-
1
-
-
0032835617
-
De novo design and structural characterization of proteins and metalloproteins
-
DeGrado, W. F., Summa, C. M., Pavone, V., Nastri, F. & Lombardi, A. De novo design and structural characterization of proteins and metalloproteins. Annu. Rev. Biochem. 68, 779-819 (1999).
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 779-819
-
-
Degrado, W.F.1
Summa, C.M.2
Pavone, V.3
Nastri, F.4
Lombardi, A.5
-
2
-
-
0032705432
-
Designed molecules that fold to mimic protein secondary structures
-
Stigers, K. D., Soth, M. J. & Nowick, J. S. Designed molecules that fold to mimic protein secondary structures. Curr. Opin. Chem. Biol. 3, 714-723 (1999).
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 714-723
-
-
Stigers, K.D.1
Soth, M.J.2
Nowick, J.S.3
-
3
-
-
0035471131
-
Design of folded peptides
-
Venkatraman, J., Shankaramma, S. C. & Balaram, P. Design of folded peptides. Chem. Rev. 101, 3131-3152 (2001).
-
(2001)
Chem. Rev.
, vol.101
, pp. 3131-3152
-
-
Venkatraman, J.1
Shankaramma, S.C.2
Balaram, P.3
-
4
-
-
17244370796
-
Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure
-
Tyndall, J. D. A., Pfeiffer, B., Abbenante, G. & Fairlie, D. P. Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chem. Rev. 105, 793-826 (2005).
-
(2005)
Chem. Rev.
, vol.105
, pp. 793-826
-
-
Tyndall, J.D.A.1
Pfeiffer, B.2
Abbenante, G.3
Fairlie, D.P.4
-
5
-
-
57149097169
-
Beta-peptidic peptidomimetics
-
Seebach, D. & Gardiner, J. Beta-peptidic peptidomimetics. Acc. Chem. Res. 41, 1366-1375 (2008).
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 1366-1375
-
-
Seebach, D.1
Gardiner, J.2
-
6
-
-
22144454687
-
Strategies for targeting protein-protein interactions with synthetic agents
-
Yin, H. & Hamilton, A. D. Strategies for targeting protein-protein interactions with synthetic agents. Angew. Chem. Int. Ed. 44, 4130-4163 (2005).
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 4130-4163
-
-
Yin, H.1
Hamilton, A.D.2
-
7
-
-
0031929547
-
Towards protein surface mimetics
-
Fairlie, D. P., West, M. L. & Wong, A. K. Towards protein surface mimetics. Curr. Med. Chem. 5, 29-62 (1998).
-
(1998)
Curr. Med. Chem.
, vol.5
, pp. 29-62
-
-
Fairlie, D.P.1
West, M.L.2
Wong, A.K.3
-
8
-
-
80052566586
-
Assessing helical protein interfaces for inhibitor design
-
Bullock, B. N., Jochim, A. L. & Arora, P. S. Assessing helical protein interfaces for inhibitor design. J. Am. Chem. Soc. 133, 14220-14223 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 14220-14223
-
-
Bullock, B.N.1
Jochim, A.L.2
Arora, P.S.3
-
10
-
-
0036888590
-
Complement in allergy and asthma
-
Gerard, N. P. & Gerard, C. Complement in allergy and asthma. Curr. Opin. Immunol. 14, 705-708 (2002).
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 705-708
-
-
Gerard, N.P.1
Gerard, C.2
-
11
-
-
35348928319
-
Anaphylatoxins: Their role in bacterial infection and inflammation
-
Haas, P.-J. & van, S. J. Anaphylatoxins: Their role in bacterial infection and inflammation. Immunol. Res. 37, 161-175 (2007).
-
(2007)
Immunol. Res.
, vol.37
, pp. 161-175
-
-
Haas, P.-J.1
Van, S.J.2
-
12
-
-
0021188922
-
Structure and function of the anaphylatoxins
-
Hugli, T. E. Structure and function of the anaphylatoxins. Springer Semin. Immunopathol. 7, 193-219 (1984).
-
(1984)
Springer Semin. Immunopathol.
