메뉴 건너뛰기




Volumn 183, Issue 6, 2013, Pages 1945-1959

Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR DEF 6; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C ZETA; RAC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84888231364     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.08.026     Document Type: Article
Times cited : (11)

References (48)
  • 1
    • 55949109631 scopus 로고    scopus 로고
    • Structural basis of protein kinase C isoform function
    • S.F. Steinberg Structural basis of protein kinase C isoform function Physiol Rev 88 2008 1341 1378
    • (2008) Physiol Rev , vol.88 , pp. 1341-1378
    • Steinberg, S.F.1
  • 2
    • 0027431089 scopus 로고
    • Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells
    • L.A. Selbie, C. Schmitz-Peiffer, Y. Sheng, and T.J. Biden Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells J Biol Chem 268 1993 24296 24302
    • (1993) J Biol Chem , vol.268 , pp. 24296-24302
    • Selbie, L.A.1    Schmitz-Peiffer, C.2    Sheng, Y.3    Biden, T.J.4
  • 3
    • 4344652068 scopus 로고    scopus 로고
    • Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms
    • R.S. Soloff, C. Katayama, M.Y. Lin, J.R. Feramisco, and S.M. Hedrick Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms J Immunol 173 2004 3250 3260
    • (2004) J Immunol , vol.173 , pp. 3250-3260
    • Soloff, R.S.1    Katayama, C.2    Lin, M.Y.3    Feramisco, J.R.4    Hedrick, S.M.5
  • 4
  • 8
    • 0021123783 scopus 로고
    • Filamentous actin bundles in the kidney
    • P.M. Andrews, and S.B. Bates Filamentous actin bundles in the kidney Anat Rec 210 1984 1 9
    • (1984) Anat Rec , vol.210 , pp. 1-9
    • Andrews, P.M.1    Bates, S.B.2
  • 9
    • 0021136835 scopus 로고
    • Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat
    • D. Vasmant, M. Maurice, and G. Feldmann Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat Anat Rec 210 1984 17 24
    • (1984) Anat Rec , vol.210 , pp. 17-24
    • Vasmant, D.1    Maurice, M.2    Feldmann, G.3
  • 10
    • 0345282940 scopus 로고    scopus 로고
    • Actin filament organization of foot processes in rat podocytes
    • K. Ichimura, H. Kurihara, and T. Sakai Actin filament organization of foot processes in rat podocytes J Histochem Cytochem 51 2003 1589 1600
    • (2003) J Histochem Cytochem , vol.51 , pp. 1589-1600
    • Ichimura, K.1    Kurihara, H.2    Sakai, T.3
  • 11
    • 0028187915 scopus 로고
    • The contractile apparatus of podocytes is arranged to counteract GBM expansion
    • W. Kriz, P. Mundel, and M. Elger The contractile apparatus of podocytes is arranged to counteract GBM expansion Contrib Nephrol 107 1994 1 9
    • (1994) Contrib Nephrol , vol.107 , pp. 1-9
    • Kriz, W.1    Mundel, P.2    Elger, M.3
  • 12
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • H. Pavenstädt, W. Kriz, and M. Kretzler Cell biology of the glomerular podocyte Physiol Rev 83 2003 253 307
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstädt, H.1    Kriz, W.2    Kretzler, M.3
  • 13
    • 0024209817 scopus 로고
    • Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man
    • D. Drenckhahn, and R.P. Franke Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man Lab Invest 59 1988 673 682
    • (1988) Lab Invest , vol.59 , pp. 673-682
    • Drenckhahn, D.1    Franke, R.P.2
  • 14
    • 0035210580 scopus 로고    scopus 로고
    • Caught flat-footed: Podocyte damage and the molecular bases of focal glomerulosclerosis
    • D. Kerjaschki Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis J Clin Invest 108 2001 1583 1587
    • (2001) J Clin Invest , vol.108 , pp. 1583-1587
    • Kerjaschki, D.1
  • 15
