The role of the renin-angiotensin system in the pathogenesis of intracranial aneurysms

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 12, Issue 3, 2011, Pages 262-273

  Shoja, Mohammadali M ^a   Agutter, Paul S ^b   Tubbs, R Shane ^c   Payner, Troy D ^d   Ghabili, Kamyar ^a   Cohen Gadol, Aaron A ^d  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Theoretical Medicine and Biology Group   (United Kingdom)

^c CHILDREN S HOSPITAL   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Angiotensin receptors; brain; intracranial aneurysm; renin angiotensin system

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; OLMESARTAN; PRAVASTATIN; SODIUM; VASOCONSTRICTOR AGENT;

ALLELE; APOPTOSIS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR AUTOREGULATION; CELL ADHESION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENETIC POLYMORPHISM; HEALTH SURVEY; HUMAN; HYPERTENSION; IMMUNE RESPONSE; INFLAMMATION; INTRACRANIAL ANEURYSM; MEDICAL LITERATURE; MEDICAL RESEARCH; MOLECULAR DYNAMICS; PROTEIN DEGRADATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SMOOTH MUSCLE; SODIUM BALANCE; VASCULAR SMOOTH MUSCLE;

BRAIN; HUMANS; INTRACRANIAL ANEURYSM; RENIN-ANGIOTENSIN SYSTEM;

EID: 80052391732     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320310387845     Document Type: Review

References (132)

1. Lipper S., Morgan D., Krigman MR and Staab EV Congenital saccular aneurysm in a 19-day-old neonate: Case report and review of the literature. Surg Neurol 1978 ; 10: 161-165. (Pubitemid 9009794)
2. Wilkins RH Natural history of intracranial vascular malformations: A review. Neurosurgery 1985 ; 16: 421-430. (Pubitemid 15110015)
3. Nekrysh SY Association between heritable connective tissue disorders and intracranial aneurysms. Surg Neurol 2000 ; 54: 77-78.
4. Pfohman M. and Criddle LM Epidemiology of intracranial aneurysm and subarachnoid hemorrhage. J Neurosci Nurs 2001 ; 33: 39-41.
5. Wong G., Knuckey NW and Gubbay SS Subarachnoid haemorrhage in children caused by cerebral tumour. J Neurol Neurosurg Psychiatry 1983 ; 46: 449-450. (Pubitemid 13089382)
6. Brisman JL, Song JK and Newell DW Cerebral aneurysms. N Engl J Med 2006 ; 355: 928-939. (Pubitemid 44321760)
7. Clarke M. Systematic review of reviews of risk factors for intracranial aneurysms. Neuroradiology 2008 ; 50: 653-664.
8. Jeong YG, Jung YT, Kim MS, Eun CK and Jang SH Size and location of ruptured intracranial aneurysms. J Korean Neurosurg Soc 2009 ; 45: 11-15.
9. Nahed BV, DiLuna ML, Morgan T., Ocal E., Hawkins AA, Ozduman K., et al. Hypertension, age, and location predict rupture of small intracranial aneurysms. Neurosurgery 2005 ; 57: 676-683.
10. Sekhar LN and Heros RC Origin, growth, and rupture of saccular aneurysms: A review. Neurosurgery 1981 ; 8: 248-260. (Pubitemid 11142244)
11. Scanlon A. Aneurysmal subarachnoid haemorrhage - part 1: Pre-operative nursing management diagnosis, complications and treatment: A composite case study. Contemp Nurse 2004 ; 17: 80-88.
12. Morita A., Fujiwara S., Hashi K., Ohtsu H. and Kirino T. Risk of rupture associated with intact cerebral aneurysms in the Japanese population: A systematic review of the literature from Japan. J Neurosurg 2005 ; 102: 601-606. (Pubitemid 43186662)
13. Wermer MJ, van der Schaaf IC, Algra A. and Rinkel GJ Risk of rupture of unruptured intracranial aneurysms in relation to patient and aneurysm characteristics: An updated meta-analysis. Stroke 2007 ; 38: 1404-1410. (Pubitemid 351664233)
14. Keedy A. An overview of intracranial aneurysms. McGill J Med 2006 ; 9: 141-146. (Pubitemid 44735580)
15. Schonfeld AR and McMullen MA Treatment of brain aneurysms. Radiol Technol 2008 ; 79: 515-531.
16. Burns JD and Brown RD Jr. Treatment of unruptured intracranial aneurysms: surgery, coiling, or nothing? Curr Neurol Neurosci Rep 2009 ; 9: 6-12.
