Remifentanil postconditioning improves global cerebral ischemia-induced spatial learning and memory deficit in rats via inhibition of neuronal apoptosis through the PI3K signaling pathway

Neurological Sciences

Volumn 34, Issue 11, 2013, Pages 1955-1962

  Hu, Xianwen ^a   Xie, Chunlin ^a   He, Shufang ^a   Zhang, Ye ^a   Li, Yun ^a   Jiang, Lingling ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Global cerebral ischemia; Neuronal apoptosis; Phosphoinositide 3 kinase; Remifentanil postconditioning; Spatial learning and memory

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REMIFENTANIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; ISCHEMIC POSTCONDITIONING; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPATIAL LEARNING;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84888308323     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-013-1419-4     Document Type: Article

References (34)

1. Liang HW, Qiu SF, Shen J et al (2008) Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. Neurosci Lett 438:116-120
2. Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. Stroke 39:983-990
3. Ren C, Yan Z, Wei D et al (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res 1288:88-94
4. Alkan T (2009) Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning. Turk Neurosurg 19:406-412
5. Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. Int J Mol Sci 13:6089-6101
6. Zhou Y, Fathali N, Lekic T et al (2012) Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. Stroke 42:439-444
7. Pateliya BB, Singh N, Jaggi AS (2008) Possible role of opioids and KATP channels in neuroprotective effect of postconditioning in mice. Biol Pharm Bull 31:1755-1760
8. Danielisova V, Gottlieb M, Nemethova M et al (2009) Bradykinin postconditioning protects pyramidal CA1 neurons against delayed neuronal death in rat hippocampus. Cell Mol Neurobiol 29:871-878
9. Chen TY, Goyagi T, Toung TJ et al (2004) Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats. Stroke 35:1180-1185
10. Charron C, Messier C, Plamondon H (2008) Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia. Physiol Behav 93:502-511
11. Zhang Y, Irwin MG, Wong TM (2004) Remifentanil preconditioning protects against ischemic injury in the intact rat heart. Anesthesiology 101:918-923
12. Zhang Y, Chen ZW, Girwin M et al (2005) Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. Acta Pharmacol Sin 26:546-550
13. Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. J Neurosurg Anesthesiol 24:51-57
14. Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. Brain Res 1367:85-93
15. Prasad SS, Russell M, Nowakowska M (2011) Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways. J Mol Neurosci 43:428-442
16. Wang JK, Yu LN, Zhang FJ et al (2010) Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway. Brain Res 1357:142-151
17. Tegeder I, Geisslinger G (2004) Opioids as modulators of cell death and survival-unraveling mechanisms and revealing new indications. Pharmacol Rev 56:351-369
18. Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60
19. Peng B, Guo QL, He ZJ et al (2012) Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway. Brain Res 1445:92-102
20. Zhang Y, Irwin MG, Wong TM et al (2005) Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology 102:371-378
21. Wong GT, Li R, Jiang LL et al (2010) Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via kappa or delta opioid receptor activation. Acta Anaesthesiol Scand 54:510-518
22. Park SW, Yi JW, Kim YM et al (2011) Remifentanil alleviates transient cerebral ischemia-induced memory impairment through suppression of apoptotic neuronal cell death in gerbils. Korean J Anesthesiol 61:63-68
23. Cheng O, Li Z, Han Y et al (2012) Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis. Brain Res 1470:111-118
24. Broughton BR, Reutens DC, Sobey CG (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40:e331-e339
25. Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219
26. Metrailler-Ruchonnet I, Pagano A, Carnesecchi S et al (2007) Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway. Free Radic Biol Med 42:1062-1074
27. Kim HS, Cho JE, Hong SW et al (2010) Remifentanil protects myocardium through activation of anti-apoptotic pathways of survival in ischemia-reperfused rat heart. Physiol Res 59:347-356
28. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657
29. Cui D, Wang L, Qi A et al (2002) Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS One 7:e35324
30. Wang HY, Wang GL, Yu YH et al (2009) The role of phosphoinositide-3- kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res 1297:177-184
31. Zhou Y, Lekic T, Fathali N et al (2010) Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine- 1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. Stroke 41:1521-1527
32. Ye Z, Guo Q, Xia P et al (2012) Sevoflurane postconditioning involves an up-regulation of HIF-1alpha and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia. Brain Res 1463:63-74
33. Xu X, Chua CC, Gao J et al (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res 1227:12-18
34. Yao RQ, Qi DS, Yu HL et al (2012) Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res 37:2777-2786