Clinical Overview of Omacor: A Concentrated Formulation of Omega-3 Polyunsaturated Fatty Acids

American Journal of Cardiology

Volumn 98, Issue 4 SUPPL. 1, 2006, Pages 71-76

  Bays, Harold ^a  

^a LOUISVILLE METABOLIC AND ATHEROSCLEROSIS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ARTICLE; BLEEDING; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG FORMULATION; DRUG INDICATION; DRUG PURIFICATION; DRUG SAFETY; DRUG TOLERABILITY; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; HYPERVITAMINOSIS; KIDNEY DYSFUNCTION; NEUROPATHY; PRIORITY JOURNAL;

CHOLESTEROL, HDL; CHOLESTEROL, LDL; CLINICAL TRIALS; DOCOSAHEXAENOIC ACIDS; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTRIGLYCERIDEMIA; VITAMIN E;

EID: 33747129220     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2005.12.029     Document Type: Article

References (22)

1. American Heart Association. Fish and omega-3 fatty acids [AHA Recommendation]. Available at: http://www.americanheart.org/presenter.jhtml?identifier=4632. Accessed January 27, 2006.
2. United States Department of Agriculture, Agricultural Research Service Nutrient Data Laboratory. Available at: http://www.nal.usda.gov/fnic/foodcomp/search/. Accessed January 27, 2006.
3. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction. results of the GISSI-Prevenzione trial. Lancet 354 (1999) 447-455
4. Grundt H., Nilsen D.W., Hetland O., Aarsland T., Baksaas I., Grande T., and Woie L. Improvement of serum lipids and blood pressure during intervention with n-3 fatty acids was not associated with changes in insulin levels in subjects with combined hyperlipidaemia. J Intern Med 237 (1995) 249-259
5. Eritsland J., Arnesen H., Gronseth K., Fjeld N.B., and Abdelnoor M. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 77 (1996) 31-36
6. Harris W.S., Ginsberg H.N., Arunakul N., Shachter N.S., Windsor S.L., Adams M., Berglund L., and Osmundsen K. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 4 (1997) 385-391
7. McKeone B.J., Osmundsen K., Brauchi D., Pao Q., Payton-Ross C., Kilinc C., Kummerow F.A., and Pownall H.J. Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. J Lipid Res 38 (1997) 429-436
8. Abe Y., El-Masri B., Kimball K.T., Pownall H., Reilly C.F., Osmundsen K., Smith C.W., and Ballantyne C.M. Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion. Arterioscler Thromb Vasc Biol 18 (1998) 723-731
9. Pownall H.J., Brauchi D., Kilinc C., Osmundsen K., Pao Q., Payton-Ross C., Gotto Jr. A.M., and Ballantyne C.M. Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins. Atherosclerosis 143 (1999) 285-297
10. Johansen O., Brekke M., Seljeflot I., Abdelnoor M., Arnesen H., and Coronary Angioplasty Restenosis Trial. N-3 fatty acids do not prevent restenosis after coronary angioplasty. results from the CART study. J Am Coll Cardiol 33 (1999) 1619-1626
11. Calabresi L., Donati D., Pazzucconi F., Sirtori C.R., and Franceschini G. Omacor in familial combined hyperlipidemia. effects on lipids and low density lipoprotein subclasses. Atherosclerosis 148 (2000) 387-396
12. Westphal S., Orth M., Ambrosch A., Osmundsen K., and Luley C. Postprandial chylomicrons and VLDLs in severe hypertriacylglycerolemia are lowered more effectively than are chylomicron remnants after treatment with n-3 fatty acids. Am J Clin Nutr 71 (2000) 914-920
13. Stalenhoef A.F., de Graaf J., Wittekoek M.E., Bredie S.J., Demacker P.N., and Kastelein J.J. The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertriglyceridemia. Atherosclerosis 153 (2000) 129-138
14. Durrington P.N., Bhatnagar D., Mackness M.I., Morgan J., Julier K., Khan M.A., and France M. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart 85 (2001) 544-548
15. Calabresi L., Villa B., Canavesi M., Sirtori C.R., James R.W., Bernini F., and Franceschini G. An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. Metabolism 53 (2004) 153-158
16. Kaminski W.E., Jendraschak E., Kiefl R., and von Schacky C. Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood 81 (1993) 1871-1879
17. Eritsland J., Arnesen H., Berg K., Seljeflot I., and Abdelnoor M. Serum Lp(a) lipoprotein levels in patients with coronary artery disease and the influence of long-term n-3 fatty acid supplementation. Scand J Clin Lab Invest 55 (1995) 295-300
18. Russo C., Olivieri O., Girelli D., Azzini M., Stanzial A.M., Guarini P., Friso S., De Franceschi L., and Corrocher R. Omega-3 polyunsaturated fatty acid supplements and ambulatory blood pressure monitoring parameters in patients with mild essential hypertension. J Hypertens 13 (1995) 1823-1826
19. Donadio Jr. J.V., Larson T.S., Bergstralh E.J., and Grande J.P. A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy. J Am Soc Nephrol 12 (2001) 791-799
20. US Department of Health and Human Resources and the US Environmental Protection Agency. What you need to know about mercury in fish and shellfish: 2004 EPA and FDA advice for: women who might become pregnant, women who are pregnant, nursing mothers, young children. Publication No. EPA-823-R-04-005. Available at: http://www.cfsan.fda.gov/∼dms/admehg3.html. Accessed January 27, 2006.
21. Solvay Healthcare Limited. Omacor Production. Solvay Public Omacor Website. Available at: http://www.Omacor.co.uk/pages/dykproduction.asp. Accessed January 27, 2006.
22. Omacor [prescribing information]. Liberty Corner, NJ: Reliant Pharmaceuticals, Inc; 2005. Available at: http://www.omacorrx.com/OMACOR/OMACOR_Prescribing_Information.pdf. Accessed April 7, 2006.