Heredity and lifestyle in the determination of between-subject Variation in thyroid hormone levels in euthyroid men

European Journal of Endocrinology

Volumn 169, Issue 6, 2013, Pages 835-844

  Roef, Greet ^a   Taes, Youri ^a   Toye, Kaatje ^a   Goemaere, Stefan ^a   Fiers, Tom ^a   Verstraete, Alain ^a   Kaufman, Jean Marc ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3,3',5' TRIIODOTHYRONINE; IODINE; LIOTHYRONINE; THYROGLOBULIN; THYROGLOBULIN ANTIBODY; THYROID HORMONE; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE; IODIDE PEROXIDASE; THYROXINE BINDING PROTEIN;

ADULT; AGE; ARTICLE; BODY MASS; BONE MASS; CROSS-SECTIONAL STUDY; EDUCATION; EUTHYROIDISM; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GENOTYPE; HEART RATE; HEREDITY; HORMONE URINE LEVEL; HUMAN; HUMAN EXPERIMENT; LIFESTYLE; MALE; NORMAL HUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; SIBLING; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; THYROID HORMONE BLOOD LEVEL; BELGIUM; BLOOD; EDUCATIONAL STATUS; METABOLISM; MIDDLE AGED; REFERENCE VALUE; THYROID FUNCTION TEST; THYROID GLAND;

ADULT; AGE FACTORS; BELGIUM; CROSS-SECTIONAL STUDIES; EDUCATIONAL STATUS; GENOTYPE; HEREDITY; HUMANS; IODIDE PEROXIDASE; LIFE STYLE; MALE; MIDDLE AGED; REFERENCE VALUES; SMOKING; THYROGLOBULIN; THYROID FUNCTION TESTS; THYROID GLAND; THYROID HORMONES; THYROTROPIN; THYROXINE; THYROXINE-BINDING PROTEINS; TRIIODOTHYRONINE; TRIIODOTHYRONINE, REVERSE;

EID: 84888224185     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0265     Document Type: Article

References (55)

