Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells

Veterinary Immunology and Immunopathology

Volumn 105, Issue 1-2, 2005, Pages 25-31

  Debrue, Marie ^a   Hamilton, Emma ^a   Joubert, Philippe ^b   Lajoie Kadoch, Stéphane ^b   Lavoie, Jean Pierre ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Cytokine; Horses; IL 17; Lung; Neutrophils; Recurrent airway obstruction

Indexed keywords

CD3 ANTIGEN; CYTOKINE; INTERLEUKIN 17; MESSENGER RNA;

AIRWAY OBSTRUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; HORSE; LEUKOCYTE ACTIVATION; LUNG FUNCTION TEST; LUNG LAVAGE; LYMPHOCYTE COUNT; NEUTROPHIL; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; ANIMAL DISEASE; BIOSYNTHESIS; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HORSE DISEASE; IMMUNOLOGY; NONPARAMETRIC TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

AIRWAY OBSTRUCTION; ANIMALS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; GENE EXPRESSION REGULATION; HORSE DISEASES; HORSES; INTERLEUKIN-17; LYMPHOCYTE COUNT; NEUTROPHILS; RESPIRATORY FUNCTION TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 18744404249     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2004.12.013     Document Type: Article

References (43)

1. Aggarwal, S., Gurney, A.L., 2002. IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71, 1-8.
2. Ainsworth, D.M., Grunig, G., Matychak, M.B., Young, J., Wagner, B., Erb, H.N., Antczak, D.F., 2003. Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells. Vet. Immunol. Immunopathol. 96, 83-91.
3. Albanesi, C., Scarponi, C., Cavani, A., Federici, M., Nasorri, F., Girolomoni, G., 2000. Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma and interleukin-4-induced activation of human keratinocytes. J. Invest. Dermatol. 115, 81-87.
4. Barczyk, A., Pierzchala, W., Sozanska, E., 2003. Intreleukin-17 in sputum correlates with airway hyperresponsiveness to metacholine. Respir. Med. 97, 726-733.
5. Bowles, K.S., Beadle, R.E., Mouch, S., Pourciau, S.S., Littlefield-Chabaud, M.A., Le Blanc, C., Mistric, L., Fernaglich, D., Horohov, D.W., 2002. A novel model for equine recurrent airway obstruction. Vet. Immunol. Immunopathol. 87, 385-389.
6. Chakir, J., Shannon, J., Molet, S., Fukakusa, M., Laviolette, M., Boulet, L.-P., Hamid, Q.A., 2003. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J. Allergy Clin. Immunol. 111, 1293-1298.
7. Chen, Y., Thai, P., Zhao, Y.H., DeSouza, M.M., Wu, R., 2003. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J. Biol. Chem. 278, 17036-17043.
8. Cordeau, M.E., Joubert, P., Dewachi, O., Hamid, Q.A., Lavoie, J.P., 2004. IL-4, IL-5 anf INF-gamma mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol. Immunopathol. 97, 87-96.
9. Cosio Piqueras, M.G., Cosio, M.G., 2001. Disease of the airways in chronic obstructive pulmonary disease. Eur. Respir. J. 34 (Suppl.), 41s-49s.
10. Dagleish, M.P., Pemberton, A.D., Brazil, T.J., McAleese, S.M., Miller, H.R., Scudamore, C.L., 1999. Kinetics of equine neutrophil elastase release and superoxide anion generation following secretagogue activation: a potential mechanism for antiproteinase inactivation. Vet. Immunol. Immunopathol. 72, 257-275.
11. Fairbairn, S.M., Page, C.P., Lees, P., Cunningham, F.M., 1993. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin. Exp. Allergy 23, 821-828.
12. Ferretti, S., Bonneau, O., Dubois, G.R., Jones, C.E., Trifilieff, A., 2003. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170, 2106-2112.
13. Fossiez, F., Banchereau, J., Murray, R., Van Kooten, C., Garrone, P., Lebecque, S., 1998. Interleukin-17. Int. Rev. Immunol. 16, 541-551.
14. Franchini, M., Gill, U., von Fellenberg, R., Bracher, V.D., 2000. Interleukin-8 concentration and neutrophil chemotactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am. J. Vet. Res. 61, 1369-1374.
15. Gerber, H., Robinson, N.E., Venta, R.J., Rawson, J., Jefcoat, A.M., Hotchkiss, J.A., 2003. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet. J. 35, 252-257.
16. Giguère, S., Viel, L., Lee, E., MacKay, R.J., Hernandez, J., Franchini, M., 2002. cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet. Immunol. Immunopathol. 85, 147-158.
17. Happel, K.I., Zheng, M., Young, E., Quinton, L.J., Lockhart, E., Ramday, A.J., Shellito, J.E., Schurr, J.R., Bagby, G.J., Nelson, S., Kolls, J.K., 2003. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol. 170, 4432-4436.
18. Hellings, P.W., Kasran, A., Liu, Z., Vandekerckhove, P., Wuyts, A., Overbergh, L., Mathieu, C., Ceuppens, J.L., 2003. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 28, 42-50.