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • A. Hall Rho GTPases and the actin cytoskeleton Science 279 1998 509 514
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 19
    • 80052333245 scopus 로고    scopus 로고
    • Activation of RhoA in podocytes induces focal segmental glomerulosclerosis
    • L. Zhu, R. Jiang, L. Aoudjit, N. Jones, and T. Takano Activation of RhoA in podocytes induces focal segmental glomerulosclerosis J Am Soc Nephrol 22 2011 1621 1630
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1621-1630
    • Zhu, L.1    Jiang, R.2    Aoudjit, L.3    Jones, N.4    Takano, T.5
  • 20
    • 0242353260 scopus 로고    scopus 로고
    • T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse
    • S. Gupta, J.C. Fanzo, C. Hu, D. Cox, S.Y. Jang, A.E. Lee, S. Greenberg, and A.B. Pernis T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse J Biol Chem 278 2003 43541 43549
    • (2003) J Biol Chem , vol.278 , pp. 43541-43549
    • Gupta, S.1    Fanzo, J.C.2    Hu, C.3    Cox, D.4    Jang, S.Y.5    Lee, A.E.6    Greenberg, S.7    Pernis, A.B.8
  • 21
    • 0037382339 scopus 로고    scopus 로고
    • Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
    • S. Gupta, A. Lee, C. Hu, J. Fanzo, I. Goldberg, G. Cattoretti, and A.B. Pernis Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system Hum Immunol 64 2003 389 401
    • (2003) Hum Immunol , vol.64 , pp. 389-401
    • Gupta, S.1    Lee, A.2    Hu, C.3    Fanzo, J.4    Goldberg, I.5    Cattoretti, G.6    Pernis, A.B.7
  • 22
    • 1542269066 scopus 로고    scopus 로고
    • DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA
    • K.J. Mavrakis, K.J. McKinlay, P. Jones, and F. Sablitzky DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA Exp Cell Res 294 2004 335 344
    • (2004) Exp Cell Res , vol.294 , pp. 335-344
    • Mavrakis, K.J.1    McKinlay, K.J.2    Jones, P.3    Sablitzky, F.4
  • 23
    • 34447530933 scopus 로고    scopus 로고
    • Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation
    • T. Samson, C. Will, A. Knoblauch, L. Sharek, K. von der Mark, K. Burridge, and V. Wixler Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation J Biol Chem 282 2007 15730 15742
    • (2007) J Biol Chem , vol.282 , pp. 15730-15742
    • Samson, T.1    Will, C.2    Knoblauch, A.3    Sharek, L.4    Von Der Mark, K.5    Burridge, K.6    Wixler, V.7
  • 27
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • P. Mundel, J. Reiser, B.A. Zúñiga Mejía, H. Pavenstädt, G.R. Davidson, W. Kriz, and R. Zeller Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines Exp Cell Res 236 1997 248 258
    • (1997) Exp Cell Res , vol.236 , pp. 248-258
    • Mundel, P.1    Reiser, J.2    Zúñiga Mejía, B.A.3    Pavenstädt, H.4    Davidson, G.R.5    Kriz, W.6    Zeller, R.7
  • 29
    • 0025818112 scopus 로고
    • Podocytes in glomerulus of rat kidney express a characteristic 44 KD protein
    • P. Mundel, P. Gilbert, and W. Kriz Podocytes in glomerulus of rat kidney express a characteristic 44 KD protein J Histochem Cytochem 39 1991 1047 1056
    • (1991) J Histochem Cytochem , vol.39 , pp. 1047-1056
    • Mundel, P.1    Gilbert, P.2    Kriz, W.3
  • 30
    • 0027378413 scopus 로고
    • Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues
    • S. Mundlos, J. Pelletier, A. Darveau, M. Bachmann, A. Winterpacht, and B. Zabel Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues Development 119 1993 1329 1341
    • (1993) Development , vol.119 , pp. 1329-1341
    • Mundlos, S.1    Pelletier, J.2    Darveau, A.3    Bachmann, M.4    Winterpacht, A.5    Zabel, B.6
  • 31
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • E.E. Sander, J.P. ten Klooster, S. van Delft, R.A. van der Kammen, and J.G. Collard Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior J Cell Biol 147 1999 1009 1022