17. Yong-Zhong G. and van Alphen HA Pathogenesis and histopathology of saccular aneurysms: Review of the literature. Neurol Res 1990 ; 12: 249-255.
18. Kassell NF, Sasaki T., Colohan AR and Nazar G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 1985 ; 16: 562-572. (Pubitemid 15007226)
19. Selman WR, Tarr RW and Ratcheson RA Intracranial aneurysms and subarachnoid hemorrhage. In: Bradley WG, Daroff RB, Fenichel GM (eds) Neurology in Clinical Practice. 3d ed. Boston: Butterworth-Heinemann, 2000, pp. 1188-1190.
20. Inci S. and Spetzler RF Intracranial aneurysms and arterial hypertension: A review and hypothesis. Surg Neurol 2000 ; 53: 530-540.
21. Ellison D. and Love S. Subarachnoid Hemorrhage. In: Neuropathology: A Reference Text of CNS Pathology. St. Louis: Mosby ; 1998, 10.3-10.8.
22. Zhou X., Ji WJ, Tu Y., Yao M. and Li YM Abdominal aortic aneurysm and cerebral aneurysm present different pathological evolutions and responses to pharmacological therapy. Med Hypotheses 2007 ; 68: 601-606. (Pubitemid 46037971)
23. Humphrey JD and Taylor CA Intracranial and abdominal aortic aneurysms: Similarities, differences, and need for a new class of computational models. Annu Rev Biomed Eng 2008 ; 10: 221-246.
24. Norman PE and Powell JT Site specificity of aneurismal disease. Circulation 2010 ; 121: 560-568.
25. Nixon AM, Gunel M. and Sumpio BE The critical role of hemodynamics in the development of cerebral vascular disease. J Neurosurg 2010 ; 112: 1240-1253.
26. Nuki Y., Tsou TL, Kurihara C., Kanematsu M., Kanematsu Y. and Hashimoto T. Elastase-induced intracranial aneurysms in hypertensive mice. Hypertension 2009 ; 54: 1337-1344.
27. Aoki T., Kataoka H., Moriwaki T., Nozaki K. and Hashimoto N. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Stroke 2007 ; 38: 2337-2345. (Pubitemid 47457578)
28. Jayaraman T., Berenstein V., Li X., Mayer J., Silane M., Shin YS, et al. Tumor necrosis factor alpha is a key modulator of inflammation in cerebral aneurysms. Neurosurgery 2005 ; 57: 558-564.
29. Kilic T., Sohrabifar M., Kurtkaya O., Yildirim O., Elmaci I., Günel M., et al. Expression of structural proteins and angiogenic factors in normal arterial and unruptured and ruptured aneurysm walls. Neurosurgery 2005 ; 57: 997-1007.
30. Gallo GL and Tamargo R. Leukocyte-endothelial cell interactions in chronic vasospasm after subarachnoid hemorrhage. Neurol Res 2006 ; 28: 750-758. (Pubitemid 44656101)
31. Aoki T., Kataoka H., Shimamura M., Nakagami H., Moriwaki T., Ishibashi R., et al. NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation 2007 ; 116: 2830-2840. (Pubitemid 350291225)
32. Aoki T., Kataoka H., Ishibashi R., Nozaki K., Morishita R. and Hashimoto N. Reduced collagen biosynthesis is the hallmark of cerebral aneurysm: Contribution of interleukin-1beta and nuclear factor-kappaB. Arterioscler Thromb Vasc Biol 2009 ; 29: 1080-1086.
