Impaired cerebral blood flow autoregulation during posttraumatic arterial hypotension after fluid percussion brain injury is prevented by phenylephrine in female but exacerbated in male piglets by extracellular signal-related kinase mitogen-activated protein kinase upregulation

Critical Care Medicine

Volumn 38, Issue 9, 2010, Pages 1868-1874

  Armstead, William M ^a   Kiessling, J Willis ^a   Kofke, W Andrew ^a   Vavilala, Monica S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

autoregulation; cerebral circulation; pediatric; signal transduction; traumatic brain injury

Indexed keywords

ADRENOMEDULLIN; MITOGEN ACTIVATED PROTEIN KINASE; PAPAVERINE; PHENYLEPHRINE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; AUTOREGULATION; BLOOD CHEMISTRY; BRAIN BLOOD FLOW; BRAIN PERFUSION; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; HEMORRHAGIC HYPOTENSION; INTRACRANIAL PRESSURE; MALE; NEWBORN; NONHUMAN; PERFUSION PRESSURE; PIA ARTERY; PRIORITY JOURNAL; SEX DIFFERENCE; SWINE; TRAUMATIC BRAIN INJURY; UPREGULATION; VASOCONSTRICTION; VASODILATATION; ANIMAL; BRAIN CIRCULATION; BRAIN INJURY; CEREBROSPINAL FLUID; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; HYPOTENSION; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROSPECTIVE STUDY;

ADRENOMEDULLIN; ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; CEREBROVASCULAR CIRCULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HYPOTENSION; MALE; PHENYLEPHRINE; PHOSPHORYLATION; PROSPECTIVE STUDIES; SEX FACTORS; SWINE; UP-REGULATION; VASOCONSTRICTOR AGENTS;

EID: 77956225072     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181e8ac1a     Document Type: Article

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