The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities

Molecular Biotechnology

Volumn 36, Issue 2, 2007, Pages 166-174

  Troy, Tammy Claire ^a   Turksen, Kursad ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Claudins (Cldns); Differentiation; Epidermis; Tight junctions (TJs)

Indexed keywords

CELLS; GENE EXPRESSION; MICROORGANISMS; RATS;

CLAUDINS (CLDNS); EPIDERMIS; TIGHT JUNCTIONS (TJ);

GENETIC ENGINEERING;

CLAUDIN; FILAGGRIN; INVOLUCRIN; KERATIN; LORICRIN; BIOLOGICAL MARKER; CLAUDIN 6; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; EPIDERMIS CELL; HAIR FOLLICLE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; CONGENITAL MALFORMATION; CYTOLOGY; GENETICS; METABOLISM; UPREGULATION;

MUS MUSCULUS;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; EPIDERMIS; HAIR FOLLICLE; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; UP-REGULATION;

EID: 35848967562     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-007-0027-z     Document Type: Article

References (41)

1. Shin, K., Fogg, V. C., & Margolis, B. (2006). Tight junctions and cell polarity. Annual Review of Cell and Developmental Biology, 22, 207-235.
2. Fleming, T. P., Ghassemifar, M. R., & Sheth, B. (2000). Junctional complexes in the early mammalian embryo. Seminars in Reproductive Medicine, 18, 185-193.
3. Perez-Moreno, M., & Fuchs, E. (2006). Catenins: Keeping cells from getting their signals crossed. Developmental Cell, 11, 601-612.
4. Itoh, M., & Bissell, M. J. (2003). The organization of tight junctions in epithelia: Implications for mammary gland biology and breast tumorigenesis. Journal of Mammary Gland Biology and Neoplasia, 8, 449-462.
5. Kolega, J. (1986). The cellular basis of epithelial morphogenesis. Developmental Cell, (N Y 1985) 2, 103-143.
6. Aijaz, S., Balda, M. S., & Matter, K. (2006). Tight junctions: Molecular architecture and function. International Review of Cytology, 248, 261-298.
7. Landau, D. (2006). Epithelial paracellular proteins in health and disease. Current Opinion in Nephrology and Hypertension, 15, 425-429.
8. Furuse, M., & Tsukita, S. (2006). Claudins in occluding junctions of humans and flies. Trends in Cell Biology, 16, 181-188.
9. Van Itallie, C. M., & Anderson, J. M. (2006). Claudins and epithelial paracellular transport. Annual Review of Physiology, 68, 403-429.
10. Mitic, L. L., & Anderson, J. M. (1998). Molecular architecture of tight junctions. Annual Review of Physiology, 60, 121-142.
11. Tsukita, S., Furuse, M., & Itoh, M. (2001). Multifunctional strands in tight junctions. Nature Reviews. Molecular Cell Biology, 2, 285-293.
12. Lapierre, L. A. (2000). The molecular structure of the tight junction. Advanced Drug Delivery Reviews, 41, 255-264.
13. Gonzalez-Mariscal, L., Betanzos, A., Nava, P., & Jaramillo, B. E. (2003). Tight junction proteins. Progress in Biophysics and Molecular Biology, 81, 1-44.
14. Tsukita, S., & Furuse, M. (1999). Occludin and claudins in tight-junction strands: leading or supporting players? Trends in Cell Biology, 9, 268-273.
15. Matter, K., Aijaz, S., Tsapara, A., & Balda, M. S. (2005). Mammalian tight junctions in the regulation of epithelial differentiation and proliferation. Current Opinion in Cell Biology, 17, 453-458.
16. Kohler, K., & Zahraoui, A. (2005). Tight junction: A co-ordinator of cell signalling and membrane trafficking. Biology of the Cell, 97, 659-665.
17. Turksen, K., & Troy, T. C. (2004). Barriers built on claudins. Journal of Cell Science, 117, 2435-2447.
18. Balkovetz, D. F. (2006). Claudins at the gate: Determinants of renal epithelial tight junction paracellular permeability. American Journal of Physiology Renal Physiology, 290, F572-F579.
19. Turksen, K., & Troy, T. C. (2002). Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development, 129, 1775-1784.
