Moderate and high amounts of tamoxifen in αmHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

DMM Disease Models and Mechanisms

Volumn 6, Issue 6, 2013, Pages 1459-1469

  Bersell, Kevin ^a   Choudhury, Sangita ^a,b   Mollova, Mariya ^a,b   Polizzotti, Brian D ^a,b   Ganapathy, Balakrishnan ^a   Walsh, Stuart ^a,b   Wadugu, Brian ^a   Arab, Shima ^a   Kühn, Bernhard ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; MYOSIN HEAVY CHAIN; PROTEIN P53; TAMOXIFEN;

ADENOVIRUS; ARTICLE; BODY WEIGHT; CELL SURVIVAL; DEATH; DNA DAMAGE; DNA STRAND BREAKAGE; GENETIC REGULATION; HEART FAILURE; HEART MUSCLE FIBROSIS; HOMOLOGOUS RECOMBINATION; LETHALITY; LOXP SITE; MYOCARDIAL DISEASE; PRIORITY JOURNAL; PROMOTER REGION; SMOOTH MUSCLE; TRANSGENE;

ANIMALS; APOPTOSIS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART FAILURE; MICE; MYOCYTES, CARDIAC; SURVIVAL ANALYSIS; TAMOXIFEN;

EID: 84888880795     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.010447     Document Type: Article

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