Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the k-opioid receptor does not affect dynorphin A(1-13) affinity and function [1]

Journal of Medicinal Chemistry

Volumn 43, Issue 7, 2000, Pages 1251-1252

  Ferguson, David M ^b   Kramer, Stacy ^b   Metzger, Thomas G ^b   Law, Ping Y ^a   Portoghese, Philip S ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIPRENORPHINE; DYNORPHIN[1-13]; KAPPA OPIATE RECEPTOR; NORBINALTORPHIMINE;

BINDING AFFINITY; BINDING COMPETITION; HYDROPHOBICITY; LETTER; LIGAND BINDING; POINT MUTATION; PROTEIN MODIFICATION; RECEPTOR BINDING;

AMINO ACID SEQUENCE; CELL LINE; DYNORPHINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POINT MUTATION; POLYMERASE CHAIN REACTION; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034611604     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990583r     Document Type: Letter

References (12)

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