Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia

Psychiatry Research

Volumn 210, Issue 3, 2013, Pages 710-715

  Chung, Ming Shun ^a   Yang, Albert C ^b,c,d   Lin, Yu Chung ^a   Lin, Chieh Nan ^a   Chang, Fang Rong ^a   Shen, Shu hua ^a   Ouyang, Wen Chen ^a   Loh, El Wui ^e   Chiu, Hsien Jane ^d,f  

^a Jianan Mental Hospital   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f MIN SHENG GENERAL HOSPITAL   (Taiwan)

Author keywords

Autonomic dysregulation; Heart rate variability; Metabolic syndrome; Psychopathology; Schizophrenia

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; C REACTIVE PROTEIN; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; BODY MASS; COMORBIDITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE SEVERITY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; HEART DISEASE; HEART RATE VARIABILITY; HOLTER MONITORING; HUMAN; LABORATORY TEST; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; METABOLIC DISORDER; NEGATIVE SYNDROME; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RATING SCALE; SCHIZOPHRENIA; TRIACYLGLYCEROL BLOOD LEVEL; VAGUS REFLEX; AUTONOMIC NERVOUS SYSTEM; BLOOD; BLOOD PRESSURE; CASE CONTROL STUDY; ELECTROCARDIOGRAPHY; GLUCOSE BLOOD LEVEL; HEART RATE; METABOLIC SYNDROME X; METABOLISM; METABOLOME; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL; TAIWAN;

ADULT; AUTONOMIC NERVOUS SYSTEM; BLOOD GLUCOSE; BLOOD PRESSURE; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; LINEAR MODELS; LIPOPROTEINS, HDL; MALE; METABOLIC SYNDROME X; METABOLOME; MIDDLE AGED; PSYCHOPATHOLOGY; SCHIZOPHRENIA; TAIWAN; TRIGLYCERIDES;

EID: 84888294811     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.07.034     Document Type: Article

References (63)

