Chemotype-selective modes of action of κ-opioid receptor agonists

Journal of Biological Chemistry

Volumn 288, Issue 48, 2013, Pages 34470-34483

  Vardy, Eyal ^a   Mosier, Philip D ^b   Frankowski, Kevin J ^c   Wu, Huixian ^d   Katritch, Vsevolod ^d   Westkaemper, Richard B ^b   Aubé, Jeffrey ^c   Stevens, Raymond C ^d   Roth, Bryan L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; AGONIST BINDING SITE; FUNCTIONAL ASSAYS; MOLECULAR DETERMINANTS; OPIOID RECEPTORS; RECEPTOR ACTIVATION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ACTIVATION ANALYSIS; BINDING ENERGY; ENZYME ACTIVITY; ESSENTIAL OILS;

LIGANDS;

DYNORPHIN A; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; OCTAHYDROISOQUINOLINONE CARBOXAMIDE DERIVATIVE; SALVINORIN A; UNCLASSIFIED DRUG; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR DOCKING; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

EID: 84889011912     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515668     Document Type: Article

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