Apoptotic effects of tamoxifen on leukocytes from horse peripheral blood and bronchoalveolar lavage fluid

Veterinary Research Communications

Volumn 37, Issue 4, 2013, Pages 333-338

  Sarmiento, J ^a   Perez, B ^a   Morales, N ^a   Henriquez, C ^a   Vidal, L ^a   Folch, H ^a   Galecio, J S ^a   Moran G ^a  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

Apoptosis; Horse; Tamoxifen

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE; TAMOXIFEN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; FLOW CYTOMETRY; GRANULOCYTE; HORSE; IMMUNOREGULATION; IN VITRO STUDY; LUNG LAVAGE; MONONUCLEAR CELL; NONHUMAN;

EQUIDAE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; GRANULOCYTES; HORSES; LEUKOCYTES; TAMOXIFEN;

EID: 84888434342     PISSN: 01657380     EISSN: 15737446     Source Type: Journal    
DOI: 10.1007/s11259-013-9571-0     Document Type: Article

References (50)

1. Ahn SJ, Yoon MS, Hyuk S, Han W, Yoon YD, Han JS, Noh DY (2003) Phospholipase C-protein kinase C mediated phospholipase D activation pathway is involved in tamoxifen induced apoptosis. J Cell Biochem 89:520-528
2. Ainsworth DM, Grünig G, Matychak MB, Young J, Wagner B, Erb HN, Antczak DF (2003) Recurrent airway obstruction (RAO) in horses is characterized by IFN-g and IL-8 production in bronchoalveolar lavage cells. Vet Immunol Immunopathol 96:83-91
3. Ainsworth DM, Wagner B, Franchini M, Grunig G, Erb H, Tan JY (2006) Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction. Am J Vet Res 67:669-677
4. Ainsworth DM, Wagner B, Erb HN, Young JC, Retallick DE (2007) Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1β and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease. Am J Vet Res 68:1361-1369
5. Akbar AN, Salmon M (1997) Cellular environments and apoptosis: tissue microenvironments control activated T cell death. Immunol Today 18:72-76
6. Babina M, Kirn F, Hoser D, Ernst D, Rohde W, Zuberbier T, Worm M (2010) Tamoxifen counteracts the allergic immune response and improves allergen-induced dermatitis in mice. Clin Exp Allergy 40:1256-1265
7. Breuer J, Mueller U, Locher L, Spallek A, Recknagel S, Uhlig A, Schusser GF (2011) Differentiation of viable, apoptotic and necrotic cells in bronchoalveolar lavage fluid of normal horses and horses with recurrent airway obstruction. Berliner und Muenchener Tieraerztliche Wochenschrift 124:154-160
8. Budtz PE (1999) Role of proliferation and apoptosis in net growth rates of human breast cancer cells (MCF-7) treated with oestradiol and/or tamoxifen. Cell Prolif 32:289-302
9. Cabot MC, Zhang Z, Cao H, Lavie Y, Giuliano AE, Han TY, Jones RC (1997) Tamoxifen activates cellular phospholipase C and D and elicits protein kinase C translocation. Int J Cancer 70:567-574
10. Cameron DA, Keen JC, Dixon JM, Bellamy C, Hanby A, Anderson TJ, Miller WR (2000) Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes. Eur J Cancer 36:845-851
11. Cohen JJ (1999) Apoptosis: mechanisms of life and death in the immune system. J Allergy Clin Immunol 103:548-554
12. Cordeau ME, Joubert P, Dewachi O, Hamid Q, Lavoie JP (2004) IL-4, IL-5 and IFN-g mRNA expression in pulmonary lymphocytes in equine heaves. Vet Immunolo Immunopathol 97:87-96
13. Cormica L, O'Sullivan S, Burke CM, Poulter LW (2001) IFNgamma but not IL-4 T cells of the asthmatic bronchial wall show increased incidence of apoptosis. Clin Exp Allergy 31:731-739
14. Curik I, Fraser D, Eder C, Achmann R, Swinburne J, Binns M, Crameri R, Brem G, Sölkner J, Marti E (2003) Association between MHC gene region and variation of serum IgE levels against specific mould allergens in the horse. Genet Select Evol 35:117-190
15. Datta R, Kojima H, Yoshida K, Kufe D (1997) Caspase-3- mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem 272:20317-20320
16. De Rose V, Cappello P, Sorbello V, Ceccarini B, Gani F, Bosticardo M, Fassio S, Novelli F (2004) IFN-gamma inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis. J Leukoc Biol 76:423-432
17. Debrue M, Hamilton E, Joubert P, Lajoie-Kadoch S, Lavoie JP (2005) Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells. Vet Immunol Immunopathol 105:25-31
18. Dibbert B, Weber M, Nikolaizik WH, Vogt P, Schöni MH, Blaser K, Simon HU (1999) Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci 96:13330-13335
19. Duffy SM, Lawley WJ, Kaur D, Yang W, Bradding P (2003) Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol 112:965-972
20. Eder C, Crameri R, Mayer C, Eicher R, Straub R, Gerber H, Lazary S, Marti E (2000) Allergen-specific IgE levels against crude mould and storage mite extracts and recombinant mould allergens in sera from horses affected with chronic bronchitis. Vet Immunol Immunopathol 73:241-253
21. Eder C, Curik I, Brem G, Crameri R, Bodo I, Habe F, Lazary S, Sölkner J, Marti E (2001) Influence of environmental and genetic factors on allergen-specific immunoglobulin E levels in sera from Lipizzan horses. Equine Vet J 33:714-720
22. Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF (2007) Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol 19:685-693
