Poly(N-isopropylacrylamide-co-hydroxyethylacrylamide) thermosensitive microspheres: The size of microgels dictates the pulsatile release mechanism

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 614-623

  Fundueanu, Gheorghe ^a   Constantin, Marieta ^a   Asmarandei, Ionela ^a   Bucatariu, Sanda ^a   Harabagiu, Valeria ^a   Ascenzi, Paolo ^b   Simionescu, Bogdan C ^a,c  

^a PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Romania)

^b ROMA TRE UNIVERSITY   (Italy)

^c GHEORGHE ASACHI TECHNICAL UNIVERSITY OF IASI   (Romania)

Author keywords

Drug delivery systems; Lower critical solution temperature; Microspheres; Thermo responsive polymer; Volume phase transition temperature

Indexed keywords

GLUTARALDEHYDE; HYDROXYL GROUP; INDOMETACIN; MICROSPHERE; POLY(N ISOPROPYLACRYLAMIDE CO HYDROXYETHYLACRYLAMIDE); UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; EVAPORATION; HEAT SENSITIVITY; LOWER CRITICAL SOLUTION TEMPERATURE; PHASE TRANSITION; PULSATILE DRUG RELEASE; TRANSITION TEMPERATURE; VOLUME PHASE TRANSITION TEMPERATURE;

AIBN; CLOUD POINT; CP; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEMS; DSC; ENVIRONMENTAL SCANNING ELECTRON MICROSCOPY; ESEM; GA; GLASS TRANSITION TEMPERATURE; GLUTARALDEHYDE; HEAAM; LCST; LOWER CRITICAL SOLUTION TEMPERATURE; M(N); M(W); MICROSPHERES; N,N′-AZOBISISOBUTYRONITRILE; N-HYDROXYETHYLACRYLAMIDE; N-ISOPROPYLACRYLAMIDE; NIPAAM; NUMBER-AVERAGE MOLECULAR WEIGHT; PB; PHOSPHATE BUFFER; PI; POLY(N-ISOPROPYLACRYLAMIDE); POLY(N-ISOPROPYLACRYLAMIDE-CO-N-HYDROXYETHYLACRYLAMIDE); POLY(NIPAAM); POLY(NIPAAM-CO-HEAAM); POLYDISPERSITY INDEX; TG; THERMO-RESPONSIVE POLYMER; VOLUME PHASE TRANSITION TEMPERATURE; VPTT; WEIGHT-AVERAGE MOLECULAR WEIGHT;

ACRYLIC RESINS; BODY TEMPERATURE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HUMANS; INDOMETHACIN; MICROSPHERES; PARTICLE SIZE; PHASE TRANSITION; TRANSITION TEMPERATURE;

EID: 84888377712     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.03.023     Document Type: Article

References (33)