19. Holcombe, S.J., Jackson, C., Gerber, H., Jefcoat, C., Berney, C., Eberhardt, S., Robinson, N.E., 2001. Stabling is associated with airways inflammation in young Arabian horses. Equine Vet. J. 33, 244-249.
20. Hoshino, H., Laan, M., Sjostrand, M., Lotvall, J., Skoogh, B.E., Linden, A., 2000. Increased elastase and myeloperoxydase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J. Allergy Clin. Immunol. 105, 143-149.
21. Hurst, S.D., Muchamuel, T., Gorman, D.M., Gilbert, J.M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T.T., Brieland, J.K., Zurawski, S.M., Chapman, R.W., Zurawski, G., Coffman, R.L., 2002. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol. 169, 443-453.
22. Hymowitz, S.G., Filvaroff, E.H., Yin, J.P., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R.F., Pan, G., Gurney, A.L., de Vos, A.M., Starovasnik, M.A., 2001. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20, 5332-5341.
23. Jean, D., Vrins, A., Lavoie, J.P., 1999. Monthly, daily, and circadian variations of measurements of pulmonary mechanics in horses with chronic obstructive pulmonary disease. Am. J. Vet. Res. 60, 1341-1346.
24. Laan, M., Cui, Z.H., Hoshino, H., Lotvall, J., Sjostrand, M., Gruenert, D.C., Skoogh, B.E., Linden, A., 1999. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162, 2347-2352.
25. Lavoie, J.P., Maghni, K., Desnoyers, M., Taha, R., Martin, J.G., Hamid, Q.A., 2001. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am. J. Respir. Crit. Care Med. 164, 1410-1413.
26. Lee, J., Ho, W.H., Maruoka, M., Corpuz, R.T., Baldwin, D.T., Foster, J.S., Goddard, A.D., Yansura, D.G., Vandlen, R.L., Wood, W.I., Gurney, A.L., 2001. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh 1. J. Biol. Chem. 276, 1660-1664.
27. Li, H., Chen, J., Huang, A., Stinson, J., Heldens, S., Foster, J., Dowd, P., Gurney, A.L., Wood, I.W., 2000. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc. Natl. Acad. Sci. 97, 773-778.
28. Linden, A., Adachi, M., 2002. Neutrophilic airway inflammation and IL-17. Allergy 57, 769-775.
29. Linden, A., Hoshino, H., Laan, M., 2000. Airway neutrophils and interleukin-17. Eur. Respir. J. 15, 973-977.
30. Molet, S., Hamid, Q.A., Davoine, F., Nutku, E., Taha, R., Pagé, N., Olivenstein, R., Elias, J., Chakir, J., 2001. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 108, 430-438.
31. Moseley, T.A., Haudenschild, D.R., Rose, L., Reddi, A.M., 2003. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14, 155-174.
32. Pirie, R.S., Collie, D.D., Dixon, P.M., McGorum, B.C., 2003. Inhalated endotoxin and organic dust paticulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clin. Exp. Allergy 33, 676-683.
33. Pirie, R.S., Dixon, P.M., Collie, D.D., McGorum, B.C., 2001. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Vet. J. 33, 311-318.
34. Prause, O., Laan, M., Lotvall, J., Linden, A., 2003. Pharmacological modulation of intreleukin-17-induced GCP-2, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. Eur. J. Pharmacol. 462, 193-198.
35. Robinson, N.E., Derksen, F.J., Olszewski, M.A., Buechner-Maxwell, V.A., 1996. The pathogenesis of chronic obstructive pulmonary disease of horses. Br. Vet. J. 152, 283-306.
36. Robinson, N.E., Hamid, Q.A., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A.M., Corrigan, C., Durhan, S.R., Kay, A.B., 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326, 298-394.
37. Shi, Y., Ullrich, S.S., Zhang, J., Connolly, K., Grzegorzewski, K.J., Barber, M.C., Wang, W., Wathen, K., Hodge, V., Fisher, C.L., Olsen, H., Ruben, S.M., Knyazev, I., Cho, Y.H., Kao, V., Wilkinson, K.A., Carrell, J.A., Ebner, R., 2000. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem. 275, 19167-19176.
38. Starnes, T., Robertson, M.J., Sledge, G., Kelich, S., Nakshatri, H., Broxmeyer, H.E., Hromas, R., 2001. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167, 4137-4140.
39. Tremblay, G.M., Ferland, C., Lapointe, J.M., Vrins, A., Lavoie, J.P., Cormier, Y., 1993. Effect of stabling on bronchoalveolar cells obtained from normal and COPD horses. Equine Vet. J. 25, 194-197.
40. Wong, C.K., Ho, C.Y., Li, E.K., Lam, C.W., 2000. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9, 589-593.
41. Yao, Z., Fanslow, W.C., Seldin, M.F., Rousseau, A.M., Painter, S.L., Comeau, M.R., Cohen, J.I., Spriggs, M.K., 1995a. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3, 811-821.
42. Yao, Z., Painter, S.L., Fanslow, W.C., Ulrich, D., Macduff, B.M., Spriggs, M.K., Armitage, R.J., 1995b. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155, 5483-5486.
43. Yao, Z., Spriggs, M.K., Derry, J.M., Strockbine, L., Park, L.S., VandenBos, T., Zappone, J.D., Painter, S.L., Armitage, R.J., 1997. Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9, 794-800.