23. Franchini M, Gill U, Von Fellenberg R, Bracher VV (2000) Interleukin-8 concentration and neutrophil chemotactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am J Vet Res 11:1369-1374
24. Gerber V, Lindberg A, Berney C, Robinson NE (2004) Airway mucus in recurrent airway obstruction - short-term response to environmental challenge. J Vet Inter Med 18:92-97
25. Giguere S, Viel L, Lee E, MacKay RJ, Hernandez J, Franchini M (2002) Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet Immunol Immunopathol 85:147-158
26. Halliwell REW, McGorum BC, Irving P, Dixon PM (1993) Local and systemic antibody production in horses affected with chronic obstructive pulmonary disease. Vet Immunol Immunopathol 38:201-205
27. Haslett C (1999) Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 160:S5-S11
28. Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ (1999) Resistance to Fas-mediated T cell apoptosis in asthma. J Immunol 162:1717-1722
29. Kisanga ER, Gjerde J, Guerrieri-Gonzaga A, Pigatto F, Pesci-Feltri A, Robertson C, Serrano D, Pelosi G, Decensi A, Lien EA (2004) Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial. Clin Cancer Res 10:2336-2343
30. Künzle F, Gerber V, van der Haegen A, Wampfler B, Straub R, Marti E (2007) IgE-bearing cells in bronchoalveolar lavage fluid and allergen-specific IgE levels in sera from RAO-affected horses. J Vet Med A Physiol Pathol Clin Med 54:40-47
31. Lavoie JP, Maghni K, Desnoyers M, Taha R, Martin JG, Hamid Q (2001) Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am J Respir Crit Care Med 164:1410-1413
32. Leguillette R (2003) Recurrent airway obstruction-heaves. Vet Clin North Am Equine Pract 19:63-68
33. Marchette LC, Marchette BE, Abraham WM, Wanner A (1985) The effect of systemic hydration on normal and impaired mucociliary function. Pediatr Pulmonol 1:107-111
34. Morán G, Burgos R, Araya O, Folch H (2010a) In vitro bioassay to detect reaginic antibodies from the serum of horses affected with recurrent airway obstruction. Vet Res Commun 34:91-99
35. Morán G, Folch H, Burgos R, Araya O, Barria M (2010b) Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with recurrent airway obstruction by an in vitro bioassay. Vet Res Commun 34:719-726
36. Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria A (2011) Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction. Vet Res Commun 35:447-456
37. Moran G, Perez B, Morales N, Vidal L, Galecio JS, Vasquez N, Folch H, Henriquez C (2012) Apoptotic effect of Tamoxifen on neutrophils bronchial cells in horses with recurrent airway obstruction: a new therapeutic approach. Immunology (Supp) 137:438-439
38. Müller M, Grunewald J, Olgart-Höglund C, Dahlén B, Eklund A, Stridh H (2006) Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects. Eur Respir J 28:513-522
39. O'Brian CA, Ward NE, Anderson BW (1988) Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme. J Natl Cancer Inst 80:1628-1633
40. Riihimäki M, Raine A, Art T, Lekeux P, Couëtil L, Pringle J (2008) Partial divergence of cytokine mRNA expression bronchial tissues compared to broncheoalveolar lavage cells in horses with recurrent airway obstruction. Vet Immunol Immunopathol 122:256-264
41. Robinson NE (2001) International workshop on equine chronic airway disease Michigan State University. Equine Vet J 33:5-19
42. Schmallenbach KH, Rahman I, Sasse HH, Dixon PM, Halliwell RE, McGorum BC, Miller HR (1998) Studies on pulmonary and systemic Aspergillus Fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD). Vet Immunol Immunopathol 66:245-256
43. Spinozzi F, Fizzotti M, Agea E, Piattoni S, Droetto S, Russano A, Forenza N, Bassotti G, Grignani F, Bertotto A (1998) Defective expression of Fas messenger RNA and FAS receptor on pulmonary T cells from patients with asthma. Ann Intern Med 128:363-369
44. Stearns V, Johnson MD, Rae JM, Morocho A, Novielli A, Bhargava P, Hayes DF, Desta Z, Flockhart DA (2003) Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764
45. Tahon L, Baselgia S, Gerber V, Doherr MG, Straub R, Robinson NE, Marti E (2009) In vitro allergy test compared to intradermal testing in horses with recurrent airway obstruction. Vet Immunol Immunopathol 127:85-93
46. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
47. Tong J, Bandulwala HS, Clay BS, Anders RA, Shilling RA, Balachandran DD, Chen B, Weinstock JV, Solway J, Hamann KJ, Sperling AI (2006) Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma. J Exp Med 203:1173-1184
48. Turlej RK, Fievez L, Sandersen CF, Dogné S, Kirschvink N, Lekeux P, Bureau F (2001) Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signaling pathway. Thorax 56:696-702
49. Vignola AM, Chanez P, Chiappara G, Siena L, Merendino A, Reina C, Gagliardo R, Profita M, Bousquet J, Bonsignore G (1999) Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis. J Allergy Clin Immunol 103:563-573
50. Zizzo G, Cohen PL (2013) IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol 190:5237-5246