Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis

Inflammatory Bowel Diseases

Volumn 19, Issue 12, 2013, Pages 2593-2602

  Salk, Jesse J ^a   Bansal, Aasthaa ^a   Lai, Lisa A ^a   Crispin, David A ^a   Ussakli, Cigdem H ^a   Horwitz, Marshall S ^a   Bronner, Mary P ^b   Brentnall, Teresa A ^a   Loeb, Lawrence A ^a   Rabinovitch, Peter S ^a,c   Risques, Rosa Ana ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c USA   (United States)

Author keywords

Age of onset; Cancer biomarker; Field effect; Inflammatory bowel disease; Preneoplasia

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLONE; COLON BIOPSY; COLON RESECTION; DESCENDING COLON; FEMALE; GASTROINTESTINAL DYSPLASIA; GENOTYPE; HISTOPATHOLOGY; HUMAN; MALE; NEOPLASM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TELOMERE SHORTENING; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CLONE CELLS; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MUTATION; POLY G; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; PROGNOSIS; TELOMERE; YOUNG ADULT;

EID: 84888351649     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e3182a87640     Document Type: Article

References (30)

1. Kappelman MD, Moore KR, Allen JK, et al. Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population. Dig Dis Sci. 2013;58:519-525.
2. Hou JK, Kramer JR, Richardson P, et al. The incidence and prevalence of inflammatory bowel disease among U.S. veterans: a national cohort study. Inflamm Bowel Dis. 2013;19:1059-1064.
3. Jess T, Simonsen J, Jorgensen KT, et al. Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years. Gastroenterology. 2012;143:375-381 e371; quiz e313-374.
4. Lutgens MW, van Oijen MG, van der Heijden GJ, et al. Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies. Inflamm Bowel Dis. 2013;19:789-799.
5. Charpentier C, Salleron J, Savoye G, et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2013.
6. Ha CY, Newberry RD, Stone CD, et al. Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset disease. Clin Gastroenterol Hepatol. 2010;8:682-687 e681.
7. Baars JE, Kuipers EJ, van Haastert M, et al. Age at diagnosis of inflammatory bowel disease influences early development of colorectal cancer in inflammatory bowel disease patients: a nationwide, long-term survey. J Gastroenterol. 2012;47:1308-1322.
8. Brackmann S, Andersen SN, Aamodt G, et al. Two distinct groups of colorectal cancer in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:9-16.
9. Brentnall TA. Molecular underpinnings of cancer in ulcerative colitis. Curr Opin Gastroenterol. 2003;19:64-68.
10. Ullman T, Odze R, Farraye FA. Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohn's disease of the colon. Inflamm Bowel Dis. 2009;15:630-638.
11. Salk JJ, Salipante SJ, Risques RA, et al. Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci U S A. 2009; 106:20871-20876.
12. Boyer JC, Yamada NA, Roques CN, et al. Sequence dependent instability of mononucleotide microsatellites in cultured mismatch repair proficient and deficient mammalian cells. Hum Mol Genet. 2002;11:707-713.
13. Braakhuis BJ, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63:1727-1730.
14. Brentnall TA, Crispin DA, Rabinovitch PS, et al. Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroenterology. 1994;107:369-378.
15. Burmer GC, Rabinovitch PS, Haggitt RC, et al. Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology. 1992;103:1602-1610.
16. Rabinovitch PS, Dziadon S, Brentnall TA, et al. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 1999;59:5148-5153.
17. Risques RA, Lai LA, Himmetoglu C, et al. Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res. 2011;71:1669-1679.
18. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27:339-344.
19. Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007;130:223-233.
20. O'Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32: 280-284.
21. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
22. Janes H, Pepe MS. Adjusting for covariates in studies of diagnostic, screening, or prognostic markers: an old concept in a new setting. Am J Epidemiol. 2008;168:89-97.
23. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526-535.
24. Vijg J, Suh Y. Genome instability and aging. Annu Rev Physiol. 2013;75: 645-668.
25. Salk JJ, Horwitz MS. Passenger mutations as a marker of clonal cell lineages in emerging neoplasia. Semin Cancer Biol. 2010;20:294-303.
26. Murphy G, Devesa SS, Cross AJ, et al. Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer. 2011;128: 1668-1675.
27. O'Sullivan J, Risques RA, Mandelson MT, et al. Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2006;15:573-577.
28. Baker AM, Graham TA, Wright NA. Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development. J Pathol. 2013;229: 502-514.
29. Hiatt JB, Pritchard CC, Salipante SJ, et al. Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation. Genome Res. 2013;23:843-854.
30. Schmitt MW, Kennedy SR, Salk JJ, et al. Detection of ultra-rare mutations by next-generation sequencing. Proc Natl Acad Sci U S A. 2012;109: 14508-14513.