Dose-dependent induction of preneoplastic lesions by the tobacco-specific nitrosamine carcinogen NNK in the in ovo carcinogenicity assessment (IOCA) assay

Experimental and Toxicologic Pathology

Volumn 66, Issue 1, 2014, Pages 35-40

  Enzmann, Harald G ^a   Brunnemann, Klaus D ^b   Kaestner, Bettina ^a   Iatropoulos, Michael J ^b   Williams, Gary M ^b  

^a FEDERAL INSTITUTE FOR DRUGS AND MEDICAL DEVICES   (Germany)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Avian; Cancer; Foci; Liver; NNK; Ovo; Preneoplasia; Tobacco

Indexed keywords

4 (N METHYL N NITROSAMINO) 1 (3 PYRIDYL) 1 1 BUTANONE; ADENOSINE TRIPHOSPHATASE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; NITROSAMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARCINOGEN TESTING; CELL DEATH; CELL ENLARGEMENT; CELL NUCLEUS; CELL SIZE; CELL STRUCTURE; DOSE RESPONSE; EGG; ENZYME ACTIVITY; FETUS; HEPATOCELLULAR ALTERED FOCI; HISTOCHEMISTRY; HISTOPATHOLOGY; IN OVO CARCINOGENICITY ASSESSMENT ASSAY; INCUBATION TIME; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; MORTALITY; NONHUMAN; ONCOLOGICAL PARAMETERS; PRECANCER;

ANIMALIA; AVES; MAMMALIA; NICOTIANA TABACUM; RODENTIA; SPONDIAS PURPUREA;

AVIAN; CANCER; FOCI; LIVER; NNK; OVO; PRENEOPLASIA; TOBACCO;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; NITROSAMINES; OVUM; PRECANCEROUS CONDITIONS; TOBACCO; TURKEYS;

EID: 84888817508     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.08.001     Document Type: Article

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