Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects

European Respiratory Journal

Volumn 28, Issue 3, 2006, Pages 513-522

  Müller, Malin ^a   Grunewald, J ^a   Olgart Hoglund C ^a,b   Dahlen B ^a   Eklund, A ^a   Stridh, H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Asthma; Bronchoalveolar lavage; Caspases; Lymphocytes; Tributyltin

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CASPASE 3; METHACHOLINE; PROTEIN BCL 2; SODIUM CHLORIDE; TRIBUTYLTIN;

ADULT; ALLERGIC ASTHMA; APOPTOSIS; ARTICLE; CELL ASSAY; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG LAVAGE; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROVOCATION TEST; SENSITIVITY ANALYSIS;

ADULT; ALLERGENS; APOPTOSIS; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 3; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LUNG; LYMPHOCYTES; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; TRIALKYLTIN COMPOUNDS;

EID: 33751297997     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.06.00118505     Document Type: Article

References (50)

1. Kay AB. The role of T lymphocytes in asthma. Chem Immunol Allergy 2006; 91: 59-75.
2. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142: 1407-1413.
3. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992; 146:500-506.
4. Vignola AM, Chanez P, Chiappara G, et al. Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis. J Allergy Clin Immunol 1999; 103: 563-573.
5. Cormican L, O'Sullivan S, Burke CM, Poulter LW. IFN-gamma but not IL-4 T cells of the asthmatic bronchial wall show increased incidence of apoptosis. Clin Exp Allergy 2001; 31: 731-739.
6. Hamzaoui A, Hamzaoui K, Salah H, Chabbou A. Lymphocytes apoptosis in patients with acute exacerbation of asthma. Mediators Inflamm 1999; 8: 237-243.
7. Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ. Resistance to Fas-mediated T cell apoptosis in asthma. J Immunol 1999; 162: 1717-1722.
8. Lamb JP, James A, Carroll N, Siena L, Elliot J, Vignola AM. Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma. Eur Respir J 2005; 26: 265-270.
9. Krueger A, Fas SC, Baumann S, Krammer PH. The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 2003; 193: 58-69.
10. Hildeman DA, Zhu Y, Mitchell TC, Kappler J, Marrack P. Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol 2002; 14: 354-359.
11. Green DR, Droin N, Pinkoski M. Activation-induced cell death in T cells. Immunol Rev 2003; 193: 70-81.
12. Budd RC. Activation-induced cell death. Curr Opin Immunol 2001; 13: 356-362.
13. Krammer PH. CD95's deadly mission in the immune system. Nature 2000; 407: 789-795.
14. Green DR. Overview: apoptotic signaling pathways in the immune system. Immunol Rev 2003; 193: 5-9.
15. Sordet O, Rebe C, Plenchette S, et al. Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood 2002; 100: 4446-4453.
16. Fernando P, Brunette S, Megeney LA. Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J 2005; 19: 1671-1673.
17. Zermati Y, Garrido C, Amsellem S, et al. Caspase activation is required for terminal erythroid differentiation. J Exp Med 2001; 193: 247-254.
18. Fernando P, Kelly JF, Balazsi K, Slack RS, Megeney LA. Caspase 3 activity is required for skeletal muscle differentiation. Proc Natl Acad Sci USA 2002; 99: 11025-11030.
19. Alam A, Cohen LY, Aouad S, Sekaly RP. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med 1999; 190: 1879-1890.
20. Kennedy NJ, Kataoka T, Tschopp J, Budd RC. Caspase activation is required for T cell proliferation. J Exp Med 1999; 190: 1891-1896.
21. Launay S, Hermine O, Fontenay M, Kroemer G, Solary E, Garrido C. Vital functions for lethal caspases. Oncogene 2005; 24: 5137-5148.
22. Stridh H, Planck A, Gigliotti D, Eklund A, Grunewald J. Apoptosis resistant bronchoalveolar lavage (BAL) fluid lymphocytes in sarcoidosis. Thorax 2002; 57: 897-901.
23. Stridh H, Gigliotti D, Orrenius S, Cotgreave I. The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis. Biochem Biophys Res Commun 1999; 266: 460-465.
