Molecular underpinnings of cancer in ulcerative colitis

Current Opinion in Gastroenterology

Volumn 19, Issue 1, 2003, Pages 64-68

  Brentnall, Teresa A ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHROMOSOME BREAKAGE; COLON CANCER; DISEASE DURATION; DNA FINGERPRINTING; DYSPLASIA; FLUORESCENCE IN SITU HYBRIDIZATION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; PHENOTYPE; REVIEW; TELOMERE; ULCERATIVE COLITIS;

EID: 0037215289     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-200301000-00011     Document Type: Review

References (25)

1. Burmer GC, Rabinovitch PS, Haggitt RC, et al.: Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele. Gastroenterology 1992, 103:1602-1610.
2. Levine DS, Rabinovitch PS, Haggitt RC, et al.: Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer. Gastroenterology 1991, 101:1198-1210.
3. Lofberg R, Brostrom O, Karlen P, et al.: DNA aneuploidy in ulcerative colitis: Reproducibility, topographic distribution, and relation to dysplasia. Gastroenterology 1992, 102:1149-1154.
4. Brentnall TA, Crispin DA, Rabinovitch PS, et al.: Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis. Gastroenterology 1994, 107:369-378.
5. Brentnall TA: Risk Factors for Development of Colorectal Cancer in Inflammatory Bowel Disease: Advances in Inflammatory Bowel Disease. Norwell, MA: Kluwer Academic Publishers; 1998:159-167.
6. Willenbucher RF, Zelman SJ, Ferrell LD, et al.: Chromosomal alterations in ulcerative colitis-related neoplastic progression. Gastroenterology 1997, 113:791-801.
7. Kern SE, Redston M, Seymour AB, et al.: Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology 1994, 107:420-428.
8. Yin J, Harpaz N, Tong Y, et al.: p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 1993, 104:1633-1639.
9. Redston MS, Papadopoulos N, Caldas C, et al.: Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias. Gastroenterology 1995, 108:383-392.
10. Tarmin L, Yin J, Harpaz N, et al.: Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res 1995, 55:2035-2038.
11. Wersto RP, Greenebaum E, Deitch D, et al.: Deoxyribonucleic acid ploidy and cell cycle events in benign colonic epithelium peripheral to carcinoma. Lab Invest 1988, 58:218-225.
12. Rabinovitch PS, Dziadon A, Brentnall TA, et al.: Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res 1999, 59:5148-5153.
13. Brentnall TA, Crispin DA, Bronner MP, et al.: Microsatellite instability is present in non-neoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 1996, 56:1237-1240.
14. Cravo ML, Albuquerque CM, Salezar de Sousa L, et al.: Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: Effect of folate supplementation. Am J Gastroenterol 1998, 93:2060-2064.
15. Park WS, Pham T, Wang C, et al.: Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis. Int J Mol Med 1998, 2:221-224.
16. Heinen CD, Noffsinger AE, Belli J, et al.: Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation. Genes Chromosomes Cancer 1997, 19:170-175.
17. Loeb LA: Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991, 51:3075-3079.
18. Jackson AL, Chen R, Loeb LA: Induction of microsatellite instability by oxidative DNA damage. Proc Natl Acad Sci U S A 1998, 95(21):12468-12473.
19. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al.: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996, 111:307-317.
20. Welsh J, Rampino N, McClelland M, Perucho M: Nucleic acid fingerprinting by PCR-based methods: Applications to problems in aging and mutagenesis. Mut Res 1995, 338:215-229.
21. Chen R, Rabinovitch PS, Crispin DA, et al.: DNA fingerprinting abnormalities can distinguish UC patients with dysplasia and cancer from those who are dysplasia/cancer free. Am J Pathol 2002, in press.
22. O'Sullivan JN, Bronner MP, Brentnall TA, et al.: Chromosomal instability is related to telomere shortening in a human preneoplastic disease (ulcerative colitis). Nat Genet 2002, 32:280-284.
23. Kohonen-Corish MR, Daniel JJ, te Riele H, et al.: The susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. Cancer Res 2002, 62:2092-2097.
24. Cottliar A, Fundia A, Boerr L, et al.: High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis. Am J Gastroenterol 2000, 95:2301-2307.
25. Sanford KK, Price FM, Brodeur C, et al.: Deficient DNA repair in chronic ulcerative colitis. Cancer Detect Prev 1997, 21:540-545.