, vol.7
, pp. 193-219
-
-
Hugli, T.E.1
-
13
-
-
67650736238
-
Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease
-
Masters, S. L., Simon, A., Aksentijevich, I. & Kastner, D. L. Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease. Annu. Rev. Immunol. 27, 621-668 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 621-668
-
-
Masters, S.L.1
Simon, A.2
Aksentijevich, I.3
Kastner, D.L.4
-
14
-
-
70349437186
-
Complement regulators and inhibitory proteins
-
Zipfel, P. F. & Skerka, C. Complement regulators and inhibitory proteins. Nat. Rev. Immunol. 9, 729-740 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 729-740
-
-
Zipfel, P.F.1
Skerka, C.2
-
15
-
-
70349320170
-
Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice
-
Mizutani, N., Nabe, T. & Yoshino, S. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J. Immunol. 183, 4039-4046 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 4039-4046
-
-
Mizutani, N.1
Nabe, T.2
Yoshino, S.3
-
16
-
-
75749157005
-
Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis
-
Hutamekalin, P. et al. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis. J. Pharmacol. Sci. 112, 56-63 (2010).
-
(2010)
J. Pharmacol. Sci.
, vol.112
, pp. 56-63
-
-
Hutamekalin, P.1
-
17
-
-
0034670027
-
Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxinshock
-
Kildsgaard, J. et al. Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxinshock. J. Immunol. 165, 5406-5409 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 5406-5409
-
-
Kildsgaard, J.1
-
18
-
-
74949125415
-
C3aR inhibition reduces neurodegeneration in experimental lupus
-
Jacob, A., Bao, L., Brorson, J., Quigg, R. J. & Alexander, J. J. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus 19, 73-82 (2010).
-
(2010)
Lupus
, vol.19
, pp. 73-82
-
-
Jacob, A.1
Bao, L.2
Brorson, J.3
Quigg, R.J.4
Alexander, J.J.5
-
19
-
-
70349126762
-
The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation
-
Mamane, Y. et al. The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes 58, 2006-2017 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 2006-2017
-
-
Mamane, Y.1
-
20
-
-
0022586255
-
Demonstration of anaphylatoxins C3a C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses
-
Takematsu, H., Ohkohchi, K. & Tagami, H. Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses. Br. J. Dermatol. 114, 1-6 (1986).
-
(1986)
Br. J. Dermatol.
, vol.114
, pp. 1-6
-
-
Takematsu, H.1
Ohkohchi, K.2
Tagami, H.3
-
21
-
-
62149135267
-
C3a mediates epithelialto-mesenchymal transition in proteinuric nephropathy
-
Tang, Z., Lu, B., Hatch, E., Sacks, S. H. & Sheerin, N. S. C3a mediates epithelialto-mesenchymal transition in proteinuric nephropathy. J. Am. Soc. Nephrol. 20, 593-603 (2009).
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 593-603
-
-
Tang, Z.1
Lu, B.2
Hatch, E.3
Sacks, S.H.4
Sheerin, N.S.5
-
22
-
-
3242776043
-
Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury
-
Proctor, L. M. et al. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Br. J. Pharmacol. 142, 756-764 (2004).
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 756-764
-
-
Proctor, L.M.1
-
23
-
-
84873472582
-
C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
-
Lim, J. et al. C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 27, 822-831 (2013).
-
(2013)
FASEB J.
, vol.27
, pp. 822-831
-
-
Lim, J.1
-
24
-
-
34047259526
-
Preservation of antimicrobial properties of complement peptide C3a, from invertebrates to humans
-
Pasupuleti, M. et al. Preservation of antimicrobial properties of complement peptide C3a, from invertebrates to humans. J. Biol. Chem. 282, 2520-2528 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2520-2528
-
-
Pasupuleti, M.1
-
25
-
-
33846378792
-
Antifungal activity of C3a and C3a-derived peptides against Candida
-
Sonesson, A. et al. Antifungal activity of C3a and C3a-derived peptides against Candida. Biochim. Biophys. Acta Biomembr. 1768, 346-353 (2007).