1. H. He, X. Cao, and L.J. Lee Design of a novel hydrogel-based intelligent system for controlled drug release J. Control. Release 95 2004 391 402
2. M.J. Taylor, S. Tanna, T.S. Sahota, and B. Voermans Rheological characterisation of dextran-concanavalin A mixtures as a basis for a self-regulated drug delivery device Eur. J. Pharm. Biopharm. 62 2006 94 100
3. C. Liu, Y. Chen, and J. Chen Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery Carbohyd. Polym. 79 2010 500 506
4. J.J. Kim, and K. Park Modulated insulin delivery from glucose-sensitive hydrogel dosage forms J. Control. Release 77 2001 39 47
5. G. Fundueanu, M. Constantin, and P. Ascenzi Poly(vinyl alcohol) microspheres with pH- and thermosensitive properties as temperature-controlled drug delivery Acta Biomater. 6 2010 3899 3907
6. H.J. Jung, and A. Chauhan Temperature sensitive contact lenses for triggered ophthalmic drug delivery Biomaterials 33 2012 2289 2300
7. M. Heskins, and J.E. Guillet Solution properties of poly(N- isopropylacrylamide) J. Macromol. Sci. Chem. 2 1968 1441 1455
8. J.H. Priest, S.L. Murry, R.J. Nelson, and A.S. Hoffman Lower critical solution temperatures of aqueous copolymers of N-isopropylacrylamide and other N-substituted acrylamides ACS Symp. Ser. 350 1986 255 264
9. J.-Y. Wu, S.-Q. Liu, P.W.-S. Heng, and Y.-Y. Yang Evaluating proteins release from, and their interactions with, thermosensitive poly(N- isopropylacrylamide) hydrogels J. Control. Release 102 2005 361 372
10. J.-T. Zhang, R. Bhat, and K.D. Jandt Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties Acta Biomater. 5 2009 488 497
11. M. Casolaro, I. Casolaro, and S. Lamponi Stimuli-responsive hydrogels for controlled pilocarpine ocular delivery Eur. J. Pharm. Biopharm. 80 2012 553 561
12. A. Gutowska, J.S. Bark, I.C. Kwon, Y.H. Bae, Y. Cha, and S.W. Kim Squeezing hydrogels for controlled oral drug delivery J. Control. Release 48 1997 141 148
13. L.M. Geever, C.C. Cooney, J.G. Lyons, J.E. Kennedy, M.J.D. Nugent, S. Devery, and C.L. Higginbotham Characterisation and controlled drug release from novel drug-loaded hydrogels Eur. J. Pharm. Biopharm. 69 2008 1147 1159
14. G. Fundueanu, M. Constantin, I. Oanea, V. Harabagiu, P. Ascenzi, and B.C. Simionescu Entrapment and release of drugs by a strict "on-off" mechanism in pullulan microspheres with pendant thermosensitive groups Biomaterials 31 2010 9544 9553
15. M.K. Yoo, Y.K. Sung, Y.M. Lee, and C.S. Cho Effect of polyelectrolyte on the lower critical solution temperature of poly(Nisopropylacrylamide) in the poly(NIPAAm-co-acrylic acid) hydrogel Polymer 41 2000 5713 5719
16. X.-D. Xu, X.-Z. Zhang, S-X. Cheng, R.-X. Zhuo, and J.F. Kennedy A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity Carbohydr. Polym. 68 2007 416 423
17. B. Wang, X.-D. Xu, Z.-C. Wang, S.-X. Cheng, X.-Z. Zhang, and R.-X. Zhuo Synthesis and properties of pH and temperature sensitive P(NIPAAm-co-DMAEMA) hydrogels Colloids Surf. B 64 2008 34 41
18. X.Z. Zhang, and C.C. Chu Fabrication and characterization of microgel impregnated, thermosensitive PNIPAAm hydrogels Polymer 46 2005 9664 9673
19. T.G. Park Temperature modulated protein release from pH/temperature- sensitive hydrogels Biomaterials 20 1999 517 521
20. T. Tanaka, and D.J. Fillmore Kinetics of swelling of gels J. Chem. Phys. 70 1979 1214 1218
21. E. Sato-Matsuo, and T. Tanaka Kinetics of discontinuous volume phase transition of gels J. Chem. Phys. 89 1988 1695 1703
22. A. D'Emanuele, and R. Dinarvand Preparation, characterization, and drug release from thermoresponsive microspheres Int. J. Pharm. 118 1995 237 242
23. G. Fundueanu, M. Constantin, F. Bortolotti, P. Ascenzi, R. Cortesi, and E. Menegatti Preparation and characterization of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide-co-hydroxyethyl acrylate) microspheres as a matrix for the pulsed release of drugs Macromol. Biosci. 5 2005 955 964
24. G. Lewis, D.C. Coughlan, M.E. Lane, and O.I. Corrigan Preparation and release of model drugs from thermally sensitive poly(N-isopropylacrylamide) based macrospheres J. Microencapsulation 23 2006 677 685
25. A. Serres, M. Baudyš, and S.W. Kim Temperature and pH-sensitive polymers for human calcitonin delivery Pharm. Res. 13 1996 196 201
26. C. Ramkissoon-Ganorkar, F. Liu, M. Baudyš, and S.W. Kim Modulating insulin release profile from pH/thermoresponsive polymeric beads through polymer molecular weight J. Control. Release 59 1999 287 298
27. D.C. Coughlan, F.P. Quilty, and O.I. Corrigan Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels J. Control. Release 98 2004 97 114
28. G. Fundueanu, M. Constantin, and P. Ascenzi Poly(N-isopropylacrylamide- co-acrylamide) cross-linked thermoresponsive microspheres obtained from preformed polymers: influence of the physico-chemical characteristics of drugs on their release profiles Acta Biomater. 5 2009 363 373
29. H.G. Schild, M. Muthukumar, and D.A. Tirrell Cononsolvency in mixed aqueous solutions of poly(N-isopropylacrylamide) Macromolecules 24 1991 948 952
30. H.G. Schild Poly(N-isopropylacrylamide): experiment, theory and application Prog. Polym. Sci. 17 1992 163 249
31. M. Constantin, M. Cristea, P. Ascenzi, and G. Fundueanu Lower critical solution temperature versus volume phase transition temperature in thermosensitive drug delivery systems Express Polym. Lett. 5 2011 839 848
32. T. Aoki, M. Kawashima, H. Katono, K. Sanui, N. Ogata, T. Okano, and Y. Sakurai Temperature-responsive interpenetrating polymer networks constructed with poly(acrylic acid) and poly(N,N-dimethylacrylamide) Macromolecules 27 1994 947 952
33. R.-X. Zhuo, and W. Li Preparation and characterization of macroporous poly(N-isopropylacrylamide)hydrogels for the controlled release of proteins J. Polym. Sci. Part A: Polym. Chem. 41 2003 152 159