Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: Parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study)

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 12, 2011, Pages

  Schafer, Anne L ^a,b   Sellmeyer, Deborah E ^c   Schwartz, Ann V ^a   Rosen, Clifford J ^d   Vittinghoff, Eric ^a   Palermo, Lisa ^a   Bilezikian, John P ^e   Shoback, Dolores M ^a,b   Black, Dennis M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Maine Medical Center Research Institute   (United States)

^e New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALENDRONIC ACID; CALCIUM CARBONATE; GLUCOSE; INSULIN; OSTEOCALCIN; PARATHYROID HORMONE; VITAMIN D;

ADULT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MORNING DOSAGE; OSTEOPOROSIS; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TREATMENT RESPONSE; WEIGHT CHANGE;

ADIPONECTIN; ADIPOSITY; AGED; AGED, 80 AND OVER; ALENDRONATE; BODY WEIGHT; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; PARATHYROID HORMONE;

EID: 83155168441     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0587     Document Type: Article

References (20)

1. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais- Jarvis F, Ducy P, Karsenty G 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-469
2. Ferron M, Hinoi E, Karsenty G, Ducy P 2008 Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266-5270 (Pubitemid 351738545)
3. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T 2009 Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:45-49
4. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B 2009 Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 94:827-832
5. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D 2009 Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 24:785-791
6. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Beilby JP, Norman PE 2010 Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. Eur J Endocrinol 163:265-272
7. Zhou M, Ma X, Li H, Pan X, Tang J, Gao Y, Hou X, Lu H, Bao Y, Jia W 2009 Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur J Endocrinol 161: 723-729
8. Im JA, Yu BP, Jeon JY, Kim SH 2008 Relationship between osteo-calcin and glucose metabolism in postmenopausal women. Clin Chim Acta 396:66-69
9. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yaho S, Sugimoto T 2011 Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22:187-194
10. Hirao M, Hashimoto J, Ando W, Ono T, Yoshikawa H 2008 Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women. J Bone Miner Metab 26:260-264 (Pubitemid 351677843)
11. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ 2003 The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349: 1207-1215 (Pubitemid 37152030)
12. Sellmeyer DE, Black DM, Palermo L, Greenspan S, Ensrud K, Bilezikian J, Rosen CJ 2007 Heterogeneity in skeletal response to full-length parathyroid hormone in the treatment of osteoporosis. Osteoporos Int 18:973-979 (Pubitemid 46889557)
13. Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD 1997 Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. J Clin Endocrinol Metab 82:719-724 (Pubitemid 27106576)
14. Gundberg CM, Nieman SD, Abrams S, Rosen H 1998 Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83:3258-3266 (Pubitemid 28500970)
15. Kaptoge S, Dalzell N, Folkerd E, Doody D, Khaw KT, Beck TJ, Loveridge N, Mawer EB, Berry JL, Shearer MJ, Dowsett M, Reeve J 2007 Sex hormone status may modulate rate of expansion of proximal femur diameter in older women alongside other skeletal regulators. J Clin Endocrinol Metab 92:304-313
16. Conway SP, Wolfe SP, Brownlee KG, White H, Oldroyd B, Truscott JG, Harvey JM, Shearer MJ 2005 Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Pediatrics 115:1325-1331 (Pubitemid 43843239)
17. Foresta C, Strapazzon G, DeToni L, Gianesello L, Calcagno A, Pilon C, Plebani M, Vettor R 2010 Evidence for osteocalcin production by adipose tissue and its role in human metabolism. J Clin Endocrinol Metab 95:3502-3506
18. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM 2001 Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86:3815-3819 (Pubitemid 32755982)
19. Faraj M, Havel PJ, Phélis S, Blank D, Sniderman AD, Cianflone K 2003 Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 88:1594-1602 (Pubitemid 36623375)
20. Anastasilakis AD, Efstathiadou Z, Plevraki E, Koukoulis GN, Slavakis A, Kita M, Avramidis A 2008 Effect of exogenous intermittent recombinant human PTH 1-34 administration and chronic endogenous parathyroid hormone excess on glucose homeostasis and insulin sensitivity. Horm Metab Res 40:702-707