Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia

Brain Research

Volumn 1463, Issue , 2012, Pages 63-74

  Ye, Zhi ^a   Guo, Qulian ^a   Xia, Pingping ^a   Wang, Na ^a   Wang, E ^a   Yuan, Yajing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion injury; Heme oxygenase 1 (HO 1); Hypoxia inducible factor 1 (HIF 1 ); Neuroprotection; Phosphatidylinositol 3 kinase (PI3K) Akt; Sevoflurane postconditioning

Indexed keywords

CASPASE 3; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SEVOFLURANE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVITY; GENE EXPRESSION; ISCHEMIC POSTCONDITIONING; MALE; NERVE INJURY; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION;

ANDROSTADIENES; ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIC POSTCONDITIONING; MALE; METHYL ETHERS; NEURAL PATHWAYS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

RATTUS;

EID: 84861840455     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.04.050     Document Type: Article

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