Beat-to-beat heart rate and QT interval variability in first episode neuroleptic-naive psychosis

Schizophrenia Research

Volumn 113, Issue 2-3, 2009, Pages 176-180

  Jindal, Ripu D ^a,b   Keshavan, Matcheri S ^a,c   Eklund, Kevin ^a   Stevens, Angela ^b   Montrose, Debra M ^a   Yeragani, Vikram K ^d,e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c HARVARD MEDICAL SCHOOL   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Autonomic dysfunction; Psychosis; QT variability; RR variability; Schizophrenia; Sudden death

Indexed keywords

ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSIVE PSYCHOSIS; FEMALE; HEART ARRHYTHMIA; HEART RATE VARIABILITY; HEART REPOLARIZATION; HUMAN; MALE; PARANOID SCHIZOPHRENIA; PRIORITY JOURNAL; QT INTERVAL; RR INTERVAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; SUDDEN DEATH;

ADOLESCENT; ADULT; ARRHYTHMIAS, CARDIAC; BRIEF PSYCHIATRIC RATING SCALE; ELECTROCARDIOGRAPHY; FEMALE; FOURIER ANALYSIS; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; PSYCHOTIC DISORDERS; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 68049142110     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2009.06.003     Document Type: Article

References (51)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington DC
2. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93 (1996) 1043-1065
3. Agelink M.W., Majewski T., Wurthmann C., Lukas K., Ullrich H., Linka T., and Klieser E. Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine. J. Clin. Psychopharmacol. 21 (2001) 8-13
4. Atiga W.L., Calkins H., Lawrence J.H., Tomaselli G.F., Smith J.M., and Berger R.D. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J. Cardiovasc. Electrophysiol. 9 (1998) 899-908
5. Bar K.J., Koschke M., Boettger M.K., Berger S., Kabisch A., Sauer H., et al. Acute psychosis leads to increased QT variability in patients suffering from schizophrenia. Schizophr. Res. 95 (2007) 115-123
6. Bar K.J., Boettger M.K., Schulz S., Harzendorf C., Agelink M.W., Yeragani V.K., et al. The interaction between pupil function and cardiovascular regulation in patients with acute schizophrenia. Clin. Neurophysiol. 119 (2008) 2209-2213
7. Bar K.J., Wernich K., Boettger S., Cordes J., Boettger M.K., Loffler S., et al. Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia. Psychiatry Res. 157 (2008) 255-257
8. Barbas H., Saha S., Rempel-Clower N., and Ghashghaei T. Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression. BMC Neurosci. 4 (2003) 25
9. Berger R.D., Kasper E.K., Baughman K.L., Marban E., Calkins H., and Tomaselli G.F. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 96 (1997) 1557-1565
10. Bikkina M., Alpert M.A., Mukerji R., Mulekar M., Cheng B.Y., and Mukerji V. Diminished short-term heart rate variability predicts inducible ventricular tachycardia. Chest 113 (1998) 312-316
11. Boettger S., Hoyer D., Falkenhahn K., Kaatz M., Yeragani V.K., and Bar K.J. Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia. Clin. Neurophysiol. 117 (2006) 2715-2722
12. Bonnemeier H., Hartmann F., Wiegand U.K., Bode F., Katus H.A., and Richardt G. Course and prognostic implications of QT interval and QT interval variability after primary coronary angioplasty in acute myocardial infarction. J. Am. Coll. Cardiol. 37 (2001) 44-50
13. Bonnet M.H., and Arand D.L. Heart rate variability in insomniacs and matched normal sleepers. Psychosom. Med. 60 (1998) 610-615
14. Brown S., Inskip H., and Barraclough B. Causes of the excess mortality of schizophrenia. Br. J. Psychiatry 177 (2000) 212-217
15. Dawson M.E., Nuechterlein K.H., Schell A.M., Gitlin M., and Ventura J. Autonomic abnormalities in schizophrenia. State or trait indicators?. Arch. Gen. Psychiatry 51 (1994) 813-824
16. Dekker J.M., Schouten E.G., Klootwijk P., Pool J., Swenne C.A., and Kromhout D. Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am. J. Epidemiol. 145 (1997) 899-908
17. Eschweiler G.W., Bartels M., Langle G., Wild B., Gaertner I., and Nickola M. Heart-rate variability (HRV) in the ECG trace of routine EEGs: fast monitoring for the anticholinergic effects of clozapine and olanzapine?. Pharmacopsychiatry 35 (2002) 96-100
18. First M. Structured Clinical Interview DSM-IV axis I disorders-Patient edition (SCID-I/P) (1995), New York State Psychiatric Institute, New York
19. Guy W. ECDEU Assessment Manual for Psychopharmacology. Revised Edition (1976), US Department of Health, Education and Welfare, Washington, DC
20. Hazlett H., Dawson M.E., Schell A.M., and Nuechterlein K.H. Electrodermal activity as a prodromal sign in schizophrenia. Biol. Psychiatry. 41 (1997) 111-113
21. Huikuri H.V., Makikallio T.H., Airaksinen K.E., Seppanen T., Puukka P., Raiha I.J., and Sourander L.B. Power-law relationship of heart rate variability as a predictor of mortality in the elderly. Circulation 97 (1998) 2031-2036
22. Hultman C.M., Ohlund L.S., Wieselgren I.M., Ohman A., and Ost L.G. Electrodermal activity and social network as predictors of outcome of episodes in schizophrenia. J. Abnorm. Psychol. 105 (1996) 626-636
