메뉴 건너뛰기




Volumn 26, Issue 2, 1996, Pages 121-137

Formation and analysis of tobacco-specific N-nitrosamines

Author keywords

(NNK); 4 (methyl nitrosamino) 1 (3 pyridyl) 1 butanone; Cigarette mainstream smoke (MS); Gas chromatography (GC); N' nitrosonornicotine (NNN); Sidestream smoke (SS); Snuff; Supercritical fluid extraction (SFE); Thermal energy analyzer (TEA); Tobacco specific N nitrosamines (TSNA)

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CIGARETTE SMOKE; NITROSAMINE; NITROSONORNICOTINE;

EID: 0029947343     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.3109/10408449609017926     Document Type: Review
Times cited : (85)

References (43)
  • 2
    • 0017803648 scopus 로고
    • Reaction of nicotine and sodium nitrite: Formation of nitrosamines and fragmentation of the pyrrolidine ring
    • Hecht, S. S., Chen, C.-H. B., Ornaf, R. M., Jacobs, E., Adams, J. D., and Hoffmann, D., Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring, J. Org. Chem., 43, 72, 1978.
    • (1978) J. Org. Chem. , vol.43 , pp. 72
    • Hecht, S.S.1    Chen, C.-H.B.2    Ornaf, R.M.3    Jacobs, E.4    Adams, J.D.5    Hoffmann, D.6
  • 4
    • 0000285368 scopus 로고
    • Nitrosative cleavage of tertiary amines
    • Smith, P. A. S. and Loeppky, R. N., Nitrosative cleavage of tertiary amines, J. Am. Chem. Soc., 89, 1147, 1967.
    • (1967) J. Am. Chem. Soc. , vol.89 , pp. 1147
    • Smith, P.A.S.1    Loeppky, R.N.2
  • 5
    • 0017693211 scopus 로고
    • Kinetics of nornicotine and anabasine nitrosation in relation to N′-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer
    • Mirvish, S. S., Sams, J., and Hecht, S. S., Kinetics of nornicotine and anabasine nitrosation in relation to N′-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer, J. Natl. Cancer Inst., 59, 1211, 1977.
    • (1977) J. Natl. Cancer Inst. , vol.59 , pp. 1211
    • Mirvish, S.S.1    Sams, J.2    Hecht, S.S.3
  • 6
    • 9244253038 scopus 로고
    • Influence of temperature and humidity on the accumulation of tobacco-specific nitrosamines in stored burley tobacco
    • Burton, H. R., Bush, L. P., and Djordjevic, M. V., Influence of temperature and humidity on the accumulation of tobacco-specific nitrosamines in stored burley tobacco, J. Agric. Food Chem., 37, 1725, 1989.
    • (1989) J. Agric. Food Chem. , vol.37 , pp. 1725
    • Burton, H.R.1    Bush, L.P.2    Djordjevic, M.V.3
  • 7
    • 0024448473 scopus 로고
    • Effect of storage conditions on nitrosated, aceylated, and oxidized pyridine alkaloid derivatives in smokeless tobacco products
    • Andersen, R. A., Burton, H. R., Fleming, P. D., and Hamilton-Kemp, T. R., Effect of storage conditions on nitrosated, aceylated, and oxidized pyridine alkaloid derivatives in smokeless tobacco products, Cancer Res., 49, 5895, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 5895
    • Andersen, R.A.1    Burton, H.R.2    Fleming, P.D.3    Hamilton-Kemp, T.R.4
  • 8
    • 0345609322 scopus 로고
    • Nitrosated, aceylated, and oxidized pyridine alkaloids and their derivatives in air- and flue-cured KY71 dark tobacco during prolonged storage; effects of temperature and moisture
    • Andersen, R. A., Fleming, P. D., Burton, H. R., Hamilton-Kemp, T. R., Hildebrand, D. T., and Sutton, T. G., Nitrosated, aceylated, and oxidized pyridine alkaloids and their derivatives in air- and flue-cured KY71 dark tobacco during prolonged storage; effects of temperature and moisture, Tobacco Sci., 34, 50, 1990.
