Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes

Journal of Immunology

Volumn 175, Issue 4, 2005, Pages 2676-2683

  Mangada, Maloy M ^a,b   Rothman, Alan L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Acambis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DENGUE VACCINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN DETECTION; ARTICLE; CELL FUNCTION; CYTOKINE PRODUCTION; DENGUE; EFFECTOR CELL; HEMORRHAGIC FEVER; HUMAN; HUMAN EXPERIMENT; IMMUNOPATHOGENESIS; INFLAMMATION; LYMPHOCYTE COUNT; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SEROTYPE;

EID: 23444438390     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.4.2676     Document Type: Article

References (34)

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
2. + T lymphocytes. Nature 421: 852-856.
3. Shedlock, D. J., J. K. Whitmire, J. Tan, A. S. MacDonald, R. Ahmed, and H. Shen. 2003. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J. Immunol. 170: 2053-2063.
4. Brown, D. M., E. Roman, and S. L. Swain. 2004. CD4 T cell responses to influenza infection. Semin. Immunol. 16: 171-177.
5. Halstead, S. B., S. Nimmannitya, and S. N. Cohen. 1970. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J. Biol. Med. 42: 311-328.
6. Sangkawibha, N., S. Rojanasuphot, S. Ahandrik, S. Viriyapongse, S. Jatanasen, V. Salitul, B. Phanthumachinda, and S. B. Halstead. 1984. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am. J. Epidemiol. 120: 653-669.
7. Burke, D. S., A. Nisalak, D. E. Johnson, and R. M. Scott. 1988. A prospective study of dengue infections in Bangkok. Am. J. Trop. Med. Hyg. 38: 172-180.
8. Thein, S., M. M. Aung, T. N. Shwe, M. Aye, A. Zaw, K. Aye, K. M. Aye, and J. Aaskov. 1997. Risk factors in dengue shock syndrome. Am. J. Trop. Med. Hyg. 56: 566-572.
9. Kliks, S. 1990. Antibody-enhanced infection of monocytes as the pathogenetic mechanism for severe dengue illness. AIDS Res. Hum. Retroviruses 6: 993-998.
10. Kurane, I., A. Meager, and F. A. Ennis. 1989. Dengue virus-specific human T cell clones: serotype crossreactive proliferation, interferon γ production, and cytotoxic activity. J. Exp. Med. 170: 763-775.
11. Kurane, I., B. L. Innis, S. Nimmannitya, A. Nisalak, A. L. Rothman, P. G. Livingston, J. Janus, and F. A. Ennis. 1990. Human immune responses to dengue viruses. Southeast Asian J. Trop. Med. Public Health 21: 658-662.
12. + cytotoxic T-lymphocyte clones. J. Virol. 73: 3623-3629.
13. Mangada, M. M., T. P. Endy, A. Nisalak, S. Chunsuttiwat, D. W. Vaughn, D. H. Libraty, S. Green, F. A. Ennis, and A. L. Rothman. 2002. Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren. J. Infect. Dis. 185: 1697-1703.
14. McKee, K. T., Jr., W. H. Bancroft, K. H. Eckels, R. R. Redfield, P. L. Summers, and P. K. Russell. 1987. Lack of attenuation of a candidate dengue 1 vaccine (45AZ5) in human volunteers. Am. J. Trop. Med. Hyg. 36: 435-442.
15. Innis, B. L., K. H. Eckels, E. Kraiselburd, D. R. Dubois, G. F. Meadors, D. J. Gubler, D. S. Burke, and W. H. Bancroft. 1988. Virulence of a live dengue virus vaccine candidate: a possible new marker of dengue virus attenuation. J. Infect. Dis. 158: 876-880.
16. Hoke, C. H., Jr., F. J. Malinoski, K. H. Eckels, R. M. Scott, D. R. Dubois, P. L. Summers, T. Simms, J. Burrous, S. E. Hasty, and W. H. Bancroft. 1990. Preparation of an attenuated dengue 4 (341750 Carib) virus vaccine. II. Safety and immunogenicity in humans. Am. J. Trop. Med Hyg. 43: 219-226.
17. Dharakul, T., I. Kurane, N. Bhamarapravati, S. Yoksan, D. W. Vaughn, C. H. Hoke, and F. A. Ennis. 1994. Dengue virus-specific memory T cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine. J. Infect. Dis. 170: 27-33.
18. + cytotoxic T-lymphocyte clones. J. Virol. 70: 141-147.
19. + cytotoxic T lymphocytes of dengue virus nonstructural proteins NS3 and NS1.2a. J. Clin. Invest. 98: 1684-1691.
20. Kurane, I., B. L. Innis, A. Nisalak, C. Hoke, S. Nimmannitya, A. Meager, and F. A. Ennis. 1989. Human T cell responses to dengue virus antigens: proliferative responses and Interferon γ production. J. Clin. Invest. 83: 506-513.
21. - cytotoxic T lymphocyte clones. J. Gen. Virol. 76: 2243-2249.
22. Kurane, I., B. L. Innis, C. H. Hoke, Jr., K. H. Eckels, A. Meager, J. Janus, and F. A. Ennis. 1995. T cell activation in vivo by dengue virus infection. J. Clin. Lab. Immunol. 46: 35-40.
23. + cytotoxic T lymphocyte clones cross-reactive for dengue virus types 2, 3, and 4. Virology 240: 169-174.
24. - cytotoxic T-cell clone. J. Virol. 67: 6285-6288.
25. + T-cell clones. J. Virol. 70: 3108-3117.
26. + T cells by intracellular cytokine staining. J. Immunol. Methods 284: 89-97.
27. Sabin, A. B. 1952. Research on dengue during World War II. Am. J. Trop. Med. Hyg. 1: 30-50.
28. + T cell responses: correlation of cytokine profile and TCR avidity. J. Immunol. 172: 5553-5560.
29. De Rosa, S. C., F. X. Lu, J. Yu, S. P. Perfetto, J. Falloon, S. Moser, T. G. Evans, R. Koup, C. J. Miller, and M. Roederer. 2004. Vaccination in humans generates broad T cell cytokine responses. J. Immunol. 173: 5372-5380.
30. Selin, L. K., S. M. Varga, I. C. Wong, and R. M. Welsh. 1998. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J. Exp. Med. 188: 1705-1715.
31. Brehm, M. A., A. K. Pinto, K. A. Daniels, J. P. Schneck, R. M. Welsh, and L. K. Selin. 2002. T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat. Immunol. 3: 627-634.
32. Tracey, K. J., and A. Cerami. 1994. Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu. Rev. Med. 45: 491-503.
33. Bethell, D. B., K. Flobbe, X. T. Cao, N. P. Day, T. P. Pham, W. A. Buurman, M. J. Cardosa, N. J. White, and D. Kwiatkowski. 1998. Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. J. Infect. Dis. 177: 778-782.
34. Green, S., S. Pichyangkul, D. W. Vaughn, S. Kalayanarooj, S. Nimmannitya, A. Nisalak, I. Kurane, A. L. Rothman, and F. A. Ennis. 1999. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J. Infect. Dis. 180: 1429-1435.