33. Aoki T. and Nishimura M. Targeting chronic inflammation in cerebral aneurysms: Focusing on NF-kappaB as a putative target of medical therapy. Expert Opin Ther Targets 2010 ; 14: 265-273.
34. Boullin DJ, Brandt L., Ljunggren B. and Tagari P. Vasoconstrictor activity in cerebrospinal fluid from patients subjected to early surgery for ruptured intracranial aneurysms. J Neurosurg 1981 ; 55: 237-245. (Pubitemid 11034238)
35. Zhang W., Liu AJ, Yi- Ming W., Liu JG, Shen FM and Su DF Pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 2008 ; 35: 83-88. (Pubitemid 350197685)
36. Keramatipour M., McConnell RS, Kirkpatrick P., Tebbs S., Furlong RA and Rubinsztein DC The ACE I allele is associated with increased risk for ruptured intracranial aneurysms. J Med Genet 2000 ; 37: 498-500. (Pubitemid 30428235)
37. Coutard M., Huang W. and Osborne-Pellegrin M. Heritability of intracerebral hemorrhagic lesions and cerebral aneurysms in the rat. Stroke 2000 ; 31: 2678-2684.
38. Nahed BV, Bydon M., Ozturk AK, Bilguvar K., Bayrakli F. and Günel M. Genetics of intracranial aneurysms. Neurosurgery 2007 ; 60: 213-225.
39. Peck G., Smeeth L., Whittaker J., Casas JP, Hingorani A. and Sharma P. The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS One 2008 ; 3: e3691.
40. Yasuno K., Bilguvar K., Bijlenga P., Low SK, Krischek B., Auburger G., et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 2010 ; 42: 420-425.
41. Schievink WI, Schaid DJ, Rogers HM, Piepgras DG and Michels VV On the inheritance of intracranial aneurysms. Stroke 1994 ; 25: 2028-2037. (Pubitemid 24291292)
42. Lozano AM and Leblanc R. Familial intracranial aneurysms. J Neurosurg 1987 ; 66: 522-528. (Pubitemid 17059506)
43. Foroud T., Sauerbeck L., Brown R., Anderson C., Woo D., Kleindorfer D., et al. Genome screen in familial intracranial aneurysm. BMC Med Genet 2009 ; 10: 3.
44. Zhang J. and Claterbuck RE Molecular genetics of human intracranial aneurysms. Int J Stroke 2008 ; 3: 272-287.
45. Ruigrok YM, Wijmenga C., Rinkel GJ, van't Slot R., Baas F., Wolfs M., et al. Genomewide linkage in a large Dutch family with intracranial aneurysms: Replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke 2008 ; 39: 1096-1102. (Pubitemid 351440675)
46. Roos YB, Pals G., Struycken PM, Rinkel GJ, Limburg M., Pronk JC, et al. Genome-wide linkage in a large Dutch con-sanguineous family maps a locus for intracranial aneurysms to chromosome 2p13. Stroke 2004 ; 35: 2276-2281. (Pubitemid 39311249)
47. Bilguvar K., Yasuno K., Niemelä M., Ruigrok YM, von Und Z. u Fraunberg M., van Duijn CM, et al. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 2008 ; 40: 1472-1477.
48. Farnham JM, Camp NJ, Neuhausen SL, Tsuruda J., Parker D., MacDonald J., et al. Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet 2004 ; 114: 250-255. (Pubitemid 38208302)
49. Onda H., Kasuya H., Yoneyama T., Takakura K., Hori T., Takeda J., et al. Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11. Am J Hum Genet 2001 ; 69: 804-819. (Pubitemid 32868525)
50. Helgadottir A., Thorleifsson G., Magnusson KP, Grétarsdottir S., Steinthorsdottir V., Manolescu A., et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008 ; 40: 217-224. (Pubitemid 351171400)
51. Ozturk AK, Nahed BV, Bydon M., Bilguvar K., Goksu E., Bademci G., et al. Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31. Stroke 2006 ; 37: 1021-1027.
52. Mineharu Y., Inoue K., Inoue S., Kikuchi K., Ohishi H., Nozaki K., et al. Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23. J Hum Genet 2008 ; 53: 325-332.
