A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals

Toxicologic Pathology

Volumn 38, Issue 1, 2010, Pages 182-187

  Tsuda, Hiroyuki ^a   Futakuchi, Mitsuru ^a   Fukamachi, Katsumi ^a   Shirai, Tomoyuki ^a   Imaida, Katsumi ^b   Fukushima, Shoji ^c   Tatematsu, Masae ^c   Furukawa, Fumio ^d   Tamano, Seiko ^d   Ito, Nobuyuki ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c Japan Bioassay Research Center   (Japan)

^d Daiyukai Research Institute for Medical Science   (Japan)

Author keywords

Carcinogens; Liver GST P; Medium term bioassay; Multi organ

Indexed keywords

1,2 DIMETHYLHYDRAZINE; BIS(2 HYDROXYPROPYL)NITROSAMINE; CARCINOGEN; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOASSAY; CARCINOGENICITY; CONTROLLED STUDY; FALSE POSITIVE RESULT; GENOTOXICITY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MALE; MUTAGENICITY; NONHUMAN; PRECANCER; PRIORITY JOURNAL; RAT; REVIEW; RODENT; ANIMAL; ARTICLE; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; FISCHER 344 RAT; LIVER TUMOR; METHODOLOGY;

RATTUS; RODENTIA;

ANIMALS; CARCINOGENICITY TESTS; DISEASE MODELS, ANIMAL; GLUTATHIONE S-TRANSFERASE PI; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RATS; RATS, INBRED F344;

EID: 77952304108     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309356451     Document Type: Review

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