Physico-chemical characterization in solution and in the solid state of clonazepam complexes with native and chemically-modified cyclodextrins

Journal of Pharmaceutical and Biomedical Analysis

Volumn 89, Issue , 2014, Pages 142-149

  Mennini, Natascia ^a   Bragagni, Marco ^a   Maestrelli, Francesca ^a   Mura, Paola ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Clonazepam; Cyclodextrin complexation; Differential scanning calorimetry; Dissolution rate; Phase solubility analysis

Indexed keywords

CLONAZEPAM; CYCLODEXTRIN;

ARTICLE; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG SOLUBILITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID STATE; X RAY POWDER DIFFRACTION;

CLONAZEPAM; CYCLODEXTRIN COMPLEXATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION RATE; PHASE-SOLUBILITY ANALYSIS;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CLONAZEPAM; CYCLODEXTRINS; PHYSICOCHEMICAL PHENOMENA; POWDERS; SOLUBILITY; SOLUTIONS; X-RAY DIFFRACTION;

EID: 84888400887     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.11.009     Document Type: Article

References (27)

1. Winkler D., Willeit M., Wolf R., Stamenkovic M., Tauscher J., Pjrek E., Konstantinidis A., Schindler S., Barnas C., Kasper S. Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. Eur. Neuropsychopharmacol. 2003, 13:129-134.
2. Lima L. Region-selective reduction of brain serotonin turnover rate and serotonin agonist-induced behavior in mice treated with clonazepam. Pharmacol. Biochem. Behav. 1991, 39:671-676.
3. Amidon G.L., Lennernas H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995, 12:413-420.
4. Hammad M.A., Müller B.W. Solubility and stability of clonazepam in mixed micelles. Int. J. Pharm. 1998, 169:55-64.
5. Loftsson T., Brewster M.E., Másson M. Role of cyclodextrin in improving oral drug delivery. Am. J. Drug Deliv. 2004, 2:261-275.
6. Tommasini S., Raneri D., Ficarra R., Calabrò M.L., Stancanelli R., Ficarra P. Improvement in solubility and dissolution rate of flavonoids by complexation with β-cyclodextrin. J. Pharm. Biomed. Anal. 2004, 35:379-387.
7. Hassan H.A., Al-Marzouqi A.H., Jobe B., Hamza A.H., Ramadan G.A. Enhancement of dissolution amount and in vivo bioavailability of itraconazole by complexation with β-cyclodextrin using supercritical carbon dioxide. J. Pharm. Biomed. Anal. 2007, 45:243-250.
8. Veiga M.D., Merino M., Cirri M., Maestrelli F., Mura P. Comparative study on triclosan interactions in solution and in the solid state with naturally and chemically modified cyclodextrins. J. Incl. Phenom. Macrocycl. Chem. 2005, 37:995-1002.
9. Jug M., Maestrelli F., Mura P. Native and polymeric β-cyclodextrins in performance improvement of chitosan films aimed for buccal delivery of poorly soluble drugs. J. Incl. Phenom. Macrocycl. Chem. 2012, 74:87-97.
10. McCormack B., Gregoriadis G. Drugs-in-cyclodextrins-in liposomes: an approach to controlling the fate of water insoluble drugs in vivo. Int. J. Pharm. 1998, 162:59-69.
11. Mura P., Maestrelli F., Cecchi M., Almeida A. Development of a new delivery system consisting in drug-in cyclodextrin-in PLGA nanoparticles. J. Microencapsul. 2010, 27:479-486.
12. Maestrelli F., González-Rodríguez M.L., Rabasco A.M., Ghelardini C., Mura P. New drug-in cyclodextrin-in deformable liposomes formulations to improve the therapeutic efficacy of local anaesthetics. Int. J. Pharm. 2010, 395:222-231.
13. Cirri M., Bragagni M., Mennini N., Mura P. Development of a new delivery system consisting in drug-in cyclodextrin-in nanostructured lipid carriers for ketoprofen topical delivery. Eur. J. Pharm. Biopharm. 2012, 80:46-53.
14. Loftsson T., Masson M. Cyclodextrins in topical drug formulations: theory and practice. Int. J. Pharm. 2001, 225:15-30.
15. Corti P., Dreassi E., Mura P., Perruccio P.L. In vitro studies of simulated percutaneous absorption: influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches. Pharm. Acta Helv. 1998, 72:263-269.
16. Mura P., Faucci M.T., Bramanti G., Corti P. Evaluation of transcutol as a clonazepam transdermal permeation enhancer from hydrophilic gel formulations. Eur. J. Pharm. Sci. 2000, 9:365-372.
17. Puglia C., Bonina F., Trapani G., Franco M., Ricci M. Evaluation of in vitro percutaneous absorption of lorazepam and clonazepam from hydro-alcoholic gel formulations. Int. J. Pharm. 2001, 228:79-87.
18. Shokri J., Nokhodchi A., Dashbolaghi A., Hassan-Zadeh D., Ghafourian T., BarzegarJalali M. The effect of surfactants on the skin penetration of Diazepam. Int. J. Pharm. 2001, 228:99-107.
19. Higuchi T., Connors K. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965, 7:117-212.
20. Maestrelli F., Cecchi M., Cirri M., Capasso G., Mennini N., Mura P. Comparative study of oxaprozin complexation with natural and chemically-modified cyclodextrins in solution and in the solid state. J. Incl. Phenom. Macrocycl. Chem. 2009, 63:17-25.
21. Patel R., Purohit N. Physico-chemical characterization and in vitro dissolution assessment of clonazepam-cyclodextrins inclusion compounds. AAPS PharmSciTech 2009, 10:1301-1312.
22. Uekama K., Narisawa S., Hyrayama F., Otagiri M. Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation. Int. J. Pharm. 1983, 16:327-338.
23. Cirri M., Maestrelli F., Mennini N., Mura P. Influence of the preparation method on the physical-chemical properties of ketoprofen-cyclodextrin-phosphatidylcholine ternary systems. J. Pharm. Biomed. Anal. 2009, 50:690-694.
24. Bragagni M., Maestrelli F., Mura P. Physical chemical characterization of binary systems of prilocaine hydrochloride with triacetyl-β-cyclodextrin. J. Incl. Phenom. Macrocycl. Chem. 2010, 68:437-445.
25. Mura P., Cirri M., Faucci M.T., Ginès-Dorado J.M., Bettinetti G.P. Investigation of the effects of grinding and co-grinding on physicochemical properties of glisentide. J. Pharm. Biomed. Anal. 2002, 30:227-237.
26. Mura P., Bettinetti G.P., Faucci M.T., Sorrenti M., Negri A. Interaction of naproxen with crystalline and amorphous methylated-β-cyclodextrin in the liquid and solid state. Supramol. Chem. 2001, 12:379-389.
27. Jug M., Kosalec I., Maestrelli F., Mura P. Physicochemical characterization of triclosan complexes with β-cyclodextrin and its water-soluble polymeric derivative. J. Pharm. Biomed. Anal. 2011, 54:1030-1039.