    • (1999) J Cell Biol , vol.147 , pp. 1009-1022
    • Sander, E.E.1    Ten Klooster, J.P.2    Van Delft, S.3    Van Der Kammen, R.A.4    Collard, J.G.5
  • 32
    • 0037451803 scopus 로고    scopus 로고
    • GAPs galore! a survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
    • A. Bernards GAPs galore! a survey of putative Ras superfamily GTPase activating proteins in man and Drosophila Biochim Biophys Acta 1603 2003 47 82
    • (2003) Biochim Biophys Acta , vol.1603 , pp. 47-82
    • Bernards, A.1
  • 33
    • 27844604200 scopus 로고    scopus 로고
    • Rho GTPases and the control of cell behaviour
    • A. Hall Rho GTPases and the control of cell behaviour Biochem Soc Trans 33 Pt 5 2005 891 895
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 5 , pp. 891-895
    • Hall, A.1
  • 35
    • 0035943401 scopus 로고    scopus 로고
    • Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    • S. Etienne-Manneville, and A. Hall Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta Cell 106 2001 489 498
    • (2001) Cell , vol.106 , pp. 489-498
    • Etienne-Manneville, S.1    Hall, A.2
  • 36
    • 33744969296 scopus 로고    scopus 로고
    • Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    • K. Asanuma, E. Yanagida-Asanuma, C. Faul, Y. Tomino, K. Kim, and P. Mundel Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling Nat Cell Biol 8 2006 485 491
    • (2006) Nat Cell Biol , vol.8 , pp. 485-491
    • Asanuma, K.1    Yanagida-Asanuma, E.2    Faul, C.3    Tomino, Y.4    Kim, K.5    Mundel, P.6
  • 37
    • 0036080664 scopus 로고    scopus 로고
    • Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton
    • H. Yuan, E. Takeuchi, and D.J. Salant Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton Am J Physiol Renal Physiol 282 2002 F585 F591
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Yuan, H.1    Takeuchi, E.2    Salant, D.J.3
  • 38
    • 2542494061 scopus 로고    scopus 로고
    • Signaling at the slit diaphragm
    • T. Benzing Signaling at the slit diaphragm J Am Soc Nephrol 15 2004 1382 1391
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1382-1391
    • Benzing, T.1
  • 42
    • 80053328974 scopus 로고    scopus 로고
    • Actin dynamics and turnover in cell motility
    • K. Rottner, and T.E. Stradal Actin dynamics and turnover in cell motility Curr Opin Cell Biol 23 2011 569 578
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 569-578
    • Rottner, K.1    Stradal, T.E.2
  • 43
    • 33847013174 scopus 로고    scopus 로고
    • Cooperation of DEF6 with activated Rac in regulating cell morphology
    • T. Oka, S. Ihara, and Y. Fukui Cooperation of DEF6 with activated Rac in regulating cell morphology J Biol Chem 282 2007 2011 2018
    • (2007) J Biol Chem , vol.282 , pp. 2011-2018
    • Oka, T.1    Ihara, S.2    Fukui, Y.3
  • 45
    • 0036783544 scopus 로고    scopus 로고
    • CD2-associated protein directly interacts with the actin cytoskeleton
    • S. Lehtonen, F. Zhao, and E. Lehtonen CD2-associated protein directly interacts with the actin cytoskeleton Am J Physiol Renal Physiol 283 2002 F734 F743
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Lehtonen, S.1    Zhao, F.2    Lehtonen, E.3
  • 48
    • 0033621957 scopus 로고    scopus 로고
    • Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss
    • M.P. Coghlan, M.M. Chou, and C.L. Carpenter Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss Mol Cell Biol 20 2000 2880 2889
    • (2000) Mol Cell Biol , vol.20 , pp. 2880-2889
    • Coghlan, M.P.1    Chou, M.M.2    Carpenter, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.