Synthesis and properties of pH and temperature sensitive P(NIPAAm-co-DMAEMA) hydrogels

Colloids and Surfaces B: Biointerfaces

Volumn 64, Issue 1, 2008, Pages 34-41

  Wang, Bo ^a,b   Xu, Xiao Ding ^b   Wang, Zong Chun ^a,b   Cheng, Si Xue ^b   Zhang, Xian Zheng ^b   Zhuo, Ren Xi ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Hydrogel; pH sensitive; Temperature sensitive

Indexed keywords

FREE RADICAL POLYMERIZATION; PH EFFECTS; SENSITIVITY ANALYSIS; SWELLING; SYNTHESIS (CHEMICAL); THERMAL EFFECTS;

ETHYLAMIDE PENDANT GROUPS; PH SENSITIVE; TEMPERATURE SENSITIVE;

HYDROGELS;

ACRYLAMIDE DERIVATIVE; AMIDE; N [2 (DIMETHYLAMINO)ETHYL]METHACRYLAMIDE; POLY (N ISOPROPYLACRYLAMIDE); POLY [N ISOPROPYLACRYLAMIDE CO N [2 (DIMETHYLAMINO)ETHYL]METHACRYLAMIDE];

ANALYTIC METHOD; ARTICLE; HYDROGEL; KINETICS; PH; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; SYNTHESIS; TEMPERATURE; TEMPERATURE SENSITIVITY;

ACRYLAMIDES; HEAT; HYDROGELS; HYDROGEN-ION CONCENTRATION; KINETICS; METHACRYLATES; POLYMERS; TEMPERATURE;

EID: 43049124086     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2008.01.001     Document Type: Article

References (45)