1. Andersen S, Pedersen KM, Bruun NH & Laurberg P. Narrow individual variations in serum T (4) and T (3) in normal subjects: a clue to the understanding of subclinical thyroid disease. Journal of Clinical Endocrinology and Metabolism 2002 87 1068-1072. (doi:10.1210/jc.87.3.1068)
2. Roef GL, Taes YE, Kaufman JM, Van Daele C, De Buyzere ML, Gillebert TC & Rietzschel ER. Thyroid hormone levels within reference range are associated with heart rate, cardiac structure and function in middle-aged men and women. Thyroid 2013 23 947-954. (doi:10.1089/thy.2012.0471)
3. Roef G, Lapauw B, Goemaere S, Zmierczak HG, Toye K, Kaufman JM & Taes Y. Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young men. European Journal of Endocrinology 2012 167 719-726. (doi:10.1530/EJE-12-0447)
4. Murphy E, Gluer CC, Reid DM, Felsenberg D, Roux C, Eastell R & Williams GR. Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2010 95 3173-3181. (doi:10.1210/jc.2009-2630)
5. Roef G, Lapauw B, Goemaere S, Zmierczak H, Fiers T, Kaufman JM & Taes Y. Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass. European Journal of Endocrinology 2011 164 1027-1034. (doi:10.1530/EJE-10-1113)
6. Walsh JP. Setpoints and susceptibility: do small differences in thyroid function really matter? Clinical Endocrinology 2011 75 158-159. (doi:10.1111/j.1365-2265.2011.04036.x)
7. Hansen PS, Brix TH, Sorensen TI, Kyvik KO & Hegedus L. Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. Journal of Clinical Endocrinology and Metabolism 2004 89 1181-1187. (doi:10.1210/jc.2003-031641)
8. Hansen PS, Brix TH, Iachine I, Sorensen TI, Kyvik KO & Hegedus L. Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population. American Journal of Physiology. Endocrinology and Metabolism 2007 292 E765-E770. (doi:10.1152/ajpendo.00321. 2006)
9. Meikle AW, Stringham JD, Woodward MG & Nelson JC. Hereditary and environmental influences on the variation of thyroid hormones in normal male twins. Journal of Clinical Endocrinology and Metabolism 1988 66 588-592. (doi:10.1210/jcem-66-3-588)
10. 3 concentrations: a study of a large UK twin cohort. Clinical Endocrinology 2008 68 652-659. (doi:10.1111/j.1365-2265. 2007.03079.x)
11. Samollow PB, Perez G, Kammerer CM, Finegold D, Zwartjes PW, Havill LM, Comuzzie AG, Mahaney MC, Goring HH, Blangero J et al. Genetic and environmental influences on thyroid hormone variation in Mexican Americans. Journal of Clinical Endocrinology and Metabolism 2004 89 3276-3284. (doi:10.1210/jc.2003- 031706)
12. Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G et al. Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. American Journal of Human Genetics 2008 82 1270-1280. (doi:10.1016/j.ajhg.2008. 04.019)
13. Dayan CM & Panicker V. Novel insights into thyroid hormones from the study of common genetic variation. Nature Reviews. Endocrinology 2009 5 211-218. (doi:10.1038/nrendo.2009.19)
14. 4 levels. European Journal of Endocrinology 2011 164 781-788. (doi:10.1530/EJE-10-1130)
15. Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JR, Weedon MN, Singleton A, Hernandez D, Evans J et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. Journal of Clinical Endocrinology and Metabolism 2008 93 3075-3081. (doi:10. 1210/jc.2008-0397)
16. Panicker V, Wilson SG, Walsh JP, Richards JB, Brown SJ, Beilby JP, Bremner AP, Surdulescu GL, Qweitin E, Gillham-Nasenya I et al. A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. American Journal of Human Genetics 2010 87 430-435. (doi:10.1016/j.ajhg.2010.08.005)
17. Peeters RP, van Toor H, Klootwijk W, de Rijke YB, Kuiper GG, Uitterlinden AG & Visser TJ. Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects. Journal of Clinical Endocrinology and Metabolism 2003 88 2880-2888. (doi:10.1210/jc.2002-021592)
18. Peeters RP, van den Beld AW, Attalki H, Toor H, de Rijke YB, Kuiper GG, Lamberts SW, Janssen JA, Uitterlinden AG & Visser TJ. A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. American Journal of Physiology. Endocrinology and Metabolism 2005 289 E75-E81. (doi:10.1152/ajpendo.00571.2004)
