IFN-γ but not IL-4 T cells of the asthmatic bronchial wall show increased incidence of apoptosis

Clinical and Experimental Allergy

Volumn 31, Issue 5, 2001, Pages 731-739

  Cormican, L ^a   O'Sullivan, S ^a   Burke, C M ^b   Poulter, L W ^a,b  

^a Royal College of Surgeons in Ireland   (Ireland)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Apoptosis; Asthma; Bcl 2; Bronchial biopsy; IFN ; IL 4; TUNEL

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FAS LIGAND; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; PROTEIN BCL 2;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; ASTHMA; BRONCHOSCOPY; BRONCHUS; BRONCHUS BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOLESCENT; ADULT; APOPTOSIS; ASTHMA; BIOPSY; BRONCHI; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION; GENES, BCL-2; HLA-DR ANTIGENS; HUMANS; IN SITU NICK-END LABELING; INCIDENCE; INTERFERON TYPE II; INTERLEUKIN-4; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0034846791     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01099.x     Document Type: Article

References (27)

1. T cells and eosinophils in the pathogenesis of asthma, Immunol Today
2. Asthma
3. Human Th1 and Th2 lymphocytes: Their role in the pathophysiology of atopy
4. CD4 T-lymphocyte activation in acute severe asthma: Relationship to disease severity and atopic status
5. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
6. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness
7. + cells in human allergic diseases
8. Allergen-induced cytokine production in atopic disease and its relationship to disease severity
9. + T cells are important for the balance between protective and pathogenic cell-mediated immunity
10. Establishment of stable, cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major
11. Autocrine feedback death and the regulation of mature T lymphocyte antigen responses
12. Eosinophil apoptosis and the resolution of airway inflammation in asthma
13. Resolution of acute inflammation and the role of apoptosis in the tissue late of granulocytes
14. Pulmonary immune cells in health and disease: The cosinophil leukocyte (Part 1)
15. Evauation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis
16. Apoptosis, proliferation, and expression of Bc1-2, FAS, and FAS ligand in bronchial biopsies from asthmatics
17. Defective expression of Fas messanger RNA and FAS receptor on pulmonary T cells from patients with asthma
18. Enhanced expression of fas ligand (CD95L) on T cells after segmental allergen provocation in asthma
19. Resistance to FAS-mediated T cell apoptosis in asthma
20. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma
21. Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time
22. Relative effects of inhaled corticosteroids on immunopathology and physiology in asthma: A controlled study
23. Allergic and non-allergics have distinct patterns of T cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
24. Expression of the Fas ligand in cells of T cell lineage
25. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death
26. Th1 and Th2 subsets equally undergo Fas-dependent and -independent áctivation-induced cell death
27. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis