Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes

Medical Hypotheses

Volumn 81, Issue 6, 2013, Pages 1031-1033

  Ritter, Philipp S ^a   Kretschmer, Karsten ^b   Pfennig, Andrea ^a   Soltmann, Bettina ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERLEUKIN 6; MESSENGER RNA; TOCILIZUMAB;

ARTICLE; BIPOLAR DISORDER; CODING; EVALUATION; HUMAN; MONOCYTE; PERIPHERAL MONOCYTE; PREDICTION; RHEUMATOID ARTHRITIS; SLEEP; SLEEP DISORDER; SLEEP QUALITY;

CENTRAL NERVOUS SYSTEM; CNS; IFN; IL; INTERFERON; INTERLEUKIN; NON-RAPID EYE MOVEMENT SLEEP; NREM; RAPID EYE MOVEMENT SLEEP; REM; TGF; TNF; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR;

ANIMALS; BIPOLAR DISORDER; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-6; MODELS, BIOLOGICAL; MONOCYTES; RNA, MESSENGER; SLEEP DISORDERS;

EID: 84888440208     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.09.025     Document Type: Article

References (45)

1. Harvey A.G., Schmidt D.A., Scarna A., Semler C.N., Goodwin G.M. Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems. Am J Psychiatry 2005, 162(1):50-57.
2. Ritter P., Marx C., Lewtschenko N., Pfeiffer S., Leopold K., Bauer M., et al. The characteristics of sleep in patients with manifest bipolar disorder, subjects at high risk of developing the disease and healthy controls. J Neural Transm 2012, 119(10):1173-1184.
3. Jones S.H., Hare D.J., Evershed K. Actigraphic assessment of circadian activity and sleep patterns in bipolar disorder. Bipolar Disord 2005, 7(2):176-186.
4. Millar A., Espie C.A., Scott J. The sleep of remitted bipolar outpatients: a controlled naturalistic study using actigraphy. J Affect Disord 2004, 80(2-3):145-153.
5. Mullin B.C., Harvey A.G., Hinshaw S.P. A preliminary study of sleep in adolescents with bipolar disorder, ADHD, and non-patient controls. Bipolar Disord 2011, 13(4):425-432.
6. Harvey A.G. Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 2008, 165(7):820-829.
7. Jackson A., Cavanagh J., Scott J. A systematic review of manic and depressive prodromes. J Affect Disord 2003, 74(3):209-217.
8. Colombo C., Benedetti F., Barbini B., Campori E., Smeraldi E. Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression. Psychiatry Res 1999, 86(3):267-270.
9. Baglioni C., Battagliese G., Feige B., Spiegelhalder K., Nissen C., Voderholzer U., et al. Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 2011, 13(1-3):10-19.
10. Ritter P.S., Marx C., Bauer M., Lepold K., Pfennig A. The role of disturbed sleep in the early recognition of bipolar disorder: a systematic review. Bipolar Disord 2011, 13(3):227-237.
11. Walker M.P. The role of sleep in cognition and emotion. Ann N Y Acad Sci 2009, 1156:168-197.
12. Walker M.P., van der Helm E. Overnight therapy? The role of sleep in emotional brain processing. Psychol Bull 2009, 135(5):731-748.
13. Harvey A.G. Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 2008, 165(7):820-829.
14. Harvey A.G., Murray G., Chandler R.A., Soehner A. Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms. Transdiagnostic and Transtheoretical Approaches. Clinical. Psychol Rev 2011, 31(2):225-235.
15. Milhiet V., Etain B., Boudebesse C., Bellivier F. Circadian biomarkers, circadian genes and bipolar disorders. J Physiol-Paris 2011, 105(4ΓÇÔ6):183-189.
16. Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006, 27(1):24-31.
17. Wirz-Justice A. Biological rhythm disturbances in mood disorders. Int Clin Psychopharmacol 2006, 21.
18. Drexhage R.C., Hoogenboezem T.H., Versnel M.A., Berghout A., Nolen W.A., Drexhage H.A. The activation of monocyte and T cell networks in patients with bipolar disorder. Brain Behav Immun 2011, 25(6):1206-1213.
19. Smith R.S. The macrophage theory of depression. Med Hypotheses 1991, 35(4):298-306.
20. D'Mello C., Le T., Swain M.G. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor signaling during peripheral organ inflammation. J Neurosci 2009, 29(7):2089-2102.