19. Peeters RP, van der Deure WM & Visser TJ. Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases. European Journal of Endocrinology 2006 155 655-662. (doi:10.1530/eje.1.02279)
20. Shields BM, Freathy RM, Knight BA, Hill A, Weedon MN, Frayling TM, Hattersley AT & Vaidya B. Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. Journal of Clinical Endocrinology and Metabolism 2009 94 4608-4612. (doi:10.1210/jc.2009-1298)
21. Taylor PN, Panicker V, Sayers A, Shields B, Iqbal A, Bremner AP, Beilby JP, Leedman PJ, Hattersley AT, Vaidya B et al. A metaanalysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. European Journal of Endocrinology 2011 164 773-780. (doi:10.1530/EJE-10-0938)
22. van der Deure WM, Hansen PS, Peeters RP, Uitterlinden AG, Fenger M, Kyvik KO, Hegedus L & Visser TJ. The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins. Clinical Endocrinology 2009 70 954-960. (doi:10.1111/j.1365-2265.2008.03420.x)
23. Dora JM, Machado WE, Rheinheimer J, Crispim D & Maia AL. Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis. European Journal of Endocrinology 2010 163 427-434. (doi:10.1530/EJE-10-0419)
24. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA & Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension 2007 49 461-466. (doi:10.1161/01. HYP.0000256295.72185.fd)
25. Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD et al. Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. American Journal of Human Genetics 2009 84 418-423. (doi:10. 1016/j.ajhg.2009.02.004)
26. Peeters RP, van den Beld AW, van Toor H, Uitterlinden AG, Janssen JA, Lamberts SW & Visser TJ. A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans. Journal of Clinical Endocrinology and Metabolism 2005 90 256-263. (doi:10.1210/jc.2004-1301)
27. Peeters RP, van der Deure WM, van den Beld AW, van Toor H, Lamberts SW, Janssen JA, Uitterlinden AG & Visser TJ. The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clinical Endocrinology 2007 66 808-815. (doi:10.1111/j.1365-2265.2007. 02817.x)
28. Heemstra KA, Hoftijzer H, van der Deure WM, Peeters RP, Hamdy NA, Pereira A, Corssmit EP, Romijn JA, Visser TJ & Smit JW. The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density. Journal of Bone and Mineral Research 2010 25 1385-1391. (doi:10.1002/jbmr.27)
29. Bremner AP, Feddema P, Leedman PJ, Brown SJ, Beilby JP, Lim EM, Wilson SG, O'Leary PC & Walsh JP. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. Journal of Clinical Endocrinology and Metabolism 2012 97 1554-1562. (doi:10.1210/jc.2011-3020)
30. Mariotti S, Franceschi C, Cossarizza A & Pinchera A. The aging thyroid. Endocrine Reviews 1995 16 686-715.
31. Soldin OP, Goughenour BE, Gilbert SZ, Landy HJ & Soldin SJ. Thyroid hormone levels associated with active and passive cigarette smoking. Thyroid 2009 19 817-823. (doi:10.1089/thy.2009.0023)
32. Asvold BO, Bjoro T, Nilsen TI & Vatten LJ. Tobacco smoking and thyroid function: a population-based study. Archives of Internal Medicine 2007 167 1428-1432. (doi:10.1001/archinte.167. 13.1428)
33. De Pergola G, Ciampolillo A, Paolotti S, Trerotoli P & Giorgino R. Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clinical Endocrinology 2007 67 265-269. (doi:10.1111/j.1365-2265.2007.02874.x)
34. Bjergved L, Jorgensen T, Perrild H, Carle A, Cerqueira C, Krejbjerg A, Laurberg P, Ovesen L, Bulow PI, Rasmussen LB et al. Predictors of change in serum TSH after iodine fortification: an 11-year follow-up to the DanThyr Study. Journal of Clinical Endocrinology and Metabolism 2012 97 4022-4029. (doi:10. 1210/jc.2012-2508)
35. Haddow JE, McClain MR, Palomaki GE & Hollowell JG. Urine iodine measurements, creatinine adjustment, and thyroid deficiency in an adult United States population. Journal of Clinical Endocrinology and Metabolism 2007 92 1019-1022. (doi:10.1210/jc.2006-2156)
36. Soldin OP, Tractenberg RE & Pezzullo JC. Do thyroxine and thyroidstimulating hormone levels reflect urinary iodine concentrations? Therapeutic Drug Monitoring 2005 27 178-185. (doi:10.1097/01. ftd.0000149954.20089.0b)
37. Lapauw BM, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak HG, De Bacquer D & Kaufman JM. Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings. Journal of Bone and Mineral Research 2009 24 1075-1085. (doi:10.1359/jbmr.081260)
