메뉴 건너뛰기




Volumn 18, Issue 6, 2013, Pages 645-651

Vascularized composite allotransplantation: Towards tolerance and the importance of skin-specific immunobiology

Author keywords

Immunosuppression; Skin immunobiology; Tolerance; Transplant; Vascularized composite allotransplantation

Indexed keywords

RAPAMYCIN; TACROLIMUS;

EID: 84888293513     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000022     Document Type: Review
Times cited : (19)

References (51)
  • 1
    • 78650806321 scopus 로고    scopus 로고
    • The international registry on hand and composite tissue transplantation
    • Petruzzo P, Lanzetta M, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2010; 90:1590-1594.
    • (2010) Transplantation , vol.90 , pp. 1590-1594
    • Petruzzo, P.1    Lanzetta, M.2    Dubernard, J.M.3
  • 2
    • 84876087639 scopus 로고    scopus 로고
    • Standardizing skin biopsy sampling to assess rejection in vascularized composite allotransplantation
    • Hautz T, Zelger BG, Weissenbacher A, et al. Standardizing skin biopsy sampling to assess rejection in vascularized composite allotransplantation. Clin Transplant 2013; 27:E81-E90.
    • (2013) Clin Transplant , vol.27
    • Hautz, T.1    Zelger, B.G.2    Weissenbacher, A.3
  • 3
    • 0015057180 scopus 로고
    • Organ transplantation (skin, kidney, heart) and the plastic surgeon
    • Murray JE. Organ transplantation (skin, kidney, heart) and the plastic surgeon. Plast Reconstr Surg 1971; 47:425-431.
    • (1971) Plast Reconstr Surg , vol.47 , pp. 425-431
    • Murray, J.E.1
  • 4
    • 0000682701 scopus 로고
    • The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the war wounds committee of the medical research council
    • Medawar PB. The behaviour and fate of skin autografts and skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. J Anat 1944; 78:176-199.
    • (1944) J Anat , vol.78 , pp. 176-199
    • Medawar, P.B.1
  • 5
    • 0016351186 scopus 로고
    • Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen
    • Steinmuller D, Lofgreen JS. Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen. Nature 1974; 248:796-797.
    • (1974) Nature , vol.248 , pp. 796-797
    • Steinmuller, D.1    Lofgreen, J.S.2
  • 6
    • 0019064688 scopus 로고
    • Evidence of skin-specific alloantigens in cell-mediated cytotoxicity reactions
    • Steinmuller D, Tyler JD. Evidence of skin-specific alloantigens in cell-mediated cytotoxicity reactions. Transplant Proc 1980; 12:107-113.
    • (1980) Transplant Proc , vol.12 , pp. 107-113
    • Steinmuller, D.1    Tyler, J.D.2
  • 7
    • 0003029748 scopus 로고    scopus 로고
    • The enigma of skin allograft rejection
    • Steinmuller D. The enigma of skin allograft rejection. Transplant Rev 1998; 12:42-57.
    • (1998) Transplant Rev , vol.12 , pp. 42-57
    • Steinmuller, D.1
  • 8
    • 0023266489 scopus 로고
    • The skin immune system (SIS): Distribution and immunophenotype of lymphocyte subpopulations in normal human skin
    • Bos JD, Zonneveld I, Das PK, et al. The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 1987; 88:569-573.
    • (1987) J Invest Dermatol , vol.88 , pp. 569-573
    • Bos, J.D.1    Zonneveld, I.2    Das, P.K.3
  • 9
    • 33646046528 scopus 로고    scopus 로고
    • The vast majority of CLA+ T cells are resident in normal skin
    • Clark RA, Chong B, Mirchandani N, et al. The vast majority of CLA+ T cells are resident in normal skin. J Immunol 2006; 176:4431-4439.
    • (2006) J Immunol , vol.176 , pp. 4431-4439
    • Clark, R.A.1    Chong, B.2    Mirchandani, N.3
  • 10
    • 84861462335 scopus 로고    scopus 로고
    • Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells
    • Seneschal J, Clark RA, Gehad A, et al. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 2012; 36:873-884.
    • (2012) Immunity , vol.36 , pp. 873-884
    • Seneschal, J.1    Clark, R.A.2    Gehad, A.3
  • 11
    • 84856241320 scopus 로고    scopus 로고
    • The impact of current immunosuppression strategies in renal transplantation on the field of reconstructive transplantation
    • Chang J, Davis CL, Mathes DW. The impact of current immunosuppression strategies in renal transplantation on the field of reconstructive transplantation. J Reconstr Microsurg 2012; 28:7-19.
    • (2012) J Reconstr Microsurg , vol.28 , pp. 7-19
    • Chang, J.1    Davis, C.L.2    Mathes, D.W.3
  • 12
    • 79960138137 scopus 로고    scopus 로고