    • (1990) Tobacco Sci. , vol.34 , pp. 50
    • Andersen, R.A.1    Fleming, P.D.2    Burton, H.R.3    Hamilton-Kemp, T.R.4    Hildebrand, D.T.5    Sutton, T.G.6
  • 9
    • 0141543538 scopus 로고
    • Nitrosated, aceylated and oxidized pyridine alkaloids during storage of smokeless tobacco: Effects of moisture, temperature and their interactions
    • Andersen, R. A., Fleming, P. D., Burton, H. R., Hamilton-Kemp, T. R., and Sutton, T. G., Nitrosated, aceylated and oxidized pyridine alkaloids during storage of smokeless tobacco: effects of moisture, temperature and their interactions, J. Agric. Food Chem., 39, 1280, 1991.
    • (1991) J. Agric. Food Chem. , vol.39 , pp. 1280
    • Andersen, R.A.1    Fleming, P.D.2    Burton, H.R.3    Hamilton-Kemp, T.R.4    Sutton, T.G.5
  • 10
    • 0001453241 scopus 로고
    • Effects of storage conditions on levels of tobacco-specific N-nitrosamines and N-nitrosamino acids in U.S. moist snuff
    • Djordjevic, M. V., Fan, J., Bush, L. P., Brunnemann, K. D., and Hoffmann, D., Effects of storage conditions on levels of tobacco-specific N-nitrosamines and N-nitrosamino acids in U.S. moist snuff, J. Agric. Food. Chem., 41, 1790, 1993.
    • (1993) J. Agric. Food. Chem. , vol.41 , pp. 1790
    • Djordjevic, M.V.1    Fan, J.2    Bush, L.P.3    Brunnemann, K.D.4    Hoffmann, D.5
  • 11
    • 0028971495 scopus 로고
    • Five leading U.S. commercial brands of moist snuff in 1994. Assessment of carcinogenic N-nitrosamines
    • Hoffmann, D., Djordjevic, M. V., Fan, J., Zang, E., Glynn, T., and Connolly, G. N., Five leading U.S. commercial brands of moist snuff in 1994. Assessment of carcinogenic N-nitrosamines, J. Natl. Cancer Inst., 87, 1862, 1995.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1862
    • Hoffmann, D.1    Djordjevic, M.V.2    Fan, J.3    Zang, E.4    Glynn, T.5    Connolly, G.N.6
  • 12
    • 0027319280 scopus 로고
    • The need for regulation of carcinogenic N-nitrosamines in oral snuff
    • Djordjevic, M. V., Brunnemann, K. D., and Hoffmann, D., The need for regulation of carcinogenic N-nitrosamines in oral snuff. Food Chem. Toxicol., 31, 497, 1993.
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 497
    • Djordjevic, M.V.1    Brunnemann, K.D.2    Hoffmann, D.3
  • 14
    • 0026582799 scopus 로고
    • Bioavalability of tobacco-specific N-nitrosamines to the snuff dipper
    • Prokopczyk, B., Wu, M., Cox, J. E., and Hoffmann, D., Bioavalability of tobacco-specific N-nitrosamines to the snuff dipper, Carcinogenesis, 13, 863, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 863
    • Prokopczyk, B.1    Wu, M.2    Cox, J.E.3    Hoffmann, D.4
  • 15
    • 0026775447 scopus 로고
    • Supercritical fluid extraction in the determination of tobacco-specific N-nitrosamines in smokeless tobacco
    • Prokopczyk, B., Hoffmann, D., Cox, J. E., Djordjevic, M. V., and Brunnemann, K. D., Supercritical fluid extraction in the determination of tobacco-specific N-nitrosamines in smokeless tobacco, Chem. Res. Toxicol., 5, 336, 1992.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 336
    • Prokopczyk, B.1    Hoffmann, D.2    Cox, J.E.3    Djordjevic, M.V.4    Brunnemann, K.D.5
  • 16
    • 0001466176 scopus 로고
    • Improved methodology for the quantitative assessment of tobacco-specific N-nitrosamines in tobacco by supercritical fluid extraction
