Poly(N-isopropylacrylamide-co-acrylamide) cross-linked thermoresponsive microspheres obtained from preformed polymers: Influence of the physico-chemical characteristics of drugs on their release profiles

Acta Biomaterialia

Volumn 5, Issue 1, 2009, Pages 363-373

  Fundueanu, Gheorghe ^a,b   Constantin, Marieta ^b   Ascenzi, Paolo ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Romania)

^c ROMA TRE UNIVERSITY   (Italy)

Author keywords

Drug delivery; Equilibrium swelling ratio; Intelligent microspheres; Lower critical solution temperature; pH thermoresponsive copolymers

Indexed keywords

ACRYLIC MONOMERS; AMIDES; CONTROLLED DRUG DELIVERY; CROSSLINKING; DRUG INTERACTIONS; HYDROGELS; HYDROPHILICITY; HYDROPHOBICITY; SCANNING ELECTRON MICROSCOPY; TARGETED DRUG DELIVERY;

CRITICAL SOLUTION TEMPERATURE; EQUILIBRIUM SWELLING; EQUILIBRIUM SWELLING RATIO; INTELLIGENT MICROSPHERE; LOW CRITICAL SOLUTION TEMPERATURE; LOWER CRITICAL; PH/THERMORESPONSIVE COPOLYMER; SWELLING RATIO; THERMO-RESPONSIVE COPOLYMERS; THERMO-RESPONSIVE MICROSPHERES;

MICROSPHERES;

COPOLYMER; CYANOCOBALAMIN; LIDOCAINE; MICROSPHERE; POLY(N ISOPROPYLACRYLAMIDE CO ACRYLAMIDE); PROPRANOLOL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TEMPERATURE DEPENDENCE;

EID: 56349083623     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2008.07.011     Document Type: Article

References (29)

1. Qui Y., and Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 53 (2001) 321-339
2. Zhang X.Z., Zhuo R.X., Cui C.Z., and Zhang J.T. A novel thermo-responsive drug delivery system with positive controlled release. Int J Pharm 235 (2002) 43-50
3. Huang X., and Lowe T.L. Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs. Biomacromolecules 6 (2005) 2131-2139
4. Wu I.Y., Liu S.Q., Heng P.W.S., and Yang Y.Y. Evaluating proteins release from, and their interactions with thermoresponsive poly(N-isopropylacrylamide) hydrogels. J Contr Release 102 (2005) 361-372
5. Li S.K., and D'Emanuele A. Effect of thermal cycling on the properties of thermoresponsive poly (N-isopropylacrylamide) hydrogels. Int J Pharm 267 (2003) 27-34
6. Schild H.G. Poly (N-isopropylacrylamide): experiment, theory, and application. Prog Polym Sci 17 (1992) 163-249
7. Feil H., Bae Y.H., Feijen J., and Kim S.W. Mutual influence of pH and temperature on the swelling of ionizable and thermosensitive hydrogels. Macromolecules 25 (1992) 5528-5530
8. Park T.G., and Hoffman A.S. Synthesis and characterization of pH and/or temperature sensitive hydrogels. J Appl Polym Sci 46 (1992) 659-671
9. Dong L.C., and Hoffman A.S. Synthesis and application of thermally reversible heterogels for drug delivery. J Contr Release 13 (1990) 21-31
10. Park T.G. Temperature modulated protein release from pH/temperature-sensitive hydrogels. Biomaterials 20 (1999) 517-521
11. Yoshida R., Sakai K., Okano T., and Sakurai Y. Modulating the phase transition temperature and thermosensitivity in N-isopropylacrylamide copolymer gels. J Biomater Sci Polym Ed 6 (1994) 585-598
12. Gutowska A., Bae Y.H., Feijen J., and Kim S.W. Heparin release from thermosensitive hydrogels. J Contr Release 22 (1992) 95-104
13. Zhuo R.X., and Li W. Preparation and characterization of macroporous poly (N-isopropylacrylamide) hydrogels for the controlled release of proteins. J Polym Sci A Polym Chem 41 (2003) 152-159
14. Zhang X.Z., Wu D.Q., and Chu C.C. Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials 25 (2004) 3793-3805
15. D'Emanuele A., and Dinarvand R. Preparation, characterization, and drug release from thermoresponsive microspheres. Int J Pharm 118 (1995) 237-242
16. Oktar O., Caglar P., and Seitz W.R. Chemical modulations of thermosensitive poly (N-isopropylacrylamide) microsphere swelling: a new strategy for chemical sensing. Sens Actuat B Chem 104 (2005) 179-185
17. Serres A., Baudyš M., and Kim S.W. Temperature and pH-sensitive polymers for human calcitonin delivery. Pharm Res 13 (1996) 196-201
18. Ramkissoon-Ganorkar C., Liu F., Baudyš M., and Kim S.W. Modulating insulin release profile from pH/thermoresponsive polymeric beads through polymer molecular weight. J Contr Release 59 (1999) 287-298
19. Kim E.J., Cho S.H., and Yuk S.H. Polymeric microspheres composed of pH/temperature-sensitive polymer complex. Biomaterials 22 (2001) 2495-2499
20. Gutowska A., Bark J.S., Kwon I.C., Bae Y.H., Cha Y., and Kim S.W. Squeezing hydrogels for controlled oral drug delivery. J Contr Release 48 (1997) 141-148
21. Shin Y., Chang J.H., Liu J., Williford R., Shin Y.K., and Exarhos G.J. Hybrid nanogels for sustainable positive thermosensitive drug release. J Contr Release 73 (2001) 1-6
22. Fundueanu G., Constantin M., Bortolotti F., Ascenzi P., Cortesi R., and Menegatti E. Preparation and characterization of thermoresponsive poly (N-isopropylacrylamide-co-acrylamide-co-hydroxyethyl acrylate) microspheres as a matrix for the pulsed release of drugs. Macromol Biosci 5 (2005) 955-964
23. Challis B.C., and Challis J.A. Reaction of the carboxamide group. In: Zabicky I. (Ed). The chemistry of the carbonyl group (1970), Interscience Publisher, London 754-759
24. Fundueanu G., Constantin M., Bortolotti F., Ascenzi P., Cortesi R., and Menegatti E. Poly[(N-isopropylacrylamide-co-acrylamide-co-(hydroxyethyl methacrylate)] thermoresponsive microspheres. An accurate method for the determination of the volume phase transition temperature based on solute exclusion technique. Eur Polym J 43 (2007) 3500-3509
25. Wu X.S., Hoffman A.S., and Yager P. Synthesis and characterization of thermally reversible macroporous poly (N-isopropylacrylamide) hydrogels. J Polym Sci A 30 (1992) 2121-2129
26. Matsuo E.S., and Tanaka T. Kinetics of discontinuous volume-phase transition of gels. J Chem Phys 89 (1988) 1695-1703
27. Coughlan D.C., Quilty F.P., and Corrigan O.I. Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly (N-isopropylacrylamide) hydrogels. J Control Release 98 (2004) 97-114
28. Okano T., Bae Y.H., Jacobs H., and Kim S.W. Thermally on-off switching polymers for drug permeation and release. J Control Release 11 (1990) 255-265
29. Bae Y.H., Okano T., and Kim S.W. "On-off" thermocontrol of solute transport: II. Solute release from thermoresponsive hydrogels. Pharm Res 8 (1991) 624-628