Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators

Phytochemistry

Volumn 96, Issue , 2013, Pages 318-329

  Schramm, Anja ^a   Ebrahimi, Samad Nejad ^a,b   Raith, Melanie ^a   Zaugg, Janine ^a   Rueda, Diana C ^a   Hering, Steffen ^c   Hamburger, Matthias ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SHAHID BEHESHTI UNIVERSITY   (Iran)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Curcuma kwangsiensis; Electronic circular dichroism (ECD); GABAA receptor modulation; HPLC based activity profiling; Labdane diterpenoids; Xenopus oocyte assay; Zingiberaceae

Indexed keywords

CURCUMA; CURCUMA KWANGSIENSIS; XENOPUS LAEVIS; ZINGIBERACEAE;

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; DITERPENE; HERBACEOUS AGENT; LABDANE;

ANIMAL; ARTICLE; CE; CHEMISTRY; CHINESE MEDICINE; CONDUCTOR-LIKE POLARIZABLE CONTINUUM MODEL; COTTON EFFECT; CPCM; CURCUMA; CURCUMA KWANGSIENSIS; DRUG EFFECT; ECD; ELECTRONIC CIRCULAR DICHROISM; ELECTRONIC CIRCULAR DICHROISM (ECD); GABA(A) RECEPTOR MODULATION; GABA-INDUCED CHLORIDE CURRENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC-BASED ACTIVITY PROFILING; I(GABA); ISOLATION AND PURIFICATION; LABDANE DITERPENOIDS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; OOCYTE; OPLS; OPTIMIZED POTENTIAL FOR LIQUID SIMULATIONS; PRENATAL DEVELOPMENT; RHIZOME; SCRF; SELF-CONSISTENT REACTION FIELD; TCM; TDDFT; TIME-DEPENDENT DENSITY FUNCTION THEORY; XENOPUS; XENOPUS OOCYTE ASSAY; ZINGIBERACEAE;

CE; CONDUCTOR-LIKE POLARIZABLE CONTINUUM MODEL; COTTON EFFECT; CPCM; CURCUMA KWANGSIENSIS; ECD; ELECTRONIC CIRCULAR DICHROISM; ELECTRONIC CIRCULAR DICHROISM (ECD); GABA; GABA(A) RECEPTOR MODULATION; GABA-INDUCED CHLORIDE CURRENT; GAMMA-AMINOBUTYRIC ACID; HPLC-BASED ACTIVITY PROFILING; I(GABA); LABDANE DITERPENOIDS; OPLS; OPTIMIZED POTENTIAL FOR LIQUID SIMULATIONS; SCRF; SELF-CONSISTENT REACTION FIELD; TCM; TDDFT; TIME-DEPENDENT DENSITY FUNCTION THEORY; TRADITIONAL CHINESE MEDICINE; XENOPUS OOCYTE ASSAY; ZINGIBERACEAE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMA; DITERPENES; DRUGS, CHINESE HERBAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OOCYTES; RECEPTORS, GABA-A; RHIZOME; XENOPUS;

EID: 84888357019     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2013.08.004     Document Type: Article

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