-
1
-
-
84883321452
-
Signaling pathways mediating epithelial-mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ
-
Grippo PJ, Munshi HG (eds). Transworld Research Network,Trivandrum, India, Chapter 7
-
Bailey JM, Leach SD (2012) Signaling pathways mediating epithelial-mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ. In: Grippo PJ, Munshi HG (eds) Pancreatic cancer and tumor microenvironment. Transworld Research Network,Trivandrum, India, Chapter 7
-
(2012)
Pancreatic Cancer and Tumor Microenvironment
-
-
Bailey, J.M.1
Leach, S.D.2
-
2
-
-
67649623162
-
Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells
-
19468255 1:CAS:528:DC%2BD1MXmtlCgtro%3D 10.1159/000209393
-
Chen H, Chen X, Ye F, Lu W, Xie X (2009) Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells. Pathobiology 76(3):149-154
-
(2009)
Pathobiology
, vol.76
, Issue.3
, pp. 149-154
-
-
Chen, H.1
Chen, X.2
Ye, F.3
Lu, W.4
Xie, X.5
-
3
-
-
33751503224
-
Numb is a suppressor of Hedgehog signaling and targets Numb for Itch-dependent ubiquitination
-
17115028 10.1038/ncb1510
-
Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A (2006) Numb is a suppressor of Hedgehog signaling and targets Numb for Itch-dependent ubiquitination. Nat Cell Biol 8(12):1415-1423
-
(2006)
Nat Cell Biol
, vol.8
, Issue.12
, pp. 1415-1423
-
-
Di Marcotullio, L.1
Ferretti, E.2
Greco, A.3
De Smaele, E.4
Po, A.5
Sico, M.A.6
Alimandi, M.7
Giannini, G.8
Maroder, M.9
Screpanti, I.10
Gulino, A.11
-
4
-
-
0037311096
-
P53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer
-
12561067 1:CAS:528:DC%2BD3sXhs1ynsbo%3D 10.1002/jso.10186
-
Dong M, Nio Y, Yamasawa K, Toga T, Yue L, Harada T (2003) p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer. J Surg Oncol 82(2):111-120
-
(2003)
J Surg Oncol
, vol.82
, Issue.2
, pp. 111-120
-
-
Dong, M.1
Nio, Y.2
Yamasawa, K.3
Toga, T.4
Yue, L.5
Harada, T.6
-
5
-
-
82555169796
-
NUMB does not impair growth and differentiation status of experimental gliomas
-
21939656 1:CAS:528:DC%2BC3MXhsVOjtL%2FJ 10.1016/j.yexcr.2011.09.002
-
Euskirchen P, Skaftnesmo KO, Huszthy PC, Brekkå N, Bjerkvig R, Jacobs AH, Miletic H (2011) NUMB does not impair growth and differentiation status of experimental gliomas. Exp Cell Res 317(20):2864-2873
-
(2011)
Exp Cell Res
, vol.317
, Issue.20
, pp. 2864-2873
-
-
Euskirchen, P.1
Skaftnesmo, K.O.2
Huszthy, P.C.3
Brekkå, N.4
Bjerkvig, R.5
Jacobs, A.H.6
Miletic, H.7
-
6
-
-
77649183954
-
The multiple functions of Numb
-
19944684 1:CAS:528:DC%2BC3cXivFKgtbY%3D 10.1016/j.yexcr.2009.11.017
-
Gulino A, Di Marcotullio L, Screpanti I (2010) The multiple functions of Numb. Exp Cell Res 316(6):900-906
-
(2010)
Exp Cell Res
, vol.316
, Issue.6
, pp. 900-906
-
-
Gulino, A.1
Di Marcotullio, L.2
Screpanti, I.3
-
7
-
-
80053312388
-
Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling
-
21893032 1:CAS:528:DC%2BC3MXht1GkurzP 10.1016/j.bbrc.2011.08.108
-
Liu L, Lanner F, Lendahl U, Das D (2011) Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling. Biochem Biophys Res Commun 413(3):426-431
-
(2011)
Biochem Biophys Res Commun
, vol.413
, Issue.3
, pp. 426-431
-
