T cell responses in dengue viral infections

Journal of Clinical Virology

Volumn 58, Issue 4, 2013, Pages 605-611

  Malavige, Gathsaurie Neelika ^a,b   Ogg, Graham S ^b,c  

^a UNIVERSITY OF SRI JAYEWARDENEPURA   (Sri Lanka)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Cytokines; Dengue viral infection; Pathogenesis; T cells; Vascular leak

Indexed keywords

DENGUE VACCINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5;

APOPTOSIS; ASYMPTOMATIC INFECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CONVALESCENCE; CROSS REACTION; CYTOKINE PRODUCTION; DEGRANULATION; DENDRITIC CELL; DENGUE; DISEASE SEVERITY; DISEASES; HEREDITY; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; JAPANESE ENCEPHALITIS VIRUS; LYMPHOCYTE COUNT; MEMORY T LYMPHOCYTE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SEROTYPE; T LYMPHOCYTE; VACCINATION; VIREMIA; VIRUS LOAD;

CYTOKINES; DENGUE VIRAL INFECTION; PATHOGENESIS; T CELLS; VASCULAR LEAK;

CYTOKINES; DENGUE; HUMANS; T-LYMPHOCYTES;

EID: 84888836723     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2013.10.023     Document Type: Review

References (59)

1. Global strategy for dengue prevention and control 2012-2020 2012, World Health Organization.
2. Bhatt S., Gething P.W., Brady O.J., Messina J.P., Farlow A.W., Moyes C.L., et al. The global distribution and burden of dengue. Nature 2013 April 25, 496(7446):504-507. [Epub 2013/04/09].
3. Comprehensive guidelines for prevention and control of dengue fever and dengue haemorrhagic fever 2011, World Health Organization, Geneva, Switzerland.
4. Thomas S.J., Endy T.P. Critical issues in dengue vaccine development. Current Opinion in Infectious Diseases 2011, 24(5):442-450.
5. Halstead S.B. Dengue vaccine development: a 75% solution?. Lancet 2012, 380(9853):1535-1536. [Epub 2012/09/15].
6. Weaver S.C., Vasilakis N. Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease. Infection, Genetics and Evolution 2009, 9(4):523-540.
7. Malavige G.N., Fernando S., Fernando D.J., Seneviratne S.L. Dengue viral infections. Postgraduate Medical Journal 2004, 80(948):588-601.
8. Mathew A., Rothman A.L. Understanding the contribution of cellular immunity to dengue disease pathogenesis. Immunological Reviews 2008, 225:300-313.
9. Martina B.E., Koraka P., Osterhaus A.D. Dengue virus pathogenesis: an integrated view. Clinical Microbiology Reviews 2009, 22(4):564-581.
10. WHO Dengue guidelines for diagnosis, prevention and control 2009, World Health Organisation, Geneva. New edition.
11. Lin C.F., Lei H.Y., Shiau A.L., Liu C.C., Liu H.S., Yeh T.M., et al. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. Journal of Medical Virology 2003, 69(1):82-90.
12. Chase A.J., Medina F.A., Munoz-Jordan J.L. Impairment of CD4+ T cell polarization by dengue virus-infected dendritic cells. The Journal of Infectious Diseases 2011, 203(12):1763-1774. [Epub 2011/05/25].
13. Appanna R., Ponnampalavanar S., Lum Chai See L., Sekaran S.D. Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population. PLoS ONE 2010, 5(9):e13029.
14. Malavige G.N., Rostron T., Rohanachandra L.T., Jayaratne S.D., Fernando N., De Silva A.D., Liyanage M., Ogg G.S. HLA class I and class II associations in dengue viral infections in a Sri Lankan population. PLoS ONE 2011, 6(6):e20581.
15. Midgley C.M., Bajwa-Joseph M., Vasanawathana S., Limpitikul W., Wills B., Flanagan A., et al. An in-depth analysis of original antigenic sin in dengue virus infection. Journal of Virology 2011, 85(1):410-421. [Epub 2010/10/29].
16. Mongkolsapaya J., Dejnirattisai W., Xu X.N., Vasanawathana S., Tangthawornchaikul N., Chairunsri A., et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nature Medicine 2003, 9(7):921-927.
17. Halstead S.B. Controversies in dengue pathogenesis. Paediatrics and International Child Health 2012, 32(1):5-9. [Epub 2012/06/08].
18. Simmons C.P., Dong T., Chau N.V., Dung N.T., Chau T.N., Thao le T.T., et al. Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections. Journal of Virology 2005, 79(9):5665-5675.
19. Appanna R., Huat T.L., See L.L., Tan P.L., Vadivelu J., Devi S. Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia. Clinical and Vaccine Immunology 2007, 14(8):969-977.
