Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 24, 2013, Pages 7830-7840

  Tiruveedhula, V V N Phani Babu ^a   Witzigmann, Christopher M ^a   Verma, Ranjit ^a   Kabir, M Shahjahan ^a   Rott, Marc ^b   Schwan, William R ^b   Medina Bielski, Sara ^b   Lane, Michelle ^b   Close, William ^b   Polanowski, Rebecca L ^b   Sherman, David ^c   Monte, Aaron ^b   Deschamps, Jeffrey R ^d   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b UNIVERSITY OF WISCONSIN LA CROSSE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Acrylic esters; Anti tuberculosis; Michael acceptor; Mycobacterium smegmatis; Mycobacterium tuberculosis

Indexed keywords

1,2 ETHYL 2 [4 (TERTBUTYL)BENZOYL]CYCLOPROPANECARBOXYLATE; 2,3 ETHYL 3 [4 (TERTBUTYL)BENZOYL]OXIRANE 2 CARBOXYLATE; 3 (4 TERT BUTYL PHENYLSULFANYL) PROPIONIC ACID ETHYL ESTER; 3 (BENZO[D]THIAZOL 2 YLTHIO) N,N DIISOPROPYLACRYLAMIDE; 3 (BENZO[D]THIAZOL 2 YLTHIO)ACRYLIC ACID; 3 [[4 (TERT BUTYL)PHENYL]THIO] N CYCLOPROPYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO] N METHYL N PHENYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO] N METHYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO] N PHENYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO] N,N DIISOPROPYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO] N,N DIMETHYLACRYLAMIDE; 3 [[4 (TERT BUTYL)PHENYL]THIO]ACRYLIC ACID; 3 METHYLBUT 2 EN 1 YL 4 [4 (TERT BUTYL)PHENYL] 4 OXOBUT 2 ENOATE; 4 [4 (TERT BUTYL)PHENYL] 4 OXOBUT 2 ENOIC ACID; ANTIINFECTIVE AGENT; CYCLOPROPYLMETHYL 3 [[4 (TERT BUTYL)PHENYL]THIO]ACRYLATE; ETHAMBUTOL; ETHYL 2 [4 (TERT BUTYL)BENZOYL]BENZOATE; ETHYL 4 (BENZO[B]THIOPHEN 2 YL) 4 OXOBUT 2 ENOATE; ETHYL 4 4 (BENZO[B]THIOPHEN 2 YL) 4 HYDROXYBUT 2 YNOATE; ETHYL 4 [4 (TERT BUTYL)PHENYL] 4 HYDROXYBUT 2 YNOATE; ETHYL 4 [4 (TERT BUTYL)PHENYL] 4 OXOBUT 2 YNOATE; ETHYL 4 [4 (TERT BUTYL)PHENYL] 4 OXOBUTANOATE; ETHYL 4 [4 (TERT BUTYL)PHENYL]BUT 2 ENOATE; ETHYL 4 [4 (TERT BUTYL)PHENYL]BUTANOATE; ISONIAZID; RIFAMPICIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; MICHAEL ADDITION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM CHELONEI; MYCOBACTERIUM FORTUITUM; MYCOBACTERIUM INTRACELLULARE; MYCOBACTERIUM KANSASII; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; POSIBACTERIA;

ACRYLIC ESTERS; ANTI-TUBERCULOSIS; MICHAEL-ACCEPTOR; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888435178     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.011     Document Type: Article

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