-
(2007)
Biochim. Biophys. Acta Biomembr.
, vol.1768
, pp. 346-353
-
-
Sonesson, A.1
-
26
-
-
0014900566
-
Anaphylatoxin inactivator of human plasma-Its isolation and characterization as a carboxypeptidase
-
Bokisch, V. A. & Mullereb, H. j. Anaphylatoxin inactivator of human plasma-its isolation and characterization as a carboxypeptidase. J. Clin. Invest. 49, 2427-2436 (1970).
-
(1970)
J. Clin. Invest.
, vol.49
, pp. 2427-2436
-
-
Bokisch, V.A.1
Mullereb, H.J.2
-
27
-
-
0344075949
-
C3a(desArg) does not bind to and signal through the human C3a receptor
-
Wilken, H.-C., Gotze, O., Werfel, T. & Zwirner, J. C3a(desArg) does not bind to and signal through the human C3a receptor. Immunol. Lett. 67, 141-145 (1999).
-
(1999)
Immunol. Lett.
, vol.67
, pp. 141-145
-
-
Wilken, H.-C.1
Gotze, O.2
Werfel, T.3
Zwirner, J.4
-
28
-
-
77954324612
-
Selective hexapeptide agonists and antagonists for human complement C3a receptor
-
erratum 8208
-
Scully, C. C. et al. Selective hexapeptide agonists and antagonists for human complement C3a receptor. J. Med. Chem. 53, 4938-4948 erratum 8208 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4938-4948
-
-
Scully, C.C.1
-
29
-
-
0035873782
-
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models
-
Ames, R. S. et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J. Immunol. 166, 6341-6348 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 6341-6348
-
-
Ames, R.S.1
-
30
-
-
34249699073
-
Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives
-
Denonne, F. et al. Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives. Bioorg. Med. Chem. Lett. 17, 3262-3265 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3262-3265
-
-
Denonne, F.1
-
31
-
-
34249341166
-
Discovery of new C3aR ligands. Part 1: Arginine derivatives
-
Denonne, F. et al. Discovery of new C3aR ligands. Part 1: Arginine derivatives. Bioorg. Med. Chem. Lett. 17, 3258-3261 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3258-3261
-
-
Denonne, F.1
-
32
-
-
0035814060
-
Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists
-
Grant, E. B. et al. Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists. Bioorg. Med. Chem. Lett. 11, 2817-2820 (2001).
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2817-2820
-
-
Grant, E.B.1
-
33
-
-
84875939215
-
Efficient chemical synthesis of human complement protein C3a
-
Ghassemian, A. et al. Efficient chemical synthesis of human complement protein C3a. Chem. Commun. 49, 2356-2358 (2013).
-
(2013)
Chem. Commun.
, vol.49
, pp. 2356-2358
-
-
Ghassemian, A.1
-
34
-
-
84874050615
-
Human c3a and c3a desarg anaphylatoxins have conserved structures in contrast to c5a and c5a desarg
-
Bajic, G., Yatime, L., Klos, A. & Andersen, G. R. Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg. Protein Sci. 22, 204-212 (2013).
-
(2013)
Protein Sci.
, vol.22
, pp. 204-212
-
-
Bajic, G.1
Yatime, L.2
Klos, A.3
Andersen, G.R.4
-
35
-
-
0019141474
-
Crystal structure analysis and molecular model of human C3a anaphylatoxin
-
Huber, R., Scholze, H., Paques, E. P. & Deisenhofer, J. Crystal structure analysis and molecular model of human C3a anaphylatoxin. Hoppe Seylers Z. Physiol. Chem. 361, 1389-1399 (1980).
-
(1980)
Hoppe Seylers Z. Physiol. Chem.
, vol.361
, pp. 1389-1399
-
-
Huber, R.1
Scholze, H.2
Paques, E.P.3
Deisenhofer, J.4
-
36
-
-
2342448367
-
Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin
-
Hugli, T. E. & Erickson, B. W. Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin. Proc. Natl Acad. Sci. USA 74, 1826-1830 (1977).
