Cellular and Cytokine Correlates of Severe Dengue Infection

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Malavige, Gathsaurie Neelika ^a,b   Huang, Li Chieh ^b   Salimi, Maryam ^b   Gomes, Laksiri ^a   Jayaratne, S D ^a   Ogg, Graham S ^b,c  

^a UNIVERSITY OF SRI JAYEWARDENEPURA   (Sri Lanka)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 3; LIPOCORTIN 5; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RESPONSE; DENGUE; DENGUE VIRUS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSPOT ASSAY; EX VIVO STUDY; FEMALE; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHOCK; T LYMPHOCYTE; THROMBOCYTE RELEASE REACTION;

ADOLESCENT; ADULT; AGED; CHEMOKINES; COHORT STUDIES; CYTOKINES; DENGUE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-10; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; PEPTIDES; PROPIDIUM; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

DENGUE VIRUS;

EID: 84870556564     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050387     Document Type: Article

References (43)

1. Callaway E, (2007) Dengue fever climbs the social ladder. Nature 448: 734-735.
2. Malavige GN, Fernando S, Fernando DJ, Seneviratne SL, (2004) Dengue viral infections. Postgrad Med J 80: 588-601.
3. Ong A, Sandar M, Chen MI, Sin LY, (2007) Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. Int J Infect Dis 11: 263-267.
4. Mathew A, Rothman AL, (2008) Understanding the contribution of cellular immunity to dengue disease pathogenesis. Immunol Rev 225: 300-313.
5. Malavige GN, Velathanthiri VG, Wijewickrama ES, Fernando S, Jayaratne SD, et al. (2006) Patterns of disease among adults hospitalized with dengue infections. Qjm 99: 299-305.
6. Martina BE, Koraka P, Osterhaus AD, (2009) Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 22: 564-581.
7. Dong T, Moran E, Vinh Chau N, Simmons C, Luhn K, et al. (2007) High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection. PLoS One 2: e1192.
8. Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P, et al. (2006) T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? J Immunol 176: 3821-3829.
9. Jaiyen Y, Masrinoul P, Kalayanarooj S, Pulmanausahakul R, Ubol S, (2009) Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness. Microbiol Immunol 53: 442-450.
10. Mongkolsapaya J, Dejnirattisai W, Xu XN, Vasanawathana S, Tangthawornchaikul N, et al. (2003) Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 9: 921-927.
11. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, et al. (2000) Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181: 2-9.
12. Thomas L, Verlaeten O, Cabie A, Kaidomar S, Moravie V, et al. (2008) Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic. Am J Trop Med Hyg 78: 990-998.
13. Wang WK, Chao DY, Kao CL, Wu HC, Liu YC, et al. (2003) High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis. Virology 305: 330-338.
14. Guilarde AO, Turchi MD, Siqueira JB Jr, Feres VC, Rocha B, et al. (2008) Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response. J Infect Dis 197: 817-824.
15. Low JG, Ong A, Tan LK, Chaterji S, Chow A,et al. The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis 5: e1191.
16. WHO (2009) Dengue guildelines for diagnosis, prevention and control: World Health Organisation.
17. Mathew A, Kurane I, Green S, Stephens HA, Vaughn DW, et al. (1998) Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. J Virol 72: 3999-4004.
18. Beaumier CM, Mathew A, Bashyam HS, Rothman AL, (2008) Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner. J Infect Dis 197: 608-617.
19. Simmons CP, Dong T, Chau NV, Dung NT, Chau TN, et al. (2005) Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections. J Virol 79: 5665-5675.
20. Durbin AP, Vargas MJ, Wanionek K, Hammond SN, Gordon A, et al. (2008) Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever. Virology 376: 429-435.
21. Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, et al. (2006) Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg 74: 142-147.
22. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, et al. (1999) Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. J Med Virol 59: 329-334.
23. Pinto LM, Oliveira SA, Braga EL, Nogueira RM, Kubelka CF, (1999) Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Mem Inst Oswaldo Cruz 94: 387-394.
24. Bozza FA, Cruz OG, Zagne SM, Azeredo EL, Nogueira RM, et al. (2008) Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect Dis 8: 86.
25. Priyadarshini D, Gadia RR, Tripathy A, Gurukumar KR, Bhagat A, et al. (2010) Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study. PLoS One 5: e8709.
26. Vaughn DW, Nisalak A, Solomon T, Kalayanarooj S, Nguyen MD, et al. (1999) Rapid serologic diagnosis of dengue virus infection using a commercial capture ELISA that distinguishes primary and secondary infections. Am J Trop Med Hyg 60: 693-698.
27. Malavige GN, Rohanachandra LT, Jones L, Crack L, Perera M, et al. (2010) IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies. Br J Cancer 102: 727-730.
28. Macedo C, Webber SA, Donnenberg AD, Popescu I, Hua Y, et al. (2011) EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function. J Immunol 186: 5854-5862.
29. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C, (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51.
30. Appanna R, Huat TL, See LL, Tan PL, Vadivelu J, et al. (2007) Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia. Clin Vaccine Immunol 14: 969-977.
31. Chaturvedi UC, Elbishbishi EA, Agarwal R, Raghupathy R, Nagar R, et al. (1999) Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol 59: 335-340.
32. Mabalirajan U, Kadhiravan T, Sharma SK, Banga A, Ghosh B, (2005) Th(2) immune response in patients with dengue during defervescence: preliminary evidence. Am J Trop Med Hyg 72: 783-785.
33. Mustafa AS, Elbishbishi EA, Agarwal R, Chaturvedi UC, (2001) Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol 30: 229-233.
34. Chaturvedi UC, Agarwal R, Elbishbishi EA, Mustafa AS, (2000) Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28: 183-188.
35. Duangchinda T, Dejnirattisai W, Vasanawathana S, Limpitikul W, Tangthawornchaikul N, et al. (2011) Immunodominant T-cell responses to dengue virus NS3 are associated with DHF. Proc Natl Acad Sci U S A 107: 16922-16927.
36. Kou Z, Quinn M, Chen H, Rodrigo WW, Rose RC, et al. (2008) Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells. J Med Virol 80: 134-146.
37. Boonnak K, Dambach KM, Donofrio GC, Tassaneetrithep B, Marovich MA, (2011) Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection. J Virol 85: 1671-1683.
38. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, et al. (1999) Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis 180: 1429-1435.
39. Perez AB, Garcia G, Sierra B, Alvarez M, Vazquez S, et al. (2004) IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol 73: 230-234.
40. Hasegawa S, Matsushige T, Inoue H, Shirabe K, Fukano R, et al. (2011) Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy. Cytokine 54: 167-172.
41. Wang H, Xu J, Ji X, Yang X, Sun K, et al. (2005) The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus. Cell Immunol 235: 117-121.
42. Wang WK, Chen HL, Yang CF, Hsieh SC, Juan CC, et al. (2006) Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. Clin Infect Dis 43: 1023-1030.
43. Agarwal R, Elbishbishi EA, Chaturvedi UC, Nagar R, Mustafa AS, (1999) Profile of transforming growth factor-beta 1 in patients with dengue haemorrhagic fever. Int J Exp Pathol 80: 143-149.