53. Yamada S., Utsunomiya M., Inoue K., Nozaki K., Inoue S., Takenaka K., et al. Genome-wide scan for Japanese familial intracranial aneurysms: Linkage to several chromosomal regions. Circulation 2004 ; 110: 3727-3733. (Pubitemid 39665264)
54. Olson JM, Vongpunsawad S., Kuivaniemi H., Ronkainen A., Hernesniemi J., Ryynänen M., et al. Search for intracranial aneurysm susceptibility gene(s) using Finnish families. BMC Med Genet 2002 ; 3: 7.
55. Ruigrok YM, Rinkel GJ, Wijmenga C., Kasuya H., Tajima A., Takahashi T., et al. Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. Cerebrovasc Dis 2009 ; 28: 131-134.
56. Pera J., Korostynski M., Krzyszkowski T., Czopek J., Slowik A., Dziedzic T., et al. Gene expression profiles in human ruptured and unruptured intracranial aneurysms: What is the role of inflammation? Stroke 2010 ; 41: 224-231.
57. Li L., Yang X., Jiang F., Dusting GJ and Wu Z. Transcriptomewide characterization of gene expression associated with unruptured intracranial aneurysms. Eur Neurol 2009 ; 62: 330-337.
58. Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K., Massin P., et al. Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 2006 ; 354: 1489-1496.
59. Plaisier E., Gribouval O., Alamowitch S., Mougenot B., Prost C., Verpont MC, et al. COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N Engl J Med 2007 ; 357: 2687-2695.
60. Shi C., Awad IA, Jafari N., Lin S., Du P., Hage ZA, et al. Genomics of human intracranial aneurysm wall. Stroke 2009 ; 40: 1252-1261.
61. Baas AF, Medic J., van't Slot R., de Vries JP, van Sambeek MR, Verhoeven EL, et al. The intracranial aneurysm susceptibility genes HSPG2 and CSPG2 are not associated with abdominal aortic aneurysm. Angiology 2010 ; 61: 238-242.
62. Brooks DP and Ruffolo RR Functions mediated by peripheral angiotensin II receptors. In: Ruffolo RR (ed.) Angiotensin II Receptors, Vol 1: Molecular Biology, Biochemistry, Pharmacology and Clinical Perspectives. Boca Raton: CRC Press, 1994, pp. 71-102.
63. Drenjancevic-Peric I., Phillips SA, Falck JR and Lombard JH Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats. Am J Physiol Heart Circ Physiol 2005 ; 289: H188-195.
64. Ohkuma H., Suzuki S., Fujita S. and Nakamura W. Role of a decreased expression of the local renin-angiotensin system in the etiology of cerebral aneurysms. Circulation 2003 ; 108: 785-787. (Pubitemid 37022117)
65. Mehta PK and Griendling KK Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007 ; 292: C82-97.
66. Daugherty A. and Cassis L. Angiotensin II and abdominal aortic aneurysms. Curr Hypertens Rep 2004 ; 6: 442-446. (Pubitemid 39600100)
67. Cassis LA, Helton MJ, Howatt DA, King VL and Daugherty A. Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Br J Pharmacol 2005 ; 144: 443-448. (Pubitemid 40313692)
68. Basso N. and Terragno NA History about the discovery of the renin-angiotensin system. Hypertension 2001 ; 38: 1256-1259.
69. Ménard J., Bouhnik J., Clauser E., Richoux JP and Corvol P. Biochemistry and regulation of angiotensinogen. Clin Exp Hypertens A 1983 ; 5: 1005-1019. (Pubitemid 13013690)
70. Haber E. and Burton J. Inhibitors of renin and their utility in physiologic studies. Fed Proc 1979 ; 38: 2768-2773. (Pubitemid 10173167)
71. Fyhrquist F. and Saijonmaa O. Renin-angiotensin system revisited. J Intern Med 2008 ; 264: 224-236.
72. Campbell DJ Circulating and tissue angiotensin systems. J Clin Invest 1987 ; 79: 1-6. (Pubitemid 17232490)
73. Tirapelli CR, Fukada SY, de Godoy MA and de Oliveira AM Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid. Life Sci 2006 ; 78: 2676-2682.