1. Akselrod S., Gordon D., Ubel F.A., Shannon D.C., Berger A.C., Cohen R.J. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 1981, 213:220-222.
2. Alberti K.G., Zimmet P., Shaw J. The metabolic syndrome--a new worldwide definition. Lancet 2005, 366:1059-1062.
3. Allan L.M., Kerr S.R., Ballard C.G., Allen J., Murray A., McLaren A.T., Kenny R.A. Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia. Dementia and Geriatric Cognitive Disorders 2005, 19:140-144.
4. Bar K.J., Berger S., Metzner M., Boettger M.K., Schulz S., Ramachandraiah C.T., Terhaar J., Voss A., Yeragani V.K., Sauer H. Autonomic dysfunction in unaffected first-degree relatives of patients suffering from schizophrenia. Schizophrenia Bulletin 2009, 36:1050-1058.
5. Bar K.J., Letzsch A., Jochum T., Wagner G., Greiner W., Sauer H. Loss of efferent vagal activity in acute schizophrenia. Journal of Psychiatric Research 2005, 39:519-527.
6. Barnes T.R. A rating scale for drug-induced akathisia. Br J Psychiatry 1989, 154:672-676.
7. Boettger S., Hoyer D., Falkenhahn K., Kaatz M., Yeragani V.K., Bar K.J. Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia. Clinical Neurophysiology 2006, 117:2715-2722.
8. Cohen H., Loewenthal U., Matar M., Kotler M. Association of autonomic dysfunction and clozapine. Heart rate variability and risk for sudden death in patients with schizophrenia on long-term psychotropic medication. British Journal of Psychiatry 2001, 179:167-171.
9. Costa M., Goldberger A.L., Peng C.K. Multiscale entropy analysis of complex physiologic time series. Physical Review Letters 2002, 89:068102.
10. Costa M., Goldberger A.L., Peng C.K. Reply: Comment on multiscale entropy analysis of complex physiologic time series. Physical Review Letters 2003, 91:119802.
11. Dixon L., Weiden P., Delahanty J., Goldberg R., Postrado L., Lucksted A., Lehman A. Prevalence and correlates of diabetes in national schizophrenia samples. Schizophrenia Bulletin 2000, 26:903-912.
12. Escudero J., Abasolo D., Hornero R., Espino P., Lopez M. Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy. Physiological Measurement 2006, 27:1091-1106.
13. Franklin S.S., Lopez V.A., Wong N.D., Mitchell G.F., Larson M.G., Vasan R.S., Levy D. Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart Study. Circulation 2009, 119:243-250.
14. Fujibayashi M., Matsumoto T., Kishida I., Kimura T., Ishii C., Ishii N., Moritani T. Autonomic nervous system activity and psychiatric severity in schizophrenia. Psychiatry and Clinical Neurosciences 2009, 63:538-545.
15. Gehi A.K., Lampert R., Veledar E., Lee F., Goldberg J., Jones L., Murrah N., Ashraf A., Vaccarino V. A twin study of metabolic syndrome and autonomic tone. Journal of Cardiovascular Electrophysiology 2009, 20:422-428.
16. Goldberger A.L., Amaral L.A., Glass L., Hausdorff J.M., Ivanov P.C., Mark R.G., Mietus J.E., Moody G.B., Peng C.K., Stanley H.E. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation 2000, 101:E215-220.
17. Goldberger, A.L., Amaral, L.A., Hausdorff, J.M., Ivanov, P., Peng, C.K., and Stanley, H.E., 2002a. Fractal dynamics in physiology: alterations with disease and aging. Proceedings of the National Academy of Sciences of the United States of America 99 Suppl 1, 2466-2472.
18. Goldberger A.L., Peng C.K., Lipsitz L.A. What is physiologic complexity and how does it change with aging and disease?. Neurobiology of Aging 2002, 23:23-26.
19. Goldberger J.J., Challapalli S., Tung R., Parker M.A., Kadish A.H. Relationship of heart rate variability to parasympathetic effect. Circulation 2001, 103:1977-1983.
20. Henry B.L., Minassian A., Paulus M.P., Geyer M.A., Perry W. Heart rate variability in bipolar mania and schizophrenia. Journal of Psychiatric Research 2010, 44:168-176.
21. Hert M.D.E., Schreurs V., Vancampfort D. Metabolic syndrome in people with schizophrenia: a review. World Psychiatry 2009, 8:15-22.
22. Ivanov P.C., Amaral L.A., Goldberger A.L., Havlin S., Rosenblum M.G., Struzik Z.R., Stanley H.E. Multifractality in human heartbeat dynamics. Nature 1999, 399:461-465.
23. Jindal R.D., Keshavan M.S., Eklund K., Stevens A., Montrose D.M., Yeragani V.K. Beat-to-beat heart rate and QT interval variability in first episode neuroleptic-naive psychosis. Schizophrenia Research 2009, 113:176-180.
24. Jones S.H., Thornicroft G., Coffey M., Dunn G. A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). British Journal of Psychiatry 1995, 166:654-659.
25. Katona P.G., Jih F. Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. Journal of Applied Physiology 1975, 39:801-805.
26. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13:261-276.
27. Kelly T.N., Gu D., Chen J., Huang J.F., Chen J.C., Duan X., Wu X., Yau C.L., Whelton P.K., He J. Hypertension subtype and risk of cardiovascular disease in Chinese adults. Circulation 2008, 118:1558-1566.
28. Kemp A.H., Quintana D.S., Gray M.A., Felmingham K.L., Brown K., Gatt J.M. Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biological Psychiatry 2010, 67:1067-1074.
29. Kim J.H., Ann J.H., Lee J. Relationship between heart rate variability and the severity of psychotic symptoms in schizophrenia. Acta Neuropsychiatrica 2011, 23:161-166.
30. Kim J.H., Yi S.H., Park K.T., Ahn Y.M., Lee K.Y., Yang S.A., Kim Y.S. Diminished neurocardiac dynamics associated with antipsychotic-induced extrapyramidal syndrome. European Neuropsychopharmacology 2006, 16:459-463.
31. Kohli P., Greenland P. Role of the metabolic syndrome in risk assessment for coronary heart disease. JAMA 2006, 295:819-821.
32. Koskinen T., Kahonen M., Jula A., Mattsson N., Laitinen T., Keltikangas-Jarvinen L., Viikari J., Valimaki I., Ronnemaa T., Raitakari O.T. Metabolic syndrome and short-term heart rate variability in young adults. The cardiovascular risk in young Finns study. Diabetic Medicine 2009, 26:354-361.