24. Stridh H, Kimland M, Jones DP, Orrenius S, Hampton MB. Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis. FEBS Lett 1998; 429: 351-355.
25. Stridh H, Orrenius S, Hampton MB. Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin. Toxicol Appl Pharmacol 1999; 156: 141-146.
26. Gyllfors P, Kumlin M, Dahlen SE, Gaber F, Ehrs PO, Dahlen B. Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosythesis. Thorax 2005; 60: 902-908.
27. Dahlen B, Zetterstrom O, Bjorck T, Dahlen SE. The leukotriene-antagonist ICI-204,219 inhibits the early air-way reaction to cumulative bronchial challenge with allergen in atopic asthmatics. Eur Respir J 1994; 7: 324-331.
28. Katchar K, Wahlstrom J, Eklund A, Grunewald J. Highly activated T-cell receptor AV2S3(+) CD4(+) lung T-cell expansions in pulmonary sarcoidosis. Am J Respir Crit Care Med 2001; 163: 1540-1545.
29. Eklund A, Blaschke E. Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis. Thorax 1986; 41: 629-634.
30. Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989; 140: 1745-1753.
31. Robinson DS, Bentley AM, Hartnell A, Kay AB, Durham SR. Activated memory T helper cells in broncho-alveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness. Thorax 1993; 48: 26-32.
32. Muller M, Grunewald J, Gigliotti D, Eklund A, Stridh H. T-cell activation and the development of an apoptosis-resistant CD45RO+ T-cell population. Scand J Immunol 2003; 57: 254-260.
33. Krug N, Erpenbeck VJ, Balke K, et al. Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gammadelta T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 2001; 25: 125-131.
34. Larche M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2003; 111: 450-463.
35. Jeffery PK, Laitinen A, Venge P. Biopsy markers of airway inflammation and remodelling. Respir Med 2000; 94: Suppl F, S9-S15.
36. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001; 344: 350-362.
37. Druilhe A, Wallaert B, Tsicopoulos A, et al. Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics. Am J Respir Cell Mol Biol 1998; 19: 747-757.
38. Krug N, Tschernig T, Balke K, et al. Enhanced expression of fas ligand (CD95L) on T cells after segmental allergen provocation in asthma. J Allergy Clin Immunol 1999; 103: 649-655.
39. Fadeel B, Zhivotovsky B, Orrenius S. All along the watchtower: on the regulation of apoptosis regulators. FASEB J 1999; 13: 1647-1657.
40. Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med 2005; 258: 479-517.
41. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
42. Ying S, Meng Q, Taborda-Barata L, Kay AB. Association of apoptosis of neutrophils and eosinophils and their ingestion by macrophages with resolution of the allergen-induced cutaneous late-phase response in atopic human subjects. Proc Assoc Am Physicians 1997; 109: 42-50.
43. Ying S, Khan LN, Meng Q, Barnes NC, Kay AB. Cyclosporin A, apoptosis of BAL T-cells and expression of Bcl-2 in asthmatics. Eur Respir J 2003; 22: 207-212.
44. Oldfield WL, Kay AB, Larche M. Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 2001; 167: 1734-1739.
45. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987; 136: 740-751.
46. Gonzalez MC, Diaz P, Galleguillos FR, Ancic P, Cromwell O, Kay AB. Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) T-cells in asthma. Relative increases in OKT8 cells in single early responders compared with those in late-phase responders. Am Rev Respir Dis 1987; 136: 600-604.
47. Wilhelm S, Wagner H, Hacker G. Activation of caspase-3-like enzymes in non-apoptotic T cells. Eur J Immunol 1998; 28: 891-900.
48. Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 2003; 171: 247-256.
49. Woo M, Hakem R, Furlonger C, et al. Caspase-3 regulate cell cycle in B cells: a consequence of substrate specificity Nat Immunol 2003; 4: 1016-1022.
50. Wu W, Misra RS, Russell JQ, Flavell RA, Rincon M, Budd RC. Proteolytic regulation of NFATc2 and NFAT activity by caspase-3. J Biol Chem 2006; 281: 10682-10690.