20. Weiskopf D., Angelo M.A., de Azeredo E.L., Sidney J., Greenbaum J.A., Fernando A.N., et al. Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America 2013, 110(22):E2046-E2053. [Epub 2013/04/13].
21. Moran E., Simmons C., Vinh Chau N., Luhn K., Wills B., Dung N.P., et al. Preservation of a critical epitope core region is associated with the high degree of flaviviral cross-reactivity exhibited by a dengue-specific CD4+ T cell clone. European Journal of Immunology 2008, 38(4):1050-1057.
22. Duangchinda T., Dejnirattisai W., Vasanawathana S., Limpitikul W., Tangthawornchaikul N., Malasit P., et al. Immunodominant T-cell responses to dengue virus NS3 are associated with DHF. Proceedings of the National Academy of Sciences of the United States of America 2011, 107(39):16922-16927.
23. Livingston P.G., Kurane I., Dai L.C., Okamoto Y., Lai C.J., Men R., et al. Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities. Journal of Immunology 1995, 154(3):1287-1295.
24. Rivino L., Kumaran E.A., Jovanovic V., Nadua K., Teo E.W., Pang S.W., et al. Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection. Journal of Virology 2013, 87(5):2693-2706. [Epub 2012/12/21].
25. Imrie A., Meeks J., Gurary A., Sukhbataar M., Kitsutani P., Effler P., et al. Differential functional avidity of dengue virus-specific T-cell clones for variant peptides representing heterologous and previously encountered serotypes. Journal of Virology 2007, 81(18):10081-10091.
26. Dong T., Moran E., Vinh Chau N., Simmons C., Luhn K., Peng Y., et al. High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection. PLoS ONE 2007, 2(12):e1192.
27. Mongkolsapaya J., Duangchinda T., Dejnirattisai W., Vasanawathana S., Avirutnan P., Jairungsri A., et al. T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?. Journal of Immunology 2006, 176(6):3821-3829.
28. Chau T.N., Quyen N.T., Thuy T.T., Tuan N.M., Hoang D.M., Dung N.T., et al. Dengue in Vietnamese infants-results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity. The Journal of Infectious Diseases 2008, 198(4):516-524.
29. Dung N.T., Duyen H.T., Thuy N.T., Ngoc T.V., Chau N.V., Hien T.T., et al. Timing of CD8+ T cell responses in relation to commencement of capillary leakage in children with dengue. Journal of Immunology 2010, 184(12):7281-7287. [Epub 2010/05/21].
30. Malavige G.N., Jeewandara C., Alles K.M., Salimi M., Gomes L., Kamaladasa A., Jayaratne S.D., Ogg G.S. Suppression of virus specific immune responses by IL-10 in acute dengue infection. PLoS Neglected Tropical Diseases 2013 September 5, 7(9):e2409.
31. Sun P., Garcia J., Comach G., Vahey M.T., Wang Z., Forshey B.M., et al. Sequential waves of gene expression in patients with clinically defined dengue illnesses reveal subtle disease phases and predict disease severity. PLoS Neglected Tropical Diseases 2013, 7(7):e2298. [Epub 2013/07/23].
32. Myint K.S., Endy T.P., Mongkolsirichaikul D., Manomuth C., Kalayanarooj S., Vaughn D.W., et al. Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis. The Journal of Infectious Diseases 2006, 194(5):600-607. [Epub 2006/08/10].
33. Mathew A., Kurane I., Green S., Vaughn D.W., Kalayanarooj S., Suntayakorn S., et al. Impaired T cell proliferation in acute dengue infection. Journal of Immunology 1999, 162(9):5609-5615. [Epub 1999/05/05].
34. Devignot S., Sapet C., Duong V., Bergon A., Rihet P., Ong S., et al. Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue. PLoS ONE 2010, 5(7):e11671. [Epub 2010/07/24].
35. Malavige G.N., Huang L.C., Salimi M., Gomes L., Jayaratne S.D., Ogg G.S. Cellular and cytokine correlates of severe dengue infection. PLoS ONE 2012, 7(11):e50387. [Epub 2012/12/05].
36. Rathakrishnan A., Wang S.M., Hu Y., Khan A.M., Ponnampalavanar S., Lum L.C., et al. Cytokine expression profile of dengue patients at different phases of illness. PLoS ONE 2012, 7(12):e52215. [Epub 2013/01/04].
37. Butthep P., Chunhakan S., Yoksan S., Tangnararatchakit K., Chuansumrit A. Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever. The Pediatric Infectious Disease Journal 2012, 31(12):e232-e238. [Epub 2012/08/29].
38. Malavige G.N., Gomes L., Alles L., Chang T., Salimi M., Fernando S., et al. Serum IL-10 as a marker of severe dengue infection. BMC Infectious Diseases 2013, 13(1):341. [Epub 2013/07/26].
39. Jayaratne S.D., Atukorale V., Gomes L., Chang T., Wijesinghe T., Fernando S., et al. Evaluation of the WHO revised criteria for classification of clinical disease severity in acute adult dengue infection. BMC Research Notes 2012, 5:645. [Epub 2012/11/22].
40. Guilarde A.O., Turchi M.D., Siqueira J.B., Feres V.C., Rocha B., Levi J.E., et al. Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response. The Journal of Infectious Diseases 2008, 197(6):817-824.
41. Wang W.K., Chen H.L., Yang C.F., Hsieh S.C., Juan C.C., Chang S.M., et al. Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. Clinical Infectious Diseases 2006, 43(8):1023-1030.
42. Brasier A.R., Ju H., Garcia J., Spratt H.M., Victor S.S., Forshey B.M., et al. A three-component biomarker panel for prediction of dengue hemorrhagic fever. The American Journal of Tropical Medicine and Hygiene 2012, 86(2):341-348. [Epub 2012/02/04].
43. Priyadarshini D., Gadia R.R., Tripathy A., Gurukumar K.R., Bhagat A., Patwardhan S., et al. Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study. PLoS ONE 2010, 5(1):e8709.
44. Chen L.C., Lei H.Y., Liu C.C., Shiesh S.C., Chen S.H., Liu H.S., et al. Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. The American Journal of Tropical Medicine and Hygiene 2006, 74(1):142-147.
45. Green S., Vaughn D.W., Kalayanarooj S., Nimmannitya S., Suntayakorn S., Nisalak A., et al. Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. Journal of Medical Virology 1999, 59(3):329-334.
46. Pinto L.M., Oliveira S.A., Braga E.L., Nogueira R.M., Kubelka C.F. Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Memorias do Instituto Oswaldo Cruz 1999, 94(3):387-394.
47. Bozza F.A., Cruz O.G., Zagne S.M., Azeredo E.L., Nogueira R.M., Assis E.F., et al. Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infectious Diseases 2008, 8:86.
48. Kumar Y., Liang C., Bo Z., Rajapakse J.C., Ooi E.E., Tannenbaum S.R. Serum proteome and cytokine analysis in a longitudinal cohort of adults with primary dengue infection reveals predictive markers of DHF. PLoS Neglected Tropical Diseases 2012, 6(11):e1887. [Epub 2012/12/05].
49. Palmer D.R., Sun P., Celluzzi C., Bisbing J., Pang S., Sun W., et al. Differential effects of dengue virus on infected and bystander dendritic cells. Journal of Virology 2005, 79(4):2432-2439.
50. Sun P., Bauza K., Pal S., Liang Z., Wu S.J., Beckett C., et al. Infection and activation of human peripheral blood monocytes by dengue viruses through the mechanism of antibody-dependent enhancement. Virology 2011, 421(2):245-252. [Epub 2011/10/29].
51. Cologna R., Rico-Hesse R. American genotype structures decrease dengue virus output from human monocytes and dendritic cells. Journal of Virology 2003, 77(7):3929-3938.
52. Durbin A.P., Vargas M.J., Wanionek K., Hammond S.N., Gordon A., Rocha C., et al. Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever. Virology 2008, 376(2):429-435.
53. Mangada M.M., Rothman A.L. Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes. Journal of Immunology 2005, 175(4):2676-2683.
54. Bashyam H.S., Green S., Rothman A.L. Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes. Journal of Immunology 2006, 176(5):2817-2824.
55. Mathew A., Kurane I., Green S., Stephens H.A., Vaughn D.W., Kalayanarooj S., et al. Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. Journal of Virology 1998, 72(5):3999-4004.
56. Wallace D., Canouet V., Garbes P., Wartel T.A. Challenges in the clinical development of a dengue vaccine. Current Opinion in Virology 2013, 3(3):352-356. [Epub 2013/06/12].
57. Coller B.A., Clements D.E. Dengue vaccines: progress and challenges. Current Opinion in Immunology 2011, 23(3):391-398. [Epub 2011/04/26].
58. Malavige G.N., McGowan S., Atukorale V., Salimi M., Peelawatta M., Fernando N., et al. Identification of serotype-specific T cell responses to highly conserved regions of the dengue viruses. Clinical and Experimental Immunology 2012, 168(2):215-223.
59. Anderson K.B., Gibbons R.V., Thomas S.J., Rothman A.L., Nisalak A., Berkelman R.L., et al. Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand. PLoS Neglected Tropical Diseases 2011, 5(10):e1311.