-
(1977)
Proc. Natl Acad. Sci. USA
, vol.74
, pp. 1826-1830
-
-
Hugli, T.E.1
Erickson, B.W.2
-
37
-
-
0031474771
-
Complement factors and their receptors
-
Ember, J. A. & Hugli, T. E. Complement factors and their receptors. Immunopharmacology 38, 3-15 (1997).
-
(1997)
Immunopharmacology
, vol.38
, pp. 3-15
-
-
Ember, J.A.1
Hugli, T.E.2
-
38
-
-
0033515630
-
Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function
-
Chao, T. H. et al. Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function. J. Biol. Chem. 274, 9721-9728 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9721-9728
-
-
Chao, T.H.1
-
39
-
-
0033600826
-
Ligand binding sites on guinea pig C3aR: Point and deletion mutations in the large extracellular loop and vicinity
-
Fukuoka, Y., Ember, J. A. & Hugli, T. E. Ligand binding sites on guinea pig C3aR: Point and deletion mutations in the large extracellular loop and vicinity. Biochem. Biophys. Res. Commun. 263, 357-360 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 357-360
-
-
Fukuoka, Y.1
Ember, J.A.2
Hugli, T.E.3
-
40
-
-
0032698758
-
Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor
-
Sun, J. Z. et al. Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor. Protein Sci. 8, 2304-2311 (1999).
-
(1999)
Protein Sci.
, vol.8
, pp. 2304-2311
-
-
Sun, J.Z.1
-
41
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu, B. L. et al. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330, 1066-1071 (2010).
-
(2010)
Science
, vol.330
, pp. 1066-1071
-
-
Wu, B.L.1
-
42
-
-
78649846386
-
Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure
-
Ruiz-Gomez, G., Tyndall, J. D. A., Pfeiffer, B., Abbenante, G. & Fairlie, D. P. Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chem. Rev. 110, PR1-PR41 (2010).
-
(2010)
Chem. Rev.
, vol.110
, pp. 1-41
-
-
Ruiz-Gomez, G.1
Tyndall, J.D.A.2
Pfeiffer, B.3
Abbenante, G.4
Fairlie, D.P.5
-
43
-
-
80955126943
-
Gaussian 09
-
Gaussian Inc., Wallingford, CT
-
Frisch, M. J. et al. Gaussian 09, Revision A.02 (Gaussian Inc., Wallingford, CT, 2009).
-
(2009)
Revision A.02
-
-
Frisch, M.J.1
-
44
-
-
84867312683
-
Recombinant acylation stimulating protein administration to C3(-/-) mice increases insulin resistance via adipocyte inflammatory mechanisms
-
Munkonda, M. N. et al. Recombinant acylation stimulating protein administration to C3(-/-) mice increases insulin resistance via adipocyte inflammatory mechanisms. PLoS One 7, e46883 (2012).
-
(2012)
PLoS One
, vol.7
, pp. 46883
-
-
Munkonda, M.N.1
-
45
-
-
33746217517
-
Concentration measurements by PULCON using X-filtered or 2D NMR spectra
-
Dreier, L. & Wider, G. Concentration measurements by PULCON using X-filtered or 2D NMR spectra. Magn. Reson. Chem. 44, S206-S212 (2006).
-
(2006)
Magn. Reson. Chem.
, vol.44
-
-
Dreier, L.1
Wider, G.2
-
46
-
-
0037939677
-
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; Activation following aggregation of FcepsilonRI or FcgammaRI
-
Kirshenbaum, A. S. et al. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 27, 677-682 (2003).
-
(2003)
Leuk. Res.
, vol.27
, pp. 677-682
-
-
Kirshenbaum, A.S.1
-
47
-
-
77956489794
-
-
eds John, E. C. et al.) (Chapter
-
Kuehn, H. S., Radinger, M. & Gilfillan, A. M. Current Protocols in Immunology. (eds John, E. C. et al.) (Chapter 7, Unit 7, 38, 2010).
-
(2010)
Current Protocols in Immunology.
, vol.7
, pp. 38
-
-
Kuehn, H.S.1
Radinger, M.2
Gilfillan, A.M.3
|