33. L'Italien G.J., Casey D.E., Kan H.J., Carson W.H., Marcus R.N. Comparison of metabolic syndrome incidence among schizophrenia patients treated with aripiprazole versus olanzapine or placebo. The Journal of Clinical Psychiatry 2007, 68:1510-1516.
34. Lakka H.M., Laaksonen D.E., Lakka T.A., Niskanen L.K., Kumpusalo E., Tuomilehto J., Salonen J.T. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002, 288:2709-2716.
35. Lamberti J.S., Olson D., Crilly J.F., Olivares T., Williams G.C., Tu X., Tang W., Wiener K., Dvorin S., Dietz M.B. Prevalence of the metabolic syndrome among patients receiving clozapine. The American Journal of Psychiatry 2006, 163:1273-1276.
36. Liao D., Sloan R.P., Cascio W.E., Folsom A.R., Liese A.D., Evans G.W., Cai J., Sharrett A.R. Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care 1998, 21:2116-2122.
37. Malliani A., Lombardi F., Pagani M. Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms. British Heart Journal 1994, 71:1-2.
38. Mietus J.E., Peng C.K., Henry I., Goldsmith R.L., Goldberger A.L. The pNNx files: re-examining a widely used heart rate variability measure. Heart 2002, 88:378-380.
39. Min K.B., Min J.Y., Paek D., Cho S.I. The impact of the components of metabolic syndrome on heart rate variability: using the NCEP-ATP III and IDF definitions. Pacing and Clinical Electrophysiology 2008, 31:584-591.
40. Mizuno T., Takahashi T., Cho R.Y., Kikuchi M., Murata T., Takahashi K., Wada Y. Assessment of EEG dynamical complexity in Alzheimer's disease using multiscale entropy. Clinical Neurophysiology 2010, 121:1438-1446.
41. Mujica-Parodi L.R., Yeragani V., Malaspina D. Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology 2005, 51:10-15.
42. Norris P.R., Anderson S.M., Jenkins J.M., Williams A.E., Morris J.A. Heart rate multiscale entropy at three hours predicts hospital mortality in 3,154 trauma patients. Shock 2008, 30:17-22.
43. Norris P.R., Stein P.K., Morris J.A. Reduced heart rate multiscale entropy predicts death in critical illness: a study of physiologic complexity in 285 trauma patients. Journal of Critical Care 2008, 23:399-405.
44. Okada T., Toichi M., Sakihama M. Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia. Journal of Clinical Psychopharmacology 2003, 23:441-447.
45. Piccirillo G., Magri D., Matera S., Magnanti M., Torrini A., Pasquazzi E., Schifano E., Velitti S., Marigliano V., Quaglione R., Barilla F. QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study. European Heart Journal 2007, 28:1344-1350.
46. Pincus, S.M., 1991. Approximate entropy as a measure of system complexity. Proceedings of the National Academy of Sciences of the United States of America 88, 2297-2301.
47. Pizzuti G.P., Cifaldi S., Nolfe G. Digital sampling rate and ECG analysis. Journal of Biomedical Engineering 1985, 7:247-250.
48. Pomeranz B., Macaulay R.J., Caudill M.A., Kutz I., Adam D., Gordon D., Kilborn K.M., Barger A.C., Shannon D.C., Cohen R.J., et al. Assessment of autonomic function in humans by heart rate spectral analysis. American Journal of Physiology 1985, 248:H151-153.
49. Porges S.W. A phylogenetic journey through the vague and ambiguous Xth cranial nerve: a commentary on contemporary heart rate variability research. Biological Psychology 2007, 74:301-307.
50. Protzner A.B., Valiante T.A., Kovacevic N., McCormick C., McAndrews M.P. Hippocampal signal complexity in mesial temporal lobe epilepsy: a noisy brain is a healthy brain. Archives Italiennes de Biologie 2011, 148:289-297.
51. Rechlin T., Claus D., Weis M. Heart rate variability in schizophrenic patients and changes of autonomic heart rate parameters during treatment with clozapine. Biological Psychiatry 1994, 35:888-892.
52. Richman J.S., Moorman J.R. Physiological time-series analysis using approximate entropy and sample entropy. American Journal of Physiology 2000, 278:H2039-2049.
53. Ryan M.C., Collins P., Thakore J.H. Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. The American Journal of Psychiatry 2003, 160:284-289.
54. Sarafidis P.A., Nilsson P.M. The metabolic syndrome: a glance at its history. Journal of Hypertension 2006, 24:621-626.
55. Takahashi T., Cho R.Y., Mizuno T., Kikuchi M., Murata T., Takahashi K., Wada Y. Antipsychotics reverse abnormal EEG complexity in drug-naive schizophrenia: a multiscale entropy analysis. NeuroImage 2010, 51:173-182.
56. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996, 93:1043-1065. Task-Force.
57. Taylor J.A., Carr D.L., Myers C.W., Eckberg D.L. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation 1998, 98:547-555.
58. Toichi M., Kubota Y., Murai T., Kamio Y., Sakihama M., Toriuchi T., Inakuma T., Sengoku A., Miyoshi K. The influence of psychotic states on the autonomic nervous system in schizophrenia. International Journal of Psychophysiology 1999, 31:147-154.
59. Tsivgoulis G., Alexandrov A.V., Wadley V.G., Unverzagt F.W., Go R.C., Moy C.S., Kissela B., Howard G. Association of higher diastolic blood pressure levels with cognitive impairment. Neurology 2009, 73:589-595.
60. Vikman S., Makikallio T.H., Yli-Mayry S., Pikkujamsa S., Koivisto A.M., Reinikainen P., Airaksinen K.E., Huikuri H.V. Altered complexity and correlation properties of R-R interval dynamics before the spontaneous onset of paroxysmal atrial fibrillation. Circulation 1999, 100:2079-2084.
61. Yang A.C., Chen T.J., Tsai S.J., Hong C.J., Kuo C.H., Yang C.H., Kao K.P. BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects. American Journal of Medical Genetics B 2010, 153:1024-1030.
62. Yang A.C., Tsai S.J., Hong C.J., Yang C.H., Hsieh C.H., Liu M.E. Association between heart rate variability and cognitive function in elderly community-dwelling men without dementia: a preliminary report. Journal of the American Geriatrics Society 2008, 56:958-960.
63. Yang A.C., Tsai S.J., Yang C.H., Kuo C.H., Chen T.J., Hong C.J. Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. Journal of Affective Disorders 2011, 131:179-185.