    • Prokopczyk, B., Wu, M., Cox, J. E., Amin, S., Desai, D., Idris, A. M., and Hoffmann, D., Improved methodology for the quantitative assessment of tobacco-specific N-nitrosamines in tobacco by supercritical fluid extraction. J. Agric. Food Chem., 43, 916, 1995.
    • (1995) J. Agric. Food Chem. , vol.43 , pp. 916
    • Prokopczyk, B.1    Wu, M.2    Cox, J.E.3    Amin, S.4    Desai, D.5    Idris, A.M.6    Hoffmann, D.7
  • 17
    • 0028104721 scopus 로고
    • Toombak: A major risk factor for cancer of the oral cavity in Sudan
    • Idris, A. M., Prokopczyk, B., and Hoffmann, D., Toombak: a major risk factor for cancer of the oral cavity in Sudan, Prev. Med., 23, 832, 1994.
    • (1994) Prev. Med. , vol.23 , pp. 832
    • Idris, A.M.1    Prokopczyk, B.2    Hoffmann, D.3
  • 19
    • 0025851284 scopus 로고
    • Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?
    • Shopland, D. R., Eyre, H.-J., and Pechacek, T. F., Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?, J. Natl. Cancer Inst., 83, 1142, 1991.
    • (1991) J. Natl. Cancer Inst. , vol.83 , pp. 1142
    • Shopland, D.R.1    Eyre, H.-J.2    Pechacek, T.F.3
  • 21
  • 22
    • 0028177696 scopus 로고
    • Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity and relevance to humans
    • Hoffmann, D., Brunnemann, K. D., Prokopczyk, B., and Djordjevic, M. V., Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity and relevance to humans, J. Toxicol. Environ. Health, 41, 1, 1994.
    • (1994) J. Toxicol. Environ. Health , vol.41 , pp. 1
    • Hoffmann, D.1    Brunnemann, K.D.2    Prokopczyk, B.3    Djordjevic, M.V.4
  • 23
    • 0026770463 scopus 로고
    • Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan
    • Idris, A. M., Nair, J., Ohshima, H., Friesen, M., Brouet, I., Faustman, E. M., and Bartsch, H., Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan, Carcinogenesis, 13, 1001, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 1001
    • Idris, A.M.1    Nair, J.2    Ohshima, H.3    Friesen, M.4    Brouet, I.5    Faustman, E.M.6    Bartsch, H.7
  • 24
    • 0028216574 scopus 로고
    • Uptake and metabolism of carcinogenic levels of tobacco-specific nitrosamines by Sudanese snuff dippers, Cancer Epidemiol
    • Murphy, S. E., Carmella, S. G., Idris, A. M., and Hoffmann, D., Uptake and metabolism of carcinogenic levels of tobacco-specific nitrosamines by Sudanese snuff dippers, Cancer Epidemiol. Biomarkers Prev., 3, 423, 1994.
    • (1994) Biomarkers Prev. , vol.3 , pp. 423
    • Murphy, S.E.1    Carmella, S.G.2    Idris, A.M.3    Hoffmann, D.4
  • 25
    • 9244222549 scopus 로고
    • Artifact formation during trapping. An improved method for the determination of N-nitrosamines in cigarette smoke
    • Richmond, Virginia, Abstr. 45
    • Caldwell, W. S. and Conner, J. M., Artifact formation during trapping. An improved method for the determination of N-nitrosamines in cigarette smoke, in 43rd Tobacco Chem. Res. Conf., Richmond, Virginia, Abstr. 45, 1989.
    • (1989) 43rd Tobacco Chem. Res. Conf.
    • Caldwell, W.S.1    Conner, J.M.2
  • 26
    • 0009753603 scopus 로고
    • Formation of 4-(methylnitrosamino)-4-(3-pyridyl)butyric acid in vitro and in mainstream cigarette smoke
    • Djordjevic, M. V., Sigountos, C. W., Brunnemann, K. D., and Hoffmann, D., Formation of 4-(methylnitrosamino)-4-(3-pyridyl)butyric acid in vitro and in mainstream cigarette smoke, J. Agric. Food Chem., 39, 209, 1991.
    • (1991) J. Agric. Food Chem. , vol.39 , pp. 209
    • Djordjevic, M.V.1    Sigountos, C.W.2    Brunnemann, K.D.3    Hoffmann, D.4
