial JAMA 288 2002 835 840
24. J. Spilker, G. Kongable, and C. Barch Using the NIH Stroke Scale to assess stroke patients. The NINDS rt-PA Stroke Study Group J Neurosci Nurs 29 1997 384 392
25. W. Mack, J.R. Dusick, and N. Martin Principles of endovascular therapy R.B. Daroff, G.M. Fenichel, J. Jankovic, Bradley's neurology in clinical practice 6th ed. Principles of diagnosis and management Vol I 2012 Elsevier Saunders Philadelphia 828 829
26. M.M. Shoja, R.S. Tubbs, and G. Shokouhi The potential role of carbon dioxide in the neuroimmunoendocrine changes following cerebral ischemia Life Sci 83 2008 381 387
27. M.M. Shoja, P.S. Agutter, and R.S. Tubbs The role of the renin-angiotensin system in the pathogenesis of intracranial aneurysms J Renin Angiotensin Aldosterone Syst 12 2011 262 273
28. A. Taheraghdam, S. Aminnejad, and A. Pashapour Is there a correlation between hs-CRP levels and functional outcome of Ischemic Stroke? Pak J Med Sci 29 2013 166 169
29. I.A. Thanoon, H.A. Abdul-Jabbar, and D.A. Taha Oxidative stress and C-reactive protein in patients with cerebrovascular accident (ischaemic stroke): The role of Ginkgo biloba extract Sultan Qaboos Univ Med J 12 2012 197 205
30. M. Huang, Y. Qian, and T. Guan Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia Eur J Pharmacol 677 2012 71 76
31. Z.A. Shah, S.E. Nada, and S. Doré Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection Neuroscience 180 2011 248 255
32. S. Saleem, H. Zhuang, and S. Biswal Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury Stroke 39 2008 3389 3396
33. D. Lang, C. Kiewert, and A. Mdzinarishvili Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo Brain Res 1425 2011 155 163
34. Z.Z. Yang, J. Li, and S.X. Li Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats J Ethnopharmacol 136 2011 117 122
35. J.H. Cho, J.H. Sung, and E.H. Cho Gingko biloba extract (EGb 761) prevents ischemic brain injury by activation of the Akt signaling pathway Am J Chin Med 37 2009 547 555
36. S. Ma, H. Yin, and L. Chen Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats J Nat Med 66 2012 25 31
37. Y.G. Liu, F.J. Li, and J. Wang Effects of Ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats Zhong Yao Cai 33 2010 578 580
38. D. Lang, C. Ude, and M. Wurglics Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice J Pharm Pharm Sci 13 2010 607 614
39. J. Liu The use of Ginkgo biloba extract in acute ischemic stroke Explore (NY) 2 2006 262 263
40. F.V. Defeudis Bilobalide and neuroprotection Pharmacol Res 46 2002 565 568
41. B.J. Diamond, and M.R. Bailey Ginkgo biloba: Indications, mechanisms, and safety Psychiatr Clin North Am 36 2013 73 83
42. B.J. Diamond, S.C. Shiflett, and N. Feiwel Ginkgo biloba extract: Mechanisms and clinical indications Arch Phys Med Rehabil 81 2000 668 678
43. B. Vellas, N. Coley, and P.J. Ousset Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): A randomised placebo-controlled trial Lancet Neurol 11 2012 851 859
44. S. Kanowski, and R. Hoerr Ginkgo biloba extract EGb 761 in dementia: Intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial Pharmacopsychiatry 36 2003 297 303
45. P.L. Le Bars, M. Kieser, and K.Z. Itil A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761 in dementia Dement Geriatr Cogn Disord 11 2000 230 237