74. Pueyo ME and Michel JB Angiotensin II receptors in endothelial cells. Gen Pharmacol 1997 ; 29: 691-696. (Pubitemid 27475151)
75. Shelat SG, Flanagan-Cato LM and Fluharty SJ Glucocorticoid and mineralocorticoid regulation of angiotensin II type 1 receptor binding and inositol triphosphate formation in WB cells. J Endocrinol 1999 ; 162: 381-391. (Pubitemid 29447431)
76. Brock TA, Alexander RW, Ekstein LS, Atkinson WJ and Gimbrone MA Jr. Angiotensin increases cytosolic free calcium in cultured vascular smooth muscle cells. Hypertension 1985 ; 7: 1105-109.
77. Geisterfer AA, Peach MJ and Owens GK Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 1988 ; 62: 749-756.
78. Antonaccio MJ Angiotensin converting enzyme (ACE) inhibitors. Annu Rev Pharmacol Toxicol 1982 ; 22: 57-87.
79. Saavedra JM Brain angiotensin II: New developments, unanswered questions and therapeutic opportunities. Cell Mol Neurobiol 2005 ; 25: 485-512. (Pubitemid 41199709)
80. Pueyo ME, Arnal JF, Rami J. and Michel JB Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells. Am J Physiol 1998 ; 274: C214-220.
81. Tamura T., Jamous MA, Kitazato KT, Yagi K., Tada Y., Uno M., et al. Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats. J Hypertens 2009 ; 27: 1284-1292.
82. Yayama K. and Okamoto H. Angiotensin II-induced vasodilation via type 2 receptor: Role of bradykinin and nitric oxide. Int Immunopharmacol 2008 ; 8: 312-318.
83. Cornwell TL, Arnold E., Boerth NJ and Lincoln TM Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol 1994 ; 267: C1405-1413.
84. Schulman IH and Raij L. The angiotensin II type 2 receptor: What is its clinical significance? Curr Hypertens Rep 2008 ; 10: 188-193.
85. Goodfriend TL and Peach MJ Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin-angiotensin system. Circ Res 1975 ; 36 (6 Suppl 1). 38-48.
86. Gallagher PE, Ferrario CM and Tallant EA MAP kinase/ phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol 2008 ; 295: C1169-1174.
87. Ganten D., Hermann K., Unger T. and Lang RE The tissue renin-angiotensin systems: Focus on brain angiotensin, adrenal gland and arterial wall. Clin Exp Hypertens A 1983 ; 5: 1099-1118. (Pubitemid 13013696)
88. Haberl RL, Decker-Hermann PJ and Hermann K. Effect of renin on brain arterioles and cerebral blood flow in rabbits. J Cereb Blood Flow Metab 1996 ; 16: 714-719. (Pubitemid 26227082)
89. Muders F., Palkovits M., Bahner U., Kirst I., Elsner D. and Jandeleit-Dahm K. Central inhibition of AT1receptors by eprosartan - in vitro autoradiography in the brain. Pharmacol Res 2001 ; 43: 251-255. (Pubitemid 32601432)
90. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, et al. The brain renin-angiotensin system: Location and physiological roles. Int J Biochem Cell Biol 2003 ; 35: 901-918. (Pubitemid 36379330)
91. Nguyen G., Burckle C. and Sraer JD The renin receptor: The facts, the promise and the hope. Curr Opin Nephrol Hypertens 2003 ; 12: 51-55. (Pubitemid 36092315)
92. Baudin B., Berard M., Carrier JL, Legrand Y. and Drouet L. Vascular origin determines angiotensin I-converting enzyme expression in endothelial cells. Endothelium 1997 ; 5: 73-84. (Pubitemid 27165891)
93. Maktabi MA, Todd MM and Stachovic G. Angiotensin II contributes to cerebral vasodilatation during hypoxia in the rabbit. Stroke 1995 ; 26: 1871-1876.