1. Yoshida R., Sakai K., Okano T., and Sakurai Y. Pulsatile drug delivery systems using hydrogels. Adv. Drug Deliv. Rev. 11 (1993) 85-108
2. Qiu Y., and Park K. Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53 (2001) 321-339
3. Gil E.S., and Hudson S.M. Stimuli-responsive polymers and their bioconjugates. Prog. Polym. Sci. 24 (2004) 1173-1222
4. Hoffman A.S. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J. Control. Rel. 6 (1987) 297-305
5. Suzuki A., and Tanaka T. Phase transition in polymer gels induced by visible-light. Nature 346 (1990) 345-347
6. Torres-Lugo M., and Peppas N.A. Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 32 (1999) 6646-6651
7. Tanaka T., Nishio I., Sun S.T., and Ueno-Nishio S. Science 218 (1982) 467-469
8. Miyata T., Asami N., and Uragami T. A reversibly antigen-responsive hydrogel. Nature 399 (1999) 766-769
9. Hirokawa Y., and Tanaka T. Volume phase transition in a nonionic gel. J. Chem. Phys. 81 (1984) 6379-6380
10. Zhang X.Z., and Zhuo R.X. Dynamic properties of temperature sensitive poly(N-isopropylacrylamide) gel crosslinked through siloxane linkage. Langmuir 17 (2001) 12-16
11. Wu C., and Zhou S.Q. Laser light scattering study of the phase transition of poly(N-isopropylacrylamide) in water. 1. Single chain. Macromolecules 28 (1995) 8381-8387
12. Winnik F.M. Phase transition of aqueous poly(N-isopropylacrylamide) solutions: a study by non-radiative energy transfer. Polymer 31 (1990) 2125-2134
13. Chee C.K., Rimmer S., Soutar I., and Swanson L. Time-resolved fluorescence anisotropy studies of the temperature-induced intramolecular conformational transition of poly(N-isopropylacrylamide) in dilute aqueous solution. Polymer 38 (1997) 483-486
14. Annaka M., Tanaka C., Nakahira T., Sugiyama M., Aoyagi T., and Okano T. Fluorescence study on the swelling behavior of comb-type grafted poly(N-isopropylacrylamide) hydrogels. Macromolecules 35 (2002) 8173-8179
15. Zhang X.Z., Yang Y.Y., Chung S.T., and Ma K.X. Preparation and characterization of fast response macroporous poly(N-isopropylacrylamide) hydrogels. Langmuir 17 (2001) 6094-6099
16. Zhang X.Z., Yang Y.Y., and Chung S.T. Effect of mixed solvents on characteristics of poly(N-isopropylacrylamide) gels. Langmuir 18 (2002) 2538-2542
17. Zhang X.Z., and Chu C.C. Thermosensitive PNIPAAm cryogel with superfast and stable oscillatory properties. Chem. Commun. 12 (2003) 1446-1447
18. Xu X.D., Zhang X.Z., Yang J., Cheng S.X., Zhuo R.X., and Huang Y.C. Strategy to introduce a pendent micellar structure into poly(N-isopropylacrylamide) hydrogels. Langmuir 23 (2007) 4231-4236
19. Bromberg L.E., and Ron E.S. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv. Drug Deliv. Rev. 31 (1998) 197-221
20. Zhang X.Z., Wu D.Q., and Chu C.C. Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials 25 (2004) 3793-3805
21. Xu X.D., Wei H., Zhang X.Z., Cheng S.X., and Zhuo R.X. Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release. J. Biomed. Mater. Res. A 81 (2007) 418-426
22. Mandracchia D., Pitarresi G., Palumbo F.S., Carlisi B., and Giammona G. pH-sensitive hydrogel based on a novel photocross-linkable copolymer. Biomacromolecules 5 (2004) 1973-1982
23. Liang H.F., Hong M.H., Ho R.M., Chung C.K., Lin Y.H., Chen C.H., and Sung H.W. Novel method using a temperature-sensitive polymer (methylcellulose) to thermally gel aqueous alginate as a pH-sensitive hydrogel. Biomacromolecules 5 (2004) 1917-1925
24. Chen S.C., Wu Y.C., Mi F.L., Lin Y.H., Yu L.C., and Sung H.W. A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J. Control. Rel. 96 (2004) 285-300
25. Chen G.H., and Hoffman A.S. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 373 (1995) 49-52
26. Shibayama M., Fujikawa Y., and Nomura S. Dynamic light scattering study of poly(N-isopropylacrylamide-co-acrylic acid) gels. Macromolecules 29 (1996) 6535-6540
27. Bulmus V., Ding Z., Long C.J., Stayton P.S., and Hoffman A.S. Site-specific polymer-streptavidin bioconjugate for pH-controlled binding and triggered release of biotin. Bioconjugate Chem. 11 (2000) 78-83
28. Chen H., and Hsieh Y.L. Ultrafine hydrogel fibers with dual temperature- and pH-responsive swelling behaviors. J. Polym. Sci. Part A: Polym. Chem. 42 (2004) 6331-6339
29. Zhang J., and Peppas N.A. Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks. Macromolecules 33 (2000) 102-107
30. Kaneko Y., Nakamura S., Sakai K., Aoyagi T., Kikuchi A., Sakurai Y., and Okano T. Rapid deswelling response of poly(N-isopropylacrylamide) hydrogels by the formation of water release channels using poly(ethylene oxide) graft chains. Macromolecules 31 (1998) 6099-6105
31. Yoo M.K., Sung Y.K., Cho C.S., and Lee Y.M. Effect of polymer complex formation on the cloud-point of poly(N-isopropyl acrylamide) (PNIPAAm) in the poly(NIPAAm-co-acrylic acid): polyelectrolyte complex between poly(acrylic acid) and poly(allylamine). Polymer 38 (1997) 2759-2765
32. Yoo M.K., Sung Y.K., Lee Y.M., and Cho C.S. Effect of polyelectrolyte on the lower critical solution temperature of poly(N-isopropyl acrylamide) in the poly(NIPAAm-co-acrylic acid) hydrogel. Polymer 41 (2000) 5713-5719
33. Aoyagi T., Ebara M., Sakai K., Sakurai Y., and Okano T. Novel bifunctional polymer with reactivity and temperature sensitivity. J. Biomater. Sci.: Polym. Edn. 11 (2000) 101-110
34. Ebara M., Aoyagi T., Sakai K., and Okano T. Introducing reactive carboxyl side chains retains phase transition temperature sensitivity in N-isopropylacrylamide copolymer gels. Macromolecules 33 (2000) 8312-8316
35. Ebara M., Aoyagi T., Sakai K., and Okano T. The incorporation of carboxylate groups into temperature-responsive poly(N-isopropylacrylamide)-based hydrogels promotes rapid gel shrinking. J. Polym. Sci. Part A: Polym. Chem. 39 (2001) 335-342
36. Zhang X.Z., Wu D.Q., and Chu C.C. Effect of crosslinking level on the properties of temperature-sensitive poly(N-isopropylacylamide) hydrogels. J. Polym. Sci. Part B: Polym. Phys. 41 (2003) 582-593
37. Xu X.D., Zhang X.Z., Cheng S.X., and Zhuo R.X. Fabrication of novel temperature and pH sensitive poly(N-isopropylmaleamic acid-co-acrylonitrile) hydrogels. Colloid Polym. Sci. 285 (2006) 75-82
38. Xu X.D., Zhang X.Z., Cheng S.X., Zhuo R.X., and Kennedy J.F. A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity. Carbohyd. Polym. 68 (2007) 416-423
39. Harmon M.E., Kuckling D., and Frank C.W. Photo-cross-linkable PNIPAAm copolymers. 2. Effects of constraint on temperature and pH-responsive hydrogel layers. Macromolecules 36 (2003) 162-172
40. Reschel T., Konak C., Oupicky D., Seymour L.W., and Ulbrich K. Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations. J. Control. Rel. 81 (2002) 201-217
41. Xu X.D., Zhang X.Z., Wang B., Cheng S.X., Zhuo R.X., and Wang Z.C. Fabrication of a novel temperature sensitive poly (N-isopropyl-3-butenamide) hydrogel. Colloid Surf. B: Biointerf. 59 (2007) 158-163
42. Zhang X.Z., Wu D.Q., and Chu C.C. Synthesis and characterization of partially biodegradable, temperature and pH sensitive Dex-MA/PNIPAAm hydrogels. Biomaterials 25 (2004) 4719-4730
43. Li Y., and Tanaka T. Kinetics of swelling and shrinking of gels. J. Chem. Phys. 92 (1990) 1365-1368
44. Wu C., and Pan C.Y. Studies of the swelling and drying kinetics of thin gelatin gel films by in situ interferometry. Macromolecules 27 (1994) 4516-4520
45. a of MAA comonomeric units. Polym. Int. 52 (2003) 956-965