38. Taes Y, Lapauw B, Vanbillemont G, Bogaert V, De Bacquer D, Goemaere S, Zmierczak H & Kaufman JM. Early smoking is associated with peak bone mass and prevalent fractures in young, healthy men. Journal of Bone and Mineral Research 2010 25 379-387. (doi:10.1359/jbmr.090809)
39. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Andersen S, Rasmussen LB, Ovesen L & Jorgensen T. Estimation of iodine intake from various urinary iodine measurements in population studies. Thyroid 2009 19 1281-1286. (doi:10.1089/thy.2009. 0094)
40. Hanisch D, Dittmar M, Hohler T & Alt KW. Contribution of genetic and environmental factors to variation in body compartments - a twin study in adults. Anthropologischer Anzeiger 2004 62 51-60.
41. Panicker V, Wilson SG, Spector TD, Brown SJ, Kato BS, Reed PW, Falchi M, Richards JB, Surdulescu GL, Lim EM et al. Genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort. Journal of Clinical Endocrinology and Metabolism 2008 93 3519-3523. (doi:10.1210/jc.2007-2650)
42. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC & Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2005 90 3472-3478. (doi:10.1210/jc.2004-1977)
43. Grandone A, Perrone L, Cirillo G, Di Sessa A, Corona AM, Amato A, Cresta N, Romano T & Miraglia DG. Impact of the phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity. European Journal of Endocrinology 2011 166 255-260. (doi:10.1530/EJE-11-0703)
44. Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Masson G, He H, Jonasdottir A, Sigurdsson A, Stacey SN, Johannsdottir H et al. Discovery of common variants associated with low TSH levels and thyroid cancer risk. Nature Genetics 2012 44 319-322. (doi:10.1038/ng.1046)
45. Roef GL, Rietzschel ER, De Meyer T, Bekaert S, De Buyzere ML, Kaufman JM & Taes YE. Associations of rs4704397 in phosphodiesterase 8B with thyrotropin and thyroid hormone concentrations. Thyroid 2013 23 376-377. (doi:10.1089/thy. 2012.0519)
46. Atzmon G, Barzilai N, Surks MI & Gabriely I. Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. Journal of Clinical Endocrinology and Metabolism 2009 94 4768-4775. (doi:10.1210/jc. 2009-0808)
47. 4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study. Clinical Endocrinology 2008 68 175-181.
48. Sorensen HG, van der Deure WM, Hansen PS, Peeters RP, Breteler MM, Kyvik KO, Sorensen TI, Hegedus L & Visser TJ. Identification and consequences of polymorphisms in the thyroid hormone receptor a and b genes. Thyroid 2008 18 1087-1094. (doi:10.1089/thy.2008.0236)
49. Zhang X & Ho SM. Epigenetics meets endocrinology. Journal of Molecular Endocrinology 2011 46 R11-R32. (doi:10.1677/JME-10-0053)
50. Meisinger C, Ittermann T, Wallaschofski H, Heier M, Below H, Kramer A, Doring A, Nauck M & Volzke H. Geographic variations in the frequency of thyroid disorders and thyroid peroxidase antibodies in persons without former thyroid disease within Germany. European Journal of Endocrinology 2012 167 363-371. (doi:10.1530/EJE-12-0111)
51. Utiger RD. Effects of smoking on thyroid function. European Journal of Endocrinology 1998 138 368-369. (doi:10.1530/eje.0. 1380368)
52. Fisher CL, Mannino DM, Herman WH & Frumkin H. Cigarette smoking and thyroid hormone levels in males. International Journal of Epidemiology 1997 26 972-977. (doi:10.1093/ije/26. 5.972)
53. Moreno-Reyes R, Carpentier YA, Macours P, Gulbis B, Corvilain B, Glinoer D & Goldman S. Seasons but not ethnicity influence urinary iodine concentrations in Belgian adults. European Journal of Nutrition 2011 50 285-290. (doi:10.1007/s00394-010-0137-4)
54. Vandevijvere S, Mourri AB, Amsalkhir S, Avni F, Van Oyen H & Moreno-Reyes R. Fortification of bread with iodized salt corrected iodine deficiency in school-aged children, but not in their mothers: a national cross-sectional survey in Belgium. Thyroid 2012 22 1046-1053. (doi:10.1089/thy.2012.0016)
55. Andersen S, Pedersen KM, Pedersen IB & Laurberg P. Variations in urinary iodine excretion and thyroid function. A 1-year study in healthy men. European Journal of Endocrinology 2001 144 461-465. (doi:10.1530/eje.0.1440461)