94. Mathias CJ Role of the central nervous system in human secondary hypertension. J Cardiovasc Pharmacol 1987 ; 10 (Suppl 12). S93-99.
95. Yamamoto K., Ueno Y., Arita M., Suruda H., Hano T. and Masuyama Y. Contributions of the sympathetic nervous system, vasopressin and baroreceptor function in brain angiotensin II excess-induced hypertension in the dog. Clin Exp Hypertens A 1988 ; 10 (Suppl 1). 309-316. (Pubitemid 19078428)
96. Wei SG and Felder RB Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity. Am J Physiol Heart Circ Physiol 2002 ; 282: H890-895.
97. Lochard N., Silversides DW, van Kats JP, Mercure C. and Reudelhuber TL Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J Biol Chem 2003 ; 278: 2184-2189. (Pubitemid 36801284)
98. Brooks VL, Keil LC and Reid IA Role of the renin- angiotensin system in the control of vasopressin secretion in conscious dogs. Circ Res 1986 ; 58: 829-838. (Pubitemid 16094212)
99. Reaux A., Iturrioz X., Vazeux G., Fournie-Zaluski MC, David C., Roques BP, et al. Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans 2000 ; 28: 435-440.
100. Head GA, Saigusa T. and Mayorov DN Angiotensin and baroreflex control of the circulation. Braz J Med Biol Res 2002 ; 35: 1047-1059. (Pubitemid 35476803)
101. Fitzsimons JT The effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin II injected into the rat's diencephalon. J Physiol 1971 ; 214: 295-303.
102. Zhang Y., Lu J., Shi J., Lin X., Dong J., Zhang S., et al. Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats. Neuropeptides 2008 ; 42: 593-600.
103. Feterik K., Smith L. and Katusic ZS Angiotensin-(1-7) causes endothelium-dependent relaxation in canine middle cerebral artery. Brain Res 2000 ; 873: 75-82. (Pubitemid 30468487)
104. Tonnaer JA, Wiegant VM, de Jong W. and De Wied D. Central effects of angiotensins on drinking and blood pressure: Structure-activity relationships. Brain Res 1982 ; 236: 417-428. (Pubitemid 12132562)
105. Francis J., Wei SG, Weiss RM and Felder RB Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure. Am J Physiol Heart Circ Physiol 2004 ; 287: H2138-146.
106. Saavedra JM, Benicky J. and Zhou J. Mechanisms of the anti-ischemic effect of angiotensin II AT(1) receptor antagonists in the brain. Cell Mol Neurobiol 2006 ; 26: 1099-1111. (Pubitemid 44924033)
107. Kaliszewski C., Fernandez LA and Wicke JD Differences in mortality rate between abrupt and progressive carotid ligation in the gerbil: Role of endogenous angiotensin II. J Cereb Blood Flow Metab 1988 ; 8: 149-154. (Pubitemid 18079682)
108. Waldemar G. and Paulson OB Angiotensin converting enzyme inhibition and cerebral circulation - a review. Br J Clin Pharmacol 1989 ; 28 (Suppl 2). 177-182 S.
109. Paulson OB and Waldemar G. Role of the local renin- angiotensin system in the autoregulation of the cerebral circulation. Blood Vessels 1991 ; 28: 231-235.
110. Paulson OB, Waldemar G., Andersen AR, Barry DI, Pedersen EV, Schmidt JF, et al. Role of angiotensin in autoregulation of cerebral blood flow. Circulation 1988 ; 77: 155-58.
111. Krejcy K., Wolzt M., Kreuzer C., Breiteneder H., Schütz W., Eichler HG, et al. Characterization of angiotensin-II effects on cerebral and ocular circulation by noninvasive methods. Br J Clin Pharmacol 1997 ; 43: 501-508. (Pubitemid 27224010)
112. Teruya H., Muratani H., Takishita S., Sesoko S., Matayoshi R. and Fukiyama K. Brain angiotensin II contributes to the development of hypertension in Dahl-Iwai salt-sensitive rats. J Hypertens 1995 ; 13: 883-890.