20. Tsukita, S., & Furuse, M. (2002). Claudin-based barrier in simple and stratified cellular sheets. Current Opinion in Cell Biology, 14, 531-536.
21. Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002). Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice. The Journal of Cell Biology, 156, 1099-1111.
22. Troy, T. C., Rahbar, R., Arabzadeh, A., Cheung, R. M., & Turksen, K. (2005). Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice. Mechanisms of Development, 122, 805-819.
23. Arabzadeh, A., Troy, T. C., & Turksen, K. (2006). Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo. Molecular and Cellular Biology, 26, 5876-5887.
24. Carroll, J. M., Albers, K. M., Garlick, J. A., Harrington, R., & Taichman, L. B. (1993). Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 90, 10270-10274.
25. Carroll, J. M., Romero, M. R., & Watt, F. M. (1995). Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell, 83, 957-968.
26. Hohl, D., Mehrel, T., Lichti, U., Turner, M. L., Roop, D. R., & Steinert, P. M. (1991). Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. The Journal of Biological Chemistry, 266, 6626-6636.
27. Turksen, K., Opas, M., Aubin, J. E., & Kalnins, V. I. (1983). Microtubules, microfilaments and adhesion patterns in differentiating chick retinal pigment epithelial (RPE). cells in vitro. Experimental Cell Research, 147, 379-391.
28. Elias, P. M. (2005). Stratum corneum defensive functions: An integrated view. The Journal of Investigative Dermatology, 125, 183-200.
29. Turksen, K., & Troy, T. C. (2001). Claudin-6: A novel tight junction molecule is developmentally regulated in mouse embryonic epithelium. Developmental Dynamics, 222, 292-300.
30. Whitbread, L. A., & Powell, B. C. (1998). Expression of the intermediate filament keratin gene, K15, in the basal cell layers of epithelia and the hair follicle. Experimental Cell Research, 244, 448-459.
31. Lloyd, C., Yu, Q. C., Cheng, J., Turksen, K., Degenstein, L., Hutton, E., & Fuchs, E. (1995). The basal keratin network of stratified squamous epithelia: Defining K15 function in the absence of K14. The Journal of Cell Biology, 129, 1329-1344.
32. Roop, D. R., Cheng, C. K., Titterington, L., Meyers, C. A., Stanley, J. R., Steinert, P. M., & Yuspa, S. H. (1984). Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. The Journal of Biological Chemistry, 259, 8037-8040.
33. Roop, D. R., Hawley-Nelson, P., Cheng, C. K., & Yuspa, S. H. (1983). Keratin gene expression in mouse epidermis and cultured epidermal cells. Proceedings of the National Academy of Sciences of the United States of America, 80, 716-720.
34. Fuchs, E., & Green, H. (1980). Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell, 19, 1033-1042.
35. Fuchs, E., & Green, H. (1978). The expression of keratin genes in epidermis and cultured epidermal cells. Cell, 15, 887-897.
36. Kopan, R., & Fuchs, E. (1989). The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells. Journal of Cell Biology, 109, 295-307.
37. McGowan, K., & Coulombe, P. A. (1998). The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. Sub-cellular Biochemistry, 31, 173-204.
38. Coulombe, P. A., Tong, X., Mazzalupo, S., Wang, Z., & Wong, P. (2004). Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo. European Journal of Cell Biology, 83, 735-746.
39. Mack, J. A., Anand, S., & Maytin, E. V. (2005). Proliferation and cornification during development of the mammalian epidermis. Birth Defects Research Part C, Embryo Today, 75, 314-329.
40. Lefort, K., & Dotto, G. P. (2004). Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Seminars in Cancer Biology, 14, 374-386.
41. Pan, Y., Lin, M. H., Tian, X., Cheng, H. T., Gridley, T., Shen, J., & Kopan, R. (2004). Gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Developmental Cell, 7, 731-743.