  • 28
    • 9244250713 scopus 로고
    • Tobacco-specific nitrosamine delivery in mainstream smoke of high- and low-yield cigarettes smoked with varying puff volume
    • Kallithea, Greece
    • Djordjevic, M. V., Sigountos, C. W., Brunnemann, K. D., and Hoffmann, D., Tobacco-specific nitrosamine delivery in mainstream smoke of high- and low-yield cigarettes smoked with varying puff volume, in Proc. CORESTA Symp., Kallithea, Greece, 1990, 54-62.
    • (1990) Proc. CORESTA Symp. , pp. 54-62
    • Djordjevic, M.V.1    Sigountos, C.W.2    Brunnemann, K.D.3    Hoffmann, D.4
  • 29
    • 0023224629 scopus 로고
    • Toxic and carcinogenic agents in undiluted mainstream and sidestream smoke of different types of cigarettes
    • Adams, J. D., O'Mara-Adams, K. J., and Hoffmann, D., Toxic and carcinogenic agents in undiluted mainstream and sidestream smoke of different types of cigarettes, Carcinogenesis, 8, 729, 1987.
    • (1987) Carcinogenesis , vol.8 , pp. 729
    • Adams, J.D.1    O'Mara-Adams, K.J.2    Hoffmann, D.3
  • 30
    • 0003448477 scopus 로고
    • Nicotine Addiction, DHHS (CDC)86-8406, Rockville, MD
    • U.S. Surgeon General, The Health Consequences of Smoking. Nicotine Addiction, DHHS (CDC)86-8406, Rockville, MD, 1988.
    • (1988) The Health Consequences of Smoking
  • 31
    • 0028232207 scopus 로고
    • Establishing a nicotine threshold for addiction
    • Benowitz, N. L. and Henningfield, J. E., Establishing a nicotine threshold for addiction, N. Engl. J. Med., 331, 123, 1994.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 123
    • Benowitz, N.L.1    Henningfield, J.E.2
  • 32
    • 0024347531 scopus 로고
    • Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke. A contribution to relative risk evaluation
    • Fischer, S., Spiegelhalder, B., and Preussmann, R., Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke. A contribution to relative risk evaluation, Carcinogenesis, 10, 1059, 1989.
    • (1989) Carcinogenesis , vol.10 , pp. 1059
    • Fischer, S.1    Spiegelhalder, B.2    Preussmann, R.3
  • 34
    • 0027988016 scopus 로고
    • Smoking and lung cancer: Scientific challenges and opportunities
    • Wynder, E.L. and Hoffmann, D., Smoking and lung cancer: scientific challenges and opportunities. Cancer Res., 54, 5284, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5284
    • Wynder, E.L.1    Hoffmann, D.2
  • 37
    • 0027077977 scopus 로고
    • Analysis of tobacco-specific N-nitrosamines in indoor air
    • Brunnemann, K. D., Cox, J. E., and Hoffmann, D., Analysis of tobacco-specific N-nitrosamines in indoor air, Carcinogenesis, 13, 2415, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 2415
    • Brunnemann, K.D.1    Cox, J.E.2    Hoffmann, D.3
  • 41
    • 0019782616 scopus 로고
    • Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers
    • Hoffmann, D. and Adams, J. D., Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers, Cancer Res., 41, 4305, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 4305
    • Hoffmann, D.1    Adams, J.D.2
  • 43
    • 0023786216 scopus 로고
    • Tobacco-specific N-nitrosamines in the saliva of habitual male snuff dippers
    • Österdahl, B.-G. and Slorach, S., Tobacco-specific N-nitrosamines in the saliva of habitual male snuff dippers, Food Addit. Contam., 5, 581, 1988.
    • (1988) Food Addit. Contam. , vol.5 , pp. 581
    • Österdahl, B.-G.1    Slorach, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.