Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma)

Aquatic Toxicology

Volumn 146, Issue , 2014, Pages 115-126

  Ye, Ting ^a   Kang, Mei ^a   Huang, Qiansheng ^a   Fang, Chao ^a   Chen, Yajie ^a   Shen, Heqing ^a   Dong, Sijun ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

DEHP; Endocrine disruption; Hypothalamic pituitary gonad (HPG) axis; MEHP; Oryzias melastigma

Indexed keywords

ESTRADIOL; FOLLITROPIN BETA SUBUNIT; LOW DENSITY LIPOPROTEIN RECEPTOR; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; STEROID RECEPTOR; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; VITELLOGENIN;

BIOACCUMULATION; DOSE-RESPONSE RELATIONSHIP; EGG PRODUCTION; ENDOCRINE DISRUPTOR; FISH; GENE EXPRESSION; MOLECULAR ANALYSIS; ORGANIC COMPOUND; POLLUTION EFFECT; POLLUTION EXPOSURE; REPRODUCTION; SPAWNING; TOXICITY;

17BHSD GENE; ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYP17A1 GENE; CYP19A GENE; CYP19B GENE; EGG PRODUCTION; EMBRYO; ENDOCRINE DISEASE; ENVIRONMENTAL EXPOSURE; ESTRADIOL BLOOD LEVEL; FEMALE; FERTILIZATION; FSHB GENE; GENE; GENE EXPRESSION; GNRHR2 GENE; HATCHING; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LARVA; LDLR GENE; LONG TERM EXPOSURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; ORYZIAS; ORYZIAS MELASTIGMA; OVARY; OVARY FOLLICLE ATRESIA; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SEX DIFFERENCE; SPAWNING; SPERMATOZOON COUNT; STAR GENE; TESTIS; TESTOSTERONE BLOOD LEVEL; TRANSCRIPTION REGULATION; UPREGULATION;

ORYZIAS MELASTIGMA; ORYZIINAE;

17Β-ESTRADIOL; ANDROGEN RECEPTOR Α; ARΑ; BRAIN SOMATIC INDEX; BSI; CONDITION FACTOR; CYP11B; CYP17A1; CYP19; CYP21A; CYP3A; CYP450 21-Α-HYDROXYLASE; CYTOCHROME P450 11B; CYTOCHROME P450 17Α-HYDROXYLASE 1; CYTOCHROME P450 19; CYTOCHROME P450 3A; DEHP; DI-(2-ETHYLHEXYL)-PHTHALATE; DIMETHYL SULFOXIDE; DMSO; E2; ENDOCRINE DISRUPTION; ER; ESTROGEN RECEPTOR; FOLLICLE-STIMULATING HORMONE; FSH; GHR; GLUCOCORTICOID RECEPTOR; GNRHR2; GONADAL SOMATIC INDEX; GONADOTROPIN-RELEASING HORMONE RECEPTOR 2; GR; GROWTH HORMONE RECEPTOR; GSI; HPG; HSD; HYDROXYSTEROID DEHYDROGENASE; HYPOTHALAMIC-PITUITARY-GONAD; HYPOTHALAMIC-PITUITARY-GONAD (HPG) AXIS; IGF1R; INSULIN-LIKE GROWTH-FACTOR-1 RECEPTOR; K; LDLR; LOW DENSITY LIPOPROTEIN RECEPTOR; MEHHP; MEHP; MEOHP; MONO-(2-ETHYL-5-HYDROXYHEXYL)-PHTHALATE; MONO-(2-ETHYL-5-OXOHEXYL)-PHTHALATE; MONO-(2-ETHYLHEXYL)-PHTHALATE; NR5A2; NUCLEAR RECEPTOR SUBFAMILY-5 GROUP A MEMBER 2; ORYZIAS MELASTIGMA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PPAR; QRT-PCR; REAL-TIME QUANTITATIVE REVERSE TRANSCRIPTASE POLYMERASE CHAINREACTION; STAR; STEROIDOGENIC ACUTE REGULATORY PROTEIN; T; TESTOSTERONE; VITELLOGENIN; VTG;

ANIMALS; BRAIN; DIETHYLHEXYL PHTHALATE; ENDOCRINE SYSTEM; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; GONADS; LIVER; MALE; ORYZIAS; REPRODUCTION; VITELLOGENINS; WATER POLLUTANTS, CHEMICAL;

EID: 84888774739     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.10.025     Document Type: Article

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