23. Kay S.R., Fiszbein A., and Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13 (1987) 261-276
24. Kleiger R.E., Miller J.P., Bigger Jr. J.T., and Moss A.J. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am. J. Cardiol. 59 (1987) 256-262
25. Lopes-Machado E.Z., Crippa J.A., Hallak J.E., Guimaraes F.S., and Zuardi A.W. Electrodermically nonresponsive schizophrenia patients make more errors in the Stroop Color Word Test, indicating selective attention deficit. Schizophr. Bull. 28 (2002) 459-466
26. Maison-Blanche P., and Coumel P. Changes in repolarization dynamicity and the assessment of the arrhythmic risk. Pacing Clin. Electrophysiol. 20 (1997) 2614-2624
27. Molgaard H., Sorensen K.E., and Bjerregaard P. Attenuated 24-h heart rate variability in apparently healthy subjects, subsequently suffering sudden cardiac death. Clin. Auton. Res. 1 (1991) 233-237
28. Morris S.K., Granholm E., Sarkin A.J., and Jeste D.V. Effects of schizophrenia and aging on pupillographic measures of working memory. Schizophr. Res. 27 (1997) 119-128
29. Mortensen P.B., and Juel K. Mortality and causes of death in schizophrenic patients in Denmark. Acta Psychiatr. Scand. 81 (1990) 372-377
30. Mujica-Parodi L.R., Yeragani V., and Malaspina D. Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology 51 (2005) 10-15
31. Odemuyiwa O., Malik M., Farrell T., Bashir Y., Poloniecki J., and Camm J. Comparison of the predictive characteristics of heart rate variability index and left ventricular ejection fraction for all-cause mortality, arrhythmic events and sudden death after acute myocardial infarction. Am. J. Cardiol. 68 (1991) 434-439
32. Okada T., Toichi M., and Sakihama M. Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia. J. Clin. Psychopharmacol. 23 (2003) 441-447
33. Ongur D., and Price J.L. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb. Cortex 10 (2000) 206-219
34. Overall J.E., and Gorham D.R. The Brief Psychiatric Rating Scale. Psychol. Rep. 10 (1962) 779-812
35. Perry W., Felger T., and Braff D. The relationship between skin conductance hyporesponsivity and perseverations in schizophrenia patients. Biol. Psychiatry 44 (1998) 459-465
36. Phillips M.L., Drevets W.C., Rauch S.L., and Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol. Psychiatry 54 (2003) 515-528
37. Pohl R., Balon R., Jayaraman A., Doll R.G., and Yeragani V. Effect of fluoxetine, pemoline and placebo on heart period and QT variability in normal humans. J. Psychosom. Res. 55 (2003) 247-251
38. Priori S.G., Aliot E., Blomstrom-Lundqvist C., Bossaert L., Breithardt G., and Brugada P. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur. Heart J. 22 (2001) 1374-1450
39. Ray W.A., Chung C.P., Murray K.T., Hall K., and Stein C.M. Atypical antipsychotic drugs and the risk of sudden cardiac death. N. Engl. J. Med. 360 (2009) 225-235
40. Ruschena D., Mullen P.E., Burgess P., Cordner S.M., Barry-Walsh J., Drummer O.H., et al. Sudden death in psychiatric patients. Br. J. Psychiatry 172 (1998) 331-336
41. Schell A.M., Dawson M.E., Rissling A., Ventura J., Subotnik K.L., Gitlin M.J., and Nuechterlein K.H. Electrodermal predictors of functional outcome and negative symptoms in schizophrenia. Psychophysiology 42 (2005) 483-492
42. Schiffer R.A., Sigal M., and Mintz M. Delayed habituation of the skin-conductance orienting response correlates with impaired performance on the Wisconsin Card Sorting Task in schizophrenia. Psychiatry Res. 65 (1996) 107-112
43. Shenton M.E., Dickey C.C., Frumin M., and McCarley R.W. A review of MRI findings in schizophrenia. Schizophr. Res. 49 (2001) 1-52
44. Straus S.M., Bleumink G.S., Dieleman J.P., van der Lei J., t Jong G.W., Kingma J.H., et al. Antipsychotics and the risk of sudden cardiac death. Arch. Intern. Med. 164 (2004) 1293-1297
45. Toichi M., Kubota Y., Murai T., Kamio Y., Sakihama M., Toriuchi T., et al. The influence of psychotic states on the autonomic nervous system in schizophrenia. Int. J. Psychophysiol. 31 (1999) 147-154
46. Valkonen-Korhonen M., Tarvainen M.P., Ranta-Aho P., Karjalainen P.A., Partanen J., Karhu J., and Lehtonen J. Heart rate variability in acute psychosis. Psychophysiology 40 (2003) 716-726
47. Vrtovec B., Starc V., and Starc R. Beat-to-beat QT interval variability in coronary patients. J. Electrocardiol. 33 (2000) 119-125
48. Yeragani V.K., Pohl R., Balon R., Jampala V.C., and Jayaraman A. Twenty-four-hour QT interval variability: increased QT variability during sleep in patients with panic disorder. Neuropsychobiology 46 (2002) 1-6
49. Yeragani V.K., Pohl R., Jampala V.C., Balon R., Kay J., and Igel G. Effect of posture and isoproterenol on beat-to-beat heart rate and QT variability. Neuropsychobiology 41 (2000) 113-123
50. Yeragani V.K., Pohl R., Jampala V.C., Balon R., Ramesh C., and Srinivasan K. Effects of nortriptyline and paroxetine on QT variability in patients with panic disorder. Depress. Anxiety 11 (2000) 126-130
51. Yeragani V.K., Pohl R., Jampala V.C., Balon R., Ramesh C., and Srinivasan K. Increased QT variability in patients with panic disorder and depression. Psychiatry Res. 93 (2000) 225-235