GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion

Biochemical and Biophysical Research Communications

Volumn 441, Issue 3, 2013, Pages 643-648

  Soni, Arvind ^a   Amisten, Stefan ^b   Rorsman, Patrik ^b   Salehi, Albert ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cell viability; Diabetes; Endocrinology; Insulin secretion; Pancreatic islet

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 5B; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MESSENGER RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CLONE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

MURINAE; MUS;

ADULT; AGED; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; FEMALE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MIDDLE AGED; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GLUTAMATE;

EID: 84888308286     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.099     Document Type: Article

References (22)

1. Bensellam M., Laybutt D.R., Jonas J.C. The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions. Mol. Cell Endocrinol. 2012, 364:1-27.
2. Bensellam M., Van Lommel L., Overbergh L., Schuit F.C., Jonas J.C. Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations. Diabetologia 2009, 52:463-476.
3. Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11:98-107.
4. Eizirik D.L., Colli M.L., Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat. Rev. Endocrinol. 2009, 5:219-226.
5. Taneera J., Lang S., Sharma A., Fadista J., Zhou Y., Ahlqvist E., Jonsson A., Lyssenko V., Vikman P., Hansson O., Parikh H., Korsgren O., Soni A., Krus U., Zhang E., Jing X.J., Esguerra J.L., Wollheim C.B., Salehi A., Rosengren A., Renstrom E., Groop L. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab. 2012, 16:122-134.
6. Amisten S., Salehi A., Rorsman P., Jones P.M., Persaud S.J. An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacol. Ther. 2013, 139:359-391.
7. Cheng Y., Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 1998, 273:35008-35015.
8. Robbins M.J., Michalovich D., Hill J., Calver A.R., Medhurst A.D., Gloger I., Sims M., Middlemiss D.N., Pangalos M.N. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors. Genomics 2000, 67:8-18.
9. Brauner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B., Krogsgaard-Larsen P., O'Hara P. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim. Biophys. Acta 2001, 1518:237-248.
10. P. Joost, A. Methner, Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands, Genome Biol 3 (2002) RESEARCH0063.
11. Speliotes E.K., Willer C.J., Berndt S.I., Monda K.L., Thorleifsson G., Jackson A.U., Lango Allen H., Lindgren C.M., Luan J., Magi R., Randall J.C., Vedantam S., Winkler T.W., Qi L., Workalemahu T., Heid I.M., Steinthorsdottir V., Stringham H.M., Weedon M.N., Wheeler E., Wood A.R., Ferreira T., Weyant R.J., Segre A.V., Estrada K., Liang L., Nemesh J., Park J.H., Gustafsson S., Kilpelainen T.O., Yang J., Bouatia-Naji N., Esko T., Feitosa M.F., Kutalik Z., Mangino M., Raychaudhuri S., Scherag A., Smith A.V., Welch R., Zhao J.H., Aben K.K., Absher D.M., Amin N., Dixon A.L., Fisher E., Glazer N.L., Goddard M.E., Heard-Costa N.L., Hoesel V., Hottenga J.J., Johansson A., Johnson T., Ketkar S., Lamina C., Li S., Moffatt M.F., Myers R.H., Narisu N., Perry J.R., Peters M.J., Preuss M., Ripatti S., Rivadeneira F., Sandholt C., Scott L.J., Timpson N.J., Tyrer J.P., van Wingerden S., Watanabe R.M., White C.C., Wiklund F., Barlassina C., Chasman D.I., Cooper M.N., Jansson J.O., Lawrence R.W., Pellikka N., Prokopenko I., Shi J., Thiering E., Alavere H., Alibrandi M.T., Almgren P., Arnold A.M., Aspelund T., Atwood L.D., Balkau B., Balmforth A.J., Bennett A.J., Ben-Shlomo Y., Bergman R.N., Bergmann S., Biebermann H., Blakemore A.I., Boes T., Bonnycastle L.L., Bornstein S.R., Brown M.J., Buchanan T.A., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 2010, 42:937-948.
12. Lee M. Neurotransmitters and microglial-mediated neuroinflammation. Curr. Protein Pept. Sci. 2013, 14:21-32.
13. Meidute Abaraviciene S., Muhammed S.J., Amisten S., Lundquist I., Salehi A. GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats. Mol. Cell Endocrinol. 2013, 381:150-159.
14. Salehi A., Flodgren E., Nilsson N.E., Jimenez-Feltstrom J., Miyazaki J., Owman C., Olde B. Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Cell Tissue Res. 2005, 322:207-215.
15. Balhuizen A., Kumar R., Amisten S., Lundquist I., Salehi A. Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol. Cell Endocrinol. 2010, 320:16-24.
16. Weir G.C., Bonner-Weir S. Islet beta cell mass in diabetes and how it relates to function, birth, and death. Ann. NY Acad. Sci. 2013, 1281:92-105.
17. Y.J. Kim, T. Sano, T. Nabetani, Y. Asano, Y. Hirabayashi, GPRC5B activates obesity-associated inflammatory signaling in adipocytes, Sci. Signal. 5 (2012) ra85.
18. Gammelsaeter R., Coppola T., Marcaggi P., Storm-Mathisen J., Chaudhry F.A., Attwell D., Regazzi R., Gundersen V. A role for glutamate transporters in the regulation of insulin secretion. PLoS One 2011, 6:e22960.
19. Gopel S., Zhang Q., Eliasson L., Ma X.S., Galvanovskis J., Kanno T., Salehi A., Rorsman P. Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J. Physiol. 2004, 556:711-726.
20. Maechler P., Wollheim C.B. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 1999, 402:685-689.
21. Costes S., Langen R., Gurlo T., Matveyenko A.V., Butler P.C. Beta-Cell failure in type 2 diabetes: a case of asking too much of too few?. Diabetes 2013, 62:327-335.
22. Lee Y.H., Pratley R.E. The evolving role of inflammation in obesity and the metabolic syndrome. Curr. Diab. Rep. 2005, 5:70-75.