113. Nishimura M., Milsted A., Block CH, Brosnihan KB and Ferrario CM Tissue renin-angiotensin systems in renal hypertension. Hypertension 1992 ; 20: 158-167.
114. Doursout MF, Chelly JE, Liang YY and Buckley JP The ouabain-dependent Na(+)-K+ pump and the brain renin-angiotensin system. Clin Exp Hypertens A 1992 ; 14: 393-411.
115. Leenen FH, Yuan B. and Huang BS Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction. Am J Physiol 1999 ; 277: H1786-1792.
116. Zhang W., Huang BS AND Leenen FH Brain renin- angiotensin system and sympathetic hyperactivity in rats after myocardial infarction. Am J Physiol 1999 ; 276: H1608-1615.
117. Zera T., Ufnal M and Szczepanska-Sadowska E. Central TNF-alpha elevates blood pressure and sensitizes to central pressor action of angiotensin II in the infracted rats. J Physiol Pharmacol 2008 ; 59 (Suppl 8). 117-121.
118. Pannu H., Tran-Fadulu V. and Milewicz DM Genetic basis of thoracic aortic aneurysms and aortic dissections. Am J Med Genet C Semin Med Genet 2005 ; 139C: 10-16. (Pubitemid 41739242)
119. Slowik A., Borratynska A., Pera J., Betlej M., Dziedzic T., Krzyszkowski T., et al. II genotype of the angiotensin-converting enzyme gene increases the risk for subarachnoid hemorrhage from ruptured aneurysm. Stroke 2004 ; 35: 1594-1597. (Pubitemid 38823631)
120. Takenaka K., Yamakawa H., Sakai H., Yoshimura S., Murase S., Okumura A., et al. Angiotensin I-converting enzyme gene polymorphism in intracranial saccular aneurysm individuals. Neurol Res 1998 ; 20: 607-611. (Pubitemid 28440007)
121. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P. and Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990 ; 86: 1343-1346. (Pubitemid 20370444)
122. Kimura N., Shimizu H., Eldawoody H., Nakayama T., Saito A., Tominaga T., et al. Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats. Brain Res 2010 ; 1322: 144-152.
123. Agata J., Ura N., Yoshida H., Shinshi Y., Sasaki H., Hyakkoku M., et al. Olmesartan is an angiotensin II receptor blocker with an inhibitory effect on angiotensin-converting enzyme. Hypertens Res 2006 ; 29: 865-874. (Pubitemid 46062117)
124. Matsumoto S., Shimodozono M., Miyata R. and Kawahira K. Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke. Hypertens Res 2009 ; 32: 1015-1021.
125. Krikov M., Thone-Reineke C., Müller S., Villringer A. and Unger T. Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats. J Hypertens 2008 ; 26: 544-552. (Pubitemid 351317265)
126. Emsley HC and Tyrrell PJ Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab 2002 ; 22: 1399-1419. (Pubitemid 35424925)
127. Zhao Q., Ishibashi M., Hiasa K., Tan C., Takeshita A. and Egashira K. Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling. Hypertension 2004 ; 44: 264-270. (Pubitemid 39172204)
128. Benicky J., Sánchez-Lemus E., Pavel J. and Saavedra JM Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery. Cell Mol Neurobiol 2009 ; 29: 781-792.
129. Aoki T., Nishimura M., Kataoka H., Ishibashi R., Miyake T., Takagi Y., et al. Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. Int J Mol Med 2009 ; 24: 353-359.
130. Tada Y., Kitazato KT, Tamura T., Yagi K., Shimada K., Kinouchi T., et al. Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. Hypertension 2009 ; 54: 552-557.
131. Berendes E., Walter M., Cullen P., Prien T., Van Aken H., Horsthemke J., et al. Secretion of brain natriuretic peptide in patients with aneurismal subarachnoid haemorrhage. Lancet 1997 ; 349: 245-249. (Pubitemid 27050991)
132. Sawada K., Maehara T., Inaji M., Toriyama H., Okada T., Nariai T., et al. Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism. No Shinkei Geka 2010 ; 38: 347-351.