21. Konsman J.P., Luheshi G.N., Bluth R.M., Dantzer R. The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur J Neurosci 2000, 12(12):4434-4446.
22. Quan N., Banks W.A. Brain-immune communication pathways. Brain Behav Immun 2007, 21(6):727-735.
23. Spooren A., Kolmus K., Laureys G., Clinckers R., De Keyser J., Haegeman G., et al. Interleukin-6 a mental cytokine. Brain Res Rev 2011, 67(1ΓÇÔ2):157-183.
24. Drexhage R.C., Knijff E.M., Padmos R.C., Heul-Nieuwenhuijzen L.V.D., Beumer W., Versnel M.A., et al. The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Expert Rev Neurother 2009, 10(1):59-76.
25. Saijo K., Glass C.K. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 2011, 11(11):775-787.
26. Leboyer M., Soreca I., Scott J., Frye M., Henry C., Tamouza R., et al. Can bipolar disorder be viewed as a multi-system inflammatory disease?. J Affect Disord 2012, 141(1):1-10.
27. Ortiz-Dominguez A., Hern+índez M.A.E., Berlanga C., Gutierrez-Mora D., Moreno J., et al. Immune variations in bipolar disorder: phasic differences. Bipolar Disord 2007, 9(6):596-602.
28. Kim Y.K., Jung H.G., Myint A.M., Kim H., Park S.H. Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder. J Affect Disord 2007, 104(1-3):91-95.
29. Hope S., Dieset I., Agartz I., Steen N.E., Ueland T., Melle I., et al. Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatr Res 2011, 45(12):1608-1616.
30. Padmos R.C., Hillegers M.H.J., Knijff E.M., Vonk R., Bouvy A., Staal F.J.T., et al. A discriminating messenger rna signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 2008, 65(4):395-407.
31. Drexhage R.C., van der Heul-Nieuwenhuijsen L., Padmos R.C., van Beveren N., Cohen D., Versnel M.A., et al. Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients. Int J Neuropsychopharmacol 2010, 13(10):1369-1381.
32. Garver D.L., Tamas R.L., Holcomb J.A. Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype. Neuropsychopharmacology 2003, 28(8):1515-1520.
33. Opp M.R. Cytokines and sleep. Sleep Med Rev 2005, 9(5):355-364.
34. Obal F., Krueger J.M. Biochemical regulation of non-rapid-eye-movement sleep. Front Biosci 2003, 8:d520-d550.
35. Takahashi S., Kap+ís L., Seyer J.M., Wang Y., Krueger J.M. Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits. Neuroreport 1996, 7(2):642-646.
36. Imeri L., Opp M.R. How (and why) the immune system makes us sleep. Nat Rev Neurosci 2009, 10(3):199-210.
37. Thomas K.S., Motivala S., Olmstead R., Irwin M.R. Sleep depth and fatigue: role of cellular inflammatory activation. Brain Behav Immun 2011, 25(1):53-58.
38. Irwin M., Rinetti G., Redwine L., Motivala S., Dang J., Ehlers C. Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics. Brain Behav Immun 2004, 18(4):349-360.
39. Raison C.L., Borisov A.S., Majer M., Drake D.F., Pagnoni G., Woolwine B.J., et al. Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Psychiatry 2009, 65(4):296-303.
40. Raison C.L., Rye D.B., Woolwine B.J., Vogt G.J., Bautista B.M., Spivey J.R., et al. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 2010, 68(10):942-949.
41. Prather A.A., Rabinovitz M., Pollock B.G., Lotrich F.E. Cytokine-induced depression during IFN-g treatment: the role of IL-6 and sleep quality. Brain Behav Immun 2009, 23(8):1109-1116.
42. Fragiadaki K.A.L.L., Tektonidou M.G., Konsta M.A.R.I., Chrousos G.P., Sfikakis P.P. Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis. J Rheumatol 2012, 39(1):60-62.
43. Brietzke E., Scheinberg M., Lafer B. Therapeutic potential of interleukin-6 antagonism in bipolar disorder. Med Hypotheses 2011, 76(1):21-23.
44. Bauer M., Grof P., Rasgon N., Bschor T., Glenn T., Whybrow P.C. Temporal relation between sleep and mood in patients with bipolar disorder. Bipolar Disord 2006, 8(2):160-167.
45. Gruber J., Miklowitz D.J., Harvey A.G., Frank E., Kupfer D., Thase M.E., et al. Sleep matters: sleep functioning and course of illness in bipolar disorder. J Affect Disord 2011, 134:416-420.