    • Achievements and challenges in composite tissue allotransplantation
    • Schneeberger S, Landin L, Jableki J, et al. Achievements and challenges in composite tissue allotransplantation. Transpl Int 2011; 24:760-769.
    • (2011) Transpl Int , vol.24 , pp. 760-769
    • Schneeberger, S.1    Landin, L.2    Jableki, J.3
  • 13
    • 84879147505 scopus 로고    scopus 로고
    • National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. U.S. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
    • National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. U.S. Renal Data System, USRDS 2012 Annual Data Report: atlas of chronic kidney disease and end-stage renal disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
    • (2012) Renal Data System, USRDS 2012 Annual Data Report: Atlas of Chronic Kidney Disease and End-stage Renal Disease in the United States
  • 14
    • 33644676984 scopus 로고    scopus 로고
    • Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: Comparison with basiliximab induction: Long-term results
    • Kaufman DB, Leventhal JR, Axelrod D, et al. Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: comparison with basiliximab induction: long-term results. Am J Transplant 2005; 5:2539-2548.
    • (2005) Am J Transplant , vol.5 , pp. 2539-2548
    • Kaufman, D.B.1    Leventhal, J.R.2    Axelrod, D.3
  • 15
    • 75149140435 scopus 로고    scopus 로고
    • Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation
    • Unadkat JV, Schneeberger S, Horibe EH, et al. Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation. Am J Transplant 2010; 10:251-261.
    • (2010) Am J Transplant , vol.10 , pp. 251-261
    • Unadkat, J.V.1    Schneeberger, S.2    Horibe, E.H.3
  • 17
    • 80052874431 scopus 로고    scopus 로고
    • Immuno-intervention for the induction of transplantation tolerance through mixed chimerism
    • Sachs DH, Sykes M, Kawai T, et al. Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol 2011; 23:165-173.
    • (2011) Semin Immunol , vol.23 , pp. 165-173
    • Sachs, D.H.1    Sykes, M.2    Kawai, T.3
  • 18
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-361.
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 19
    • 84863229939 scopus 로고    scopus 로고
    • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation
    • Leventhal J, Abecassis M, Miller J, et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012; 4: 124ra28.
    • (2012) Sci Transl Med , vol.4
    • Leventhal, J.1    Abecassis, M.2    Miller, J.3
  • 20
    • 0028860210 scopus 로고
    • Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys
    • Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59:256-262.
    • (1995) Transplantation , vol.59 , pp. 256-262
    • Kawai, T.1    Cosimi, A.B.2    Colvin, R.B.3
  • 21
    • 0033931659 scopus 로고    scopus 로고
    • Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine
    • Schwarze ML, Menard MT, Fuchimoto Y, et al. Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine. Ann Thorac Surg 2000; 70:131-138.
    • (2000) Ann Thorac Surg , vol.70 , pp. 131-138
    • Schwarze, M.L.1    Menard, M.T.2    Fuchimoto, Y.3
  • 22
    • 33751188263 scopus 로고    scopus 로고
    • Predictors of organ allograft tolerance following hematopoietic cell transplantation
    • Horner BM, Cina RA, Wikiel KJ, et al. Predictors of organ allograft tolerance following hematopoietic cell transplantation. Am J Transplant 2006; 6:2894-2902.
    • (2006) Am J Transplant , vol.6 , pp. 2894-2902
    • Horner, B.M.1    Cina, R.A.2    Wikiel, K.J.3
  • 23
    • 84873411393 scopus 로고    scopus 로고
    • Induction of tolerance of vascularized composite allografts
    • Leonard DA, Cetrulo CL Jr, McGrouther DA, et al. Induction of tolerance of vascularized composite allografts. Transplantation 2013; 95:403-409.
    • (2013) Transplantation , vol.95 , pp. 403-409
    • Leonard, D.A.1    Cetrulo Jr., C.L.2    McGrouther, D.A.3
  • 24
    • 84858403778 scopus 로고    scopus 로고
    • Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras
    • Mathes DW, Hwang B, Graves SS, et al. Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras. Transplantation 2011; 92:1301-1308.
    • (2011) Transplantation , vol.92 , pp. 1301-1308
    • Mathes, D.W.1    Hwang, B.2    Graves, S.S.3
  • 25
    • 1442360359 scopus 로고    scopus 로고
    • Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine
    • Hettiaratchy S, Melendy E, Randolph MA, et al. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation 2004; 77:514-521.
    • (2004) Transplantation , vol.77 , pp. 514-521
    • Hettiaratchy, S.1    Melendy, E.2    Randolph, M.A.3
  • 26
    • 67649586583 scopus 로고    scopus 로고
    • Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model
    • Kuo YR, Goto S, Shih HS, et al. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009; 87:1769-1777.
    • (2009) Transplantation , vol.87 , pp. 1769-1777
    • Kuo, Y.R.1    Goto, S.2    Shih, H.S.3
  • 27
    • 85172641046 scopus 로고    scopus 로고
    • Vascularized composite allograft tolerance across MHCbarriers in a large animal model
    • in press
    • Leonard DA, Kurtz JM, Mallard C, et al. Vascularized composite allograft tolerance across MHCbarriers in a large animal model. Am J Transplant 2013; in press.
    • (2013) Am J Transplant
    • Leonard, D.A.1    Kurtz, J.M.2    Mallard, C.3
  • 28
    • 81455132393 scopus 로고    scopus 로고
    • Biologics and donor bone marrow cells for targeted immunomodulation in vascularized composite allotransplantation: A translational trial in swine
    • Wachtman GS, Wimmers EG, Gorantla VS, et al. Biologics and donor bone marrow cells for targeted immunomodulation in vascularized composite allotransplantation: a translational trial in swine. Transplant Proc 2011; 43:3541-3544.
    • (2011) Transplant Proc , vol.43 , pp. 3541-3544
    • Wachtman, G.S.1    Wimmers, E.G.2    Gorantla, V.S.3
  • 30
    • 84872290207 scopus 로고    scopus 로고
    • Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression
    • Schneeberger S, Gorantla VS, Brandacher G, et al. Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. Ann Surg 2013; 257:345-351.
    • (2013) Ann Surg , vol.257 , pp. 345-351
    • Schneeberger, S.1    Gorantla, V.S.2    Brandacher, G.3
  • 31
    • 0018176271 scopus 로고
    • Immunologic functions of Ia-bearing epidermal Langerhans cells
    • Stingl G, Katz SI, Clement L, et al. Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 1978; 121:2005-2013.
    • (1978) J Immunol , vol.121 , pp. 2005-2013
    • Stingl, G.1    Katz, S.I.2    Clement, L.3
  • 32
    • 0019777599 scopus 로고
    • Induction of lymphocyte differentiation by epidermal cultures
    • Rubenfeld MR, Silverstone AE, Knowles DM, et al. Induction of lymphocyte differentiation by epidermal cultures. J Invest Dermatol 1981; 77:221-224.
    • (1981) J Invest Dermatol , vol.77 , pp. 221-224
    • Rubenfeld, M.R.1    Silverstone, A.E.2    Knowles, D.M.3
  • 33
    • 84856072398 scopus 로고    scopus 로고
    • Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients
    • Clark RA, Watanabe R, Teague JE, et al. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med 2012; 4:117ra7.
    • (2012) Sci Transl Med , vol.4
    • Clark, R.A.1    Watanabe, R.2    Teague, J.E.3
  • 34
    • 84862777442 scopus 로고    scopus 로고
    • Skin infection generates nonmigratory memory CD8+ T(RM) cells providing global skin immunity
    • Jiang X, Clark RA, Liu L, et al. Skin infection generates nonmigratory memory CD8+ T(RM) cells providing global skin immunity. Nature 2012; 483:227-231.
    • (2012) Nature , vol.483 , pp. 227-231
    • Jiang, X.1    Clark, R.A.2    Liu, L.3
  • 35
    • 33846005781 scopus 로고    scopus 로고
    • IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    • Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 2007; 109:194-202.
    • (2007) Blood , vol.109 , pp. 194-202
    • Clark, R.A.1    Kupper, T.S.2
  • 36
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • Clark RA, Huang SJ, Murphy GF, et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 2008; 205:2221-2234.
    • (2008) J Exp Med , vol.205 , pp. 2221-2234
    • Clark, R.A.1    Huang, S.J.2    Murphy, G.F.3
  • 37
    • 33845941704 scopus 로고    scopus 로고
    • Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation
    • Eljaafari A, Badet L, Kanitakis J, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006; 82:1764-1768.
    • (2006) Transplantation , vol.82 , pp. 1764-1768
    • Eljaafari, A.1    Badet, L.2    Kanitakis, J.3
  • 38
    • 55849107041 scopus 로고    scopus 로고
    • The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo
    • Vukmanovic-Stejic M, Agius E, Booth N, et al. The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest 2008; 118:3639-3650.
    • (2008) J Clin Invest , vol.118 , pp. 3639-3650