-
Liu, L.1
Lanner, F.2
Lendahl, U.3
Das, D.4
-
8
-
-
37749020569
-
Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas
-
18179751 1:CAS:528:DC%2BD1cXht1ahsb8%3D
-
Maiorano E, Favia G, Pece S, Resta L, Maisonneuve P, Di Fiore PP, Capodiferro S, Urbani U, Viale G (2007) Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas. Int J Immunopathol Pharmacol 20(4):779-789
-
(2007)
Int J Immunopathol Pharmacol
, vol.20
, Issue.4
, pp. 779-789
-
-
Maiorano, E.1
Favia, G.2
Pece, S.3
Resta, L.4
Maisonneuve, P.5
Di Fiore, P.P.6
Capodiferro, S.7
Urbani, U.8
Viale, G.9
-
9
-
-
0033761153
-
Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients
-
11051257 1:CAS:528:DC%2BD3cXotVyku7w%3D
-
Masunaga R, Kohno H, Dhar DK, Ohno S, Shibakita M, Kinugasa S, Yoshimura H, Tachibana M, Kubota H, Nagasue N (2000) Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. Clin Cancer Res 6(10):4064-4068
-
(2000)
Clin Cancer Res
, vol.6
, Issue.10
, pp. 4064-4068
-
-
Masunaga, R.1
Kohno, H.2
Dhar, D.K.3
Ohno, S.4
Shibakita, M.5
Kinugasa, S.6
Yoshimura, H.7
Tachibana, M.8
Kubota, H.9
Nagasue, N.10
-
10
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
12507556 1:CAS:528:DC%2BD38XpvVWksrw%3D 10.1016/S1044-579X(02)00099-8
-
Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13(1):49-58
-
(2003)
Semin Cancer Biol
, vol.13
, Issue.1
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
11
-
-
15244362062
-
P53 abnormalities and outcomes in colorectal cancer: A systematic review
-
15668707 1:CAS:528:DC%2BD2MXhtFWntr0%3D
-
Munro AJ, Lain S, Lane DP (2005) P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 92(3):434-444
-
(2005)
Br J Cancer
, vol.92
, Issue.3
, pp. 434-444
-
-
Munro, A.J.1
Lain, S.2
Lane, D.P.3
-
12
-
-
84860227858
-
Radiofrequency ablation of liver metastasis in patients with locally controlled pancreatic ductal adenocarcinoma
-
22525021 10.1016/j.jvir.2012.01.080
-
Park JB, Kim YH, Kim J et al (2012) Radiofrequency ablation of liver metastasis in patients with locally controlled pancreatic ductal adenocarcinoma. J Vasc Interv Radiol 23(5):635-641
-
(2012)
J Vasc Interv Radiol
, vol.23
, Issue.5
, pp. 635-641
-
-
Park, J.B.1
Kim, Y.H.2
Kim, J.3
-
13
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
15492044 1:CAS:528:DC%2BD2cXptVKqt7Y%3D 10.1083/jcb.200406140
-
Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP (2004) Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167(2):215-221
-
(2004)
J Cell Biol
, vol.167
, Issue.2
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
Capra, M.4
Hulleman, E.5
Galimberti, V.6
Zurrida, S.7
Maisonneuve, P.8
Viale, G.9
Di Fiore, P.P.10
-
14
-
-
0031746179
-
The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma
-
9645455 1:CAS:528:DyaK1cXlslOisLo%3D 10.1007/s004320050162
-
Qiu SJ, Ye SL, Wu ZQ, Tang ZY, Liu YK (1998) The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma. J Cancer Res Clin Oncol 124(5):253-258
-
(1998)
J Cancer Res Clin Oncol
, vol.124
, Issue.5
, pp. 253-258
-
-
Qiu, S.J.1
Ye, S.L.2
Wu, Z.Q.3
Tang, Z.Y.4
Liu, Y.K.5
-
15
-
-
84859997937
-
