ELOVL2 gene polymorphisms are associated with increases in plasma eicosapentaenoic and docosahexaenoic acid proportions after fish oil supplement

Genes and Nutrition

Volumn 9, Issue 1, 2014, Pages

  Alsaleh, Aseel ^a   Maniou, Zoitsa ^a   Lewis, Fiona J ^a   Hall, Wendy L ^a   Sanders, Thomas A B ^a   O'Dell, Sandra D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Docosahexaenoic acid; Eicosapentaenoic acid; Elongase; Fish oil; Single nucleotide polymorphism

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ELOVL2 GENE; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84888214980     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-013-0362-6     Document Type: Article

References (34)

1. Al-Hilal M, AlSaleh A, Maniou Z, Lewis FJ, Hall WL, Sanders TA, O'Dell SD, MARINA Study Group (2013) Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. J Lipid Res 54:542-551
2. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T et al (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41:47-55
3. Bays H (2006) Clinical overview of Omacor: a concentrated formulation of omega-3 polyunsaturated fatty acids. Am J Cardiol 98:71i-76i
4. Burdge GC (2006) Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 75:161-168
5. Caslake MJ, Miles EA, Kofler BM, Lietz G, Curtis P, Armah CK, Kimber AC, Grew JP, Farrell L, Stannard J, Napper FL, Sala-Vila A, West AL, Mathers JC, Packard C, Williams CM, Calder PC, Minihane AM (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Am J Clin Nutr 88:618-629
6. NCBI SNP database (2012). http://www.ncbi.nlm.nih.gov/projects/SNP/. Accessed Dec 2012
7. Delgado-Lista J, Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F (2012) Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr 107(2):S201-S213
8. Gaunt TR, Rodríguez S, Day IN (2007) Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics 8:428
9. Griffin MD, Sanders TA, Davies IG, Morgan LM, Millward DJ, Lewis F, Slaughter S, Cooper JA, Miller GJ, Griffin BA (2006) Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. Am J Clin Nutr 84:1290-1298
10. Grimble RF, Howell WM, O'Reilly G, Turner SJ, Markovic O, Hirrell S, East JM, Calder PC (2002) The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 76:454-459
11. Guillou H, Zadravec D, Martin PG, Jacobsson A (2010) The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res 49:186-199
12. Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes HW et al (2010) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42:137-141
13. Jump DB, Depner CM, Tripathy S (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res 53:2525-2545
14. Kotwal S, Jun M, Sullivan D, Perkovic V, Neal B (2012) Omega 3 Fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 5:808-818
15. Kromhout D, Giltay EJ, Geleijnse JM, Group Alpha Omega Trial (2010) n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 363:2015-2026
16. Lemaitre RN, Tanaka T, Tang W, Manichaikul A, Foy M, Kabagambe EK, Nettleton JA, King IB, Weng LC, Bhattacharya S et al (2011) Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet 7:e1002193
17. Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P (2000) Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J 350:765-770
18. Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, Kopchik JJ, Mukerji P, Huang YS (2002) Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids 37:733-740
19. Lepage G, Roy CC (1988) Specific methylation of plasma nonesterified fatty acids in a one-step reaction. J Lipid Res 29:227-235
20. Madden J, Williams CM, Calder PC, Lietz G, Miles EA, Cordell H, Mathers JC, Minihane AM (2011) The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. Annu Rev Nutr 31:203-234
21. Marchioli R, Silletta MG, Levantesi G, Pioggiarella R (2009) Omega-3 fatty acids and heart failure. Curr Atheroscler Rep 11:440-447
22. Minihane AM (2010) Fatty acid-genotype interactions and cardiovascular risk. Prostaglandins Leukot Essent Fatty Acids 82:259-264
23. Mozaffarian D, Wu JH (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58:2047-2067
24. Olano-Martin E, Anil E, Caslake MJ, Packard CJ, Bedford D, Stewart G, Peiris D, Williams CM, Minihane AM (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis 209:104-110
25. Pishva H, Mahboob SA, Mehdipour P, Eshraghian MR, Mohammadi-Asl J, Hosseini S, Karimi F (2010) Fatty acid binding protein-2 genotype influences lipid and lipoprotein response to eicosapentaenoic acid supplementation in hypertriglyceridemic subjects. Nutrition 26:1117-1121
26. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS (2012) Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 308:1024-1033
27. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M et al (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41:35-46
28. Sanders TA, Hall WL, Maniou Z, Lewis F, Seed PT, Chowienczyk PJ (2011) Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. Am J Clin Nutr 94:973-980
29. Standing Advisory Committee on Nutrition (SACN) (2004) Advice on fish consumption: risk and benefits. The Stationery Office (TSO), London
30. Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, Singleton A, Bandinelli S, Cherubini A, Arnett D et al (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet 5:e1000338
31. Tregouet DA, Garelle V (2007) A new JAVA interface implementation of THESIAS: testing haplotype effect in association studies. Bioinformatics 23:1038-1039
32. Tregouet DA, Escolano S, Tiret L, Mallet A, Golmard JL (2004) A new maximum likelihood algorithm for haplotype-based association analysis: the SEM algorithm. Ann Hum Genet 68:165-177
33. Trial Investigators ORIGIN, Bosch J, Gerstein HC, Dagenais GR, Díaz R, Dyal L, Jung H, Maggiono AP, Probstfield J, Ramachandran A et al (2012) n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 367:309-318
34. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K, EPA Japan lipid intervention study (JELIS) Investigators (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369:1090-1098