Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas

Differentiation

Volumn 71, Issue 8, 2003, Pages 486-495

  Yoshida, Tetsu ^a   Tokunaga, Akinori ^a,b   Nakao, Keiko ^a,b   Okano, Hideyuki ^a,b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Ngn3; nNumb; Notch signaling; Pancreas; Splicing isoforms

Indexed keywords

GENE PRODUCT; NEUROGENIN 3; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PROTEIN ANTIBODY; PROTEIN MNUMB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; DOWN REGULATION; ENDOCRINE CELL; EXOCRINE CELL; GENE; GENE EXPRESSION; GENE REPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREAS ISLET; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA SPLICING; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA; MAMMALIA;

EID: 0242360766     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-0436.2003.7108006.x     Document Type: Article

References (36)

1. Apelqvist, A., Li. H., Sommer, L., Beatus, P., Anderson, D.J., Honjo, T., Hrabe de Angelis, M., Lendahl, U. and Edlund, H. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400:877-881.
2. Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770-776.
3. Berdnik, D., Torok, T., Gonzalez-Gaitan, M. and Knoblich, J.A. (2002) The endocytic protein α-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell 3: 221-231.
4. Bonner-Weir, S., Taneja, M., Weir, G.C., Tatarkiewicz, K., Song, K.H., Sharma, A. and O'Neil, J.J. (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004.
5. Bouwens, L., Wang, R.N., De Blay, E., Pipeleers, D.G. and Kloppel, G. (1994) Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 43:1279-1283.
6. Cayouette, M. and Raff, M. (2003) The orientation of cell division influences cell-fate choice in the developing mammalian retina. Development 130:2329-2339.
7. Chiang, M.K. and Melton, D.A. (2003) Single-cell transcript analysis of pancreas development. Dev Cell 4:383-393.
8. Dho, S.E., French, M.B., Woods, S.A. and McGlade, C.J. (1999) Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem 274:33097-33104.
9. Edlund, H. (2001) Factors controlling pancreatic cell differentiation and function. Diabetologia 44:1071-1079.
10. Gradwohl, G., Dierich, A., LeMeur, M. and Guillemot, F. (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611.
11. Gu, G., Dubauskaite, J. and Melton, D.A. (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
12. Gu, G., Brown, J.R. and Melton, D.A. (2003) Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 120:35-43.
13. Guo, M., Jan, L.Y. and Jan, Y.N. (1996) Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17:27-41.
14. Guz, Y., Montminy, M.R., Stein, R., Leonard, J., Gamer, L.W., Wright, C.V. and Teitelman, G. (1995) Expression of murine STF-1, a putative insulin gene transcription factor, in βcells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11-18.
15. Heimberg, H., Bouwens, L., Heremans, Y., Van De Casteele, M., Lefebvre, V. and Pipeleers, D. (2000) Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. Diabetes 49:571-579.
16. Heremans, Y., Van De Casteele, M., In't Veld, P., Gradwohl, G., Serup, P., Madsen, O., Pipeleers, D. and Heimberg, H. (2002) Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 159:303-312.
17. Jensen, J., Heller, R.S., Funder-Nielsen, T., Pedersen, E.E., Lindsell, C., Weinmaster, G., Madsen, O.D. and Serup, P. (2000a) Independent development of pancreatic α-and β-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49:163-176.
18. Jensen, J., Pedersen, E.E., Galante, P., Hald, J., Heller, R.S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P. and Madsen, O.D. (2000b) Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44.
19. Juven-Gershon, T., Shifman, O., Unger, T., Elkeles, A., Haupt, Y. and Oren, M. (1998) The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol 18:3974-3982.
20. Krebs, L.T., Xue, Y., Norton, C.R., Shutter, J.R., Maguire, M., Sundberg, J.P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., Smith, G.H., Stark, K.L. and Gridley, T. (2000) Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 14:1343-1352.
21. Lammert, E., Brown, J. and Melton, D.A. (2000) Notch gene expression during pancreatic organogenesis. Mech Dev 94:199-203.
22. Lu, B., Jan, L. and Jan, Y.N. (2000) Control of cell divisions in the nervous system: symmetry and asymmetry. Annu Rev Neurosci 23:531-556.
23. Nie, J., McGill, M.A., Dermer, M., Dho, S.E., Wolting, C.D. and McGlade, C.J. (2002) LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J 21:93-102.
24. Pang, K., Mukonoweshuro, C. and Wong, G.G. (1994) β cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. Proc Natl Acad Sci USA 91:9559-9563.
25. Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N. and Zhong, W. (2002) Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419:929-934.
26. Schwitzgebel, V.M., Scheel, D.W., Conners, J.R., Kalamaras, J., Lee, J.E., Anderson, D.J., Sussel, L., Johnson, J.D. and German, M.S. (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533-3542.
27. Sestan, N., Artavanis-Tsakonas, S. and Rakic, P. (1999) Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286:741-746.
28. Slack, J.M. (1995) Developmental biology of the pancreas. Development 121:1569-1580.
29. Susini, L., Passer, B.J., Amzallag-Elbaz, N., Juven-Gershon, T., Prieur, S., Privat, N., Tuynder, M., Gendron, M.C., Israel, A., Amson, R., Oren, M. and Telerman, A. (2001) Siah-1 binds and regulates the function of Numb. Proc Natl Acad Sci USA 98:15067-15072.
30. Swenne, I. (1992) Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35:193-201.
31. Uemura, T., Shepherd, S., Ackerman, L., Jan, L.Y. and Jan, Y.N. (1989) numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58:349-360.
32. Verdi, J.M., Bashirullah, A., Goldhawk, D.E., Kubu, C.J., Jamali, M., Meakin, S.O. and Lipshitz, H.D. (1999) Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc Natl Acad Sci USA 96: 10472-10476.
33. Wakamatsu, Y., Maynard, T.M., Jones, S.U. and Weston, J.A. (1999) NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Neuron 23:71-81.
34. Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. and Jan, Y.N. (1996) Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17:43-53.
35. Zhong, W., Jiang, M.M., Weinmaster, G., Jan, L.Y. and Jan, Y.N. (1997) Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124:1887-1897.
36. Zilian, O., Saner, C., Hagedorn, L., Lee, H.Y., Sauberli, E., Suter, U., Sommer, L. and Aguet, M. (2001) Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol 11:494-501.