MDM2 protein-mediated ubiquitination of numb protein: Identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism
-
22337874 1:CAS:528:DC%2BC38XlvVGltLw%3D 10.1074/jbc.M111.303875
-
Sczaniecka M, Gladstone K, Pettersson S, McLaren L, Huart AS, Wallace M (2012) MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism. J Biol Chem 287(17):14052-14068
-
(2012)
J Biol Chem
, vol.287
, Issue.17
, pp. 14052-14068
-
-
Sczaniecka, M.1
Gladstone, K.2
Pettersson, S.3
McLaren, L.4
Huart, A.S.5
Wallace, M.6
-
16
-
-
0036801150
-
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts
-
12361975 1:CAS:528:DC%2BD38XosF2js7w%3D
-
Shen Q, Zhong W, Jan YN, Temple S (2002) Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 129(20):4843-4853
-
(2002)
Development
, vol.129
, Issue.20
, pp. 4843-4853
-
-
Shen, Q.1
Zhong, W.2
Jan, Y.N.3
Temple, S.4
-
17
-
-
59649123344
-
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells
-
19029954 1:CAS:528:DC%2BD1cXhsVWhu77K 10.1038/onc.2008.423
-
Sui X, Shin S, Zhang R, Firozi PF, Yang L, Abbruzzese JL, Reddy SA (2009) Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells. Oncogene 28(5):709-720
-
(2009)
Oncogene
, vol.28
, Issue.5
, pp. 709-720
-
-
Sui, X.1
Shin, S.2
Zhang, R.3
Firozi, P.F.4
Yang, L.5
Abbruzzese, J.L.6
Reddy, S.A.7
-
18
-
-
0024980213
-
Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
-
2752427 1:CAS:528:DyaK3cXhvFartLk%3D 10.1016/0092-8674(89)90849-0
-
Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN (1989) Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58(2):349-360
-
(1989)
Cell
, vol.58
, Issue.2
, pp. 349-360
-
-
Uemura, T.1
Shepherd, S.2
Ackerman, L.3
Jan, L.Y.4
Jan, Y.N.5
-
19
-
-
0033621169
-
Distinct human NUMB isoforms regulate differentiation vs proliferation in the neuronal lineage
-
10468633 1:CAS:528:DyaK1MXlvFenu7s%3D 10.1073/pnas.96.18.10472
-
Verdi JM, Bashirullah A, Goldhawk DE et al (1999) Distinct human NUMB isoforms regulate differentiation vs.proliferation in the neuronal lineage. Proc Natl Acad Sci USA 96:10472-10476
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10472-10476
-
-
Verdi, J.M.1
Bashirullah, A.2
Goldhawk, D.E.3
-
20
-
-
78649503266
-
Two novel human NUMB isoforms provide a potential link between development and cancer
-
21122105 10.1186/1749-8104-5-31
-
Verdi JM, Bashirullah A, Goldhawk DE, Kubu CJ, Jamali M, Meakin SO, Lipshitz HD (2010) Two novel human NUMB isoforms provide a potential link between development and cancer. Neural Dev 5:31
-
(2010)
Neural Dev
, vol.5
, pp. 31
-
-
Verdi, J.M.1
Bashirullah, A.2
Goldhawk, D.E.3
Kubu, C.J.4
Jamali, M.5
Meakin, S.O.6
Lipshitz, H.D.7
-
21
-
-
69249209681
-
Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signaling
-
19609305 1:CAS:528:DC%2BD1MXotlSgt7k%3D 10.1038/emboj.2009.190
-
Wang Z, Sandiford S, Wu C, Li SS (2009) Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signaling. EMBO J 28(16):2360-2373
-
(2009)
EMBO J
, vol.28
, Issue.16
, pp. 2360-2373
-
-
Wang, Z.1
Sandiford, S.2
Wu, C.3
Li, S.S.4
-
22
-
-
76049110053
-
Alterations of the Notch pathway in lung cancer
-
20007775 1:CAS:528:DC%2BC3cXmtlagsQ%3D%3D 10.1073/pnas.0907781106
-