    • Vukmanovic-Stejic, M.1    Agius, E.2    Booth, N.3
  • 39
    • 46949111560 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells maintain immune homeostasis in the skin
    • Dudda JC, Perdue N, Bachtanian E, et al. Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med 2008; 205:1559-1565.
    • (2008) J Exp Med , vol.205 , pp. 1559-1565
    • Dudda, J.C.1    Perdue, N.2    Bachtanian, E.3
  • 40
    • 33645067654 scopus 로고    scopus 로고
    • Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
    • Tadokoro CE, Shakhar G, Shen S, et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med 2006; 203:505-511.
    • (2006) J Exp Med , vol.203 , pp. 505-511
    • Tadokoro, C.E.1    Shakhar, G.2    Shen, S.3
  • 41
    • 80054737381 scopus 로고    scopus 로고
    • Skin as a peripheral lymphoid organ: Revisiting the concept of skin-associated lymphoid tissues
    • Egawa G, Kabashima K. Skin as a peripheral lymphoid organ: revisiting the concept of skin-associated lymphoid tissues. J Invest Dermatol 2011; 131:2178-2185.
    • (2011) J Invest Dermatol , vol.131 , pp. 2178-2185
    • Egawa, G.1    Kabashima, K.2
  • 42
    • 79251577059 scopus 로고    scopus 로고
    • Glucocorticosteroids modify Langerhans cells to produce TGF-beta and expand regulatory T cells
    • Stary G, Klein I, Bauer W, et al. Glucocorticosteroids modify Langerhans cells to produce TGF-beta and expand regulatory T cells. J Immunol 2011; 186:103-112.
    • (2011) J Immunol , vol.186 , pp. 103-112
    • Stary, G.1    Klein, I.2    Bauer, W.3
  • 43
    • 56749152272 scopus 로고    scopus 로고
    • Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    • Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 2008; 8:935-947.
    • (2008) Nat Rev Immunol , vol.8 , pp. 935-947
    • Merad, M.1    Ginhoux, F.2    Collin, M.3
  • 44
    • 28844492624 scopus 로고    scopus 로고
    • Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    • Kaplan DH, Jenison MC, Saeland S, et al. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005; 23:611-620.
    • (2005) Immunity , vol.23 , pp. 611-620
    • Kaplan, D.H.1    Jenison, M.C.2    Saeland, S.3
  • 45
    • 84876692378 scopus 로고    scopus 로고
    • Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells
    • van der Aar AM, Picavet DI, Muller FJ, et al. Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol 2013; 133:1240-1249.
    • (2013) J Invest Dermatol , vol.133 , pp. 1240-1249
    • Van Der-Aar, A.M.1    Picavet, D.I.2    Muller, F.J.3
  • 46
  • 47
    • 60549093645 scopus 로고    scopus 로고
    • Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses
    • Mathers AR, Janelsins BM, Rubin JP, et al. Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses. J Immunol 2009; 182:921-933.
    • (2009) J Immunol , vol.182 , pp. 921-933
    • Mathers, A.R.1    Janelsins, B.M.2    Rubin, J.P.3
  • 48
    • 76049091500 scopus 로고    scopus 로고
    • Human langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production
    • Fujita H, Nograles KE, Kikuchi T, et al. Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production. Proc Natl Acad Sci U S A 2009; 106:21795-21800.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21795-21800
    • Fujita, H.1    Nograles, K.E.2    Kikuchi, T.3
  • 49
    • 51349093240 scopus 로고    scopus 로고
    • Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    • Klechevsky E, Morita R, Liu M, et al. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 2008; 29:497-510.
    • (2008) Immunity , vol.29 , pp. 497-510
    • Klechevsky, E.1    Morita, R.2    Liu, M.3
  • 50
    • 80053307061 scopus 로고    scopus 로고
    • Revisiting traditional risk factors for rejection and graft loss after kidney transplantation
    • Dunn TB, Noreen H, Gillingham K, et al. Revisiting traditional risk factors for rejection and graft loss after kidney transplantation. Am J Transplant 2011; 11:2132-2143.
    • (2011) Am J Transplant , vol.11 , pp. 2132-2143
    • Dunn, T.B.1    Noreen, H.2    Gillingham, K.3
  • 51
    • 37249018015 scopus 로고    scopus 로고
    • Outcomes 18 months after the first human partial face transplantation
    • Dubernard JM, Lengele B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med 2007; 357:2451-2460.
    • (2007) N Engl J Med , vol.357 , pp. 2451-2460
    • Dubernard, J.M.1    Lengele, B.2    Morelon, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.