Westhoff B, Colaluca IN, D'Ario G, Donzelli M, Tosoni D, Volorio S, Pelosi G, Spaggiari L, Mazzarol G, Viale G, Pece S, Di Fiore PP (2009) Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci USA 106(52):22293-22298
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.52
, pp. 22293-22298
-
-
Westhoff, B.1
Colaluca, I.N.2
D'Ario, G.3
Donzelli, M.4
Tosoni, D.5
Volorio, S.6
Pelosi, G.7
Spaggiari, L.8
Mazzarol, G.9
Viale, G.10
Pece, S.11
Di Fiore, P.P.12
-
23
-
-
0036023416
-
Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer
-
12171884 1:CAS:528:DC%2BD38XmvVahs78%3D
-
Yamasawa K, Nio Y, Dong M, Yamaguchi K, Itakura M (2002) Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer. Clin Cancer Res 8(8):2563-2569
-
(2002)
Clin Cancer Res
, vol.8
, Issue.8
, pp. 2563-2569
-
-
Yamasawa, K.1
Nio, Y.2
Dong, M.3
Yamaguchi, K.4
Itakura, M.5
-
24
-
-
49749111551
-
Characterization of Numb expression in astrocytomas
-
18384513 10.1111/j.1440-1789.2008.00907.x
-
Yan B, Omar FM, Das K, Ng WH, Lim C, Shiuan K, Yap CT, Salto-Tellez M (2008) Characterization of Numb expression in astrocytomas. Neuropathology 28(5):479-484
-
(2008)
Neuropathology
, vol.28
, Issue.5
, pp. 479-484
-
-
Yan, B.1
Omar, F.M.2
Das, K.3
Ng, W.H.4
Lim, C.5
Shiuan, K.6
Yap, C.T.7
Salto-Tellez, M.8
-
25
-
-
0037459201
-
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase
-
12646252 1:CAS:528:DC%2BD3sXhvFGqsL0%3D 10.1016/S0006-291X(03)00282-1
-
Yogosawa S, Miyauchi Y, Honda R et al (2003) Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun 302(4):869-872
-
(2003)
Biochem Biophys Res Commun
, vol.302
, Issue.4
, pp. 869-872
-
-
Yogosawa, S.1
Miyauchi, Y.2
Honda, R.3
-
26
-
-
38049046724
-
NUMB controls p53 tumour suppressor activity
-
10.1038/nature06412
-
Yogosawa S, Miyauchi Y, Honda R, Tanaka H, Yasuda H (2008) NUMB controls p53 tumour suppressor activity. Nature 451(7174):76-80
-
(2008)
Nature
, vol.451
, Issue.7174
, pp. 76-80
-
-
Yogosawa, S.1
Miyauchi, Y.2
Honda, R.3
Tanaka, H.4
Yasuda, H.5
-
27
-
-
0028670932
-
P53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness
-
7872670 1:STN:280:DyaK2M7nslGgsA%3D%3D
-
Yokoyama M, Yamanaka Y, Friess H, Buchler M, Korc M (1994) p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness. Anticancer Res 14(6B):2477-2483
-
(1994)
Anticancer Res
, vol.14
, Issue.6 B
, pp. 2477-2483
-
-
Yokoyama, M.1
Yamanaka, Y.2
Friess, H.3
Buchler, M.4
Korc, M.5
-
28
-
-
0242360766
-
Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas
-
14641329 1:CAS:528:DC%2BD3sXpvVOjs7c%3D 10.1046/j.1432-0436.2003.7108006. x
-
Yoshida T, Tokunaga A, Nakao K, Okano H (2003) Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation 71(8):486-495
-
(2003)
Differentiation
, vol.71
, Issue.8
, pp. 486-495
-
-
Yoshida, T.1
Tokunaga, A.2
Nakao, K.3
Okano, H.4
-
29
-
-
17444423293
-
Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer
-
Yoshida T, Tokunaga A, Nakao K, Okano H (2005) Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. World J Gastroenterol 11(14):2162-2165
-
(2005)
World J Gastroenterol
, vol.11
, Issue.14
, pp. 2162-2165
-
-
Yoshida, T.1
Tokunaga, A.2
Nakao, K.3
Okano, H.4
|