Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways

Toxicology and Applied Pharmacology

Volumn 273, Issue 2, 2013, Pages 390-400

  Kakehashi, Anna ^a   Hagiwara, Akihiro ^b   Imai, Norio ^b   Nagano, Kasuke ^c   Nishimaki, Fukumi ^d   Banton, Marcy ^e   Wei, Min ^a   Fukushima, Shoji ^a,f   Wanibuchi, Hideki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Daiyukai Research Institute for Medical Science   (Japan)

^c Nagano Toxicologic Pathology Consulting   (Japan)

^d Petroleum Energy Center   (Japan)

^e One Houston Center   (United States)

^f JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

8 OHdG; Apoptosis; Ethyl tertiary butyl ether; Liver tumors; Mode of action; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CARCINOGEN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C11; CYTOCHROME P450 2C6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DNA GLYCOSYLTRANSFERASE; DNA OXOGUANINE GLYCOSYLASE 1; ETHER DERIVATIVE; ETHYL TERTIARY BUTYL ETHER; HYDROXYL RADICAL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHENOBARBITAL; PREGNANE X RECEPTOR; PROTEOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HEPATOTUMORIGENICITY; HISTOPATHOLOGY; LIVER CARCINOGENESIS; LIVER CELL; LIVER HYPERTROPHY; MALE; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PROTEIN CONTENT; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

8-OHDG; APOPTOSIS; ETHYL TERTIARY-BUTYL ETHER; LIVER TUMORS; MODE OF ACTION; OXIDATIVE STRESS;

AIR POLLUTANTS; ANIMALS; CARCINOGENESIS; ETHYL ETHERS; LIVER NEOPLASMS; MALE; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RATS; RATS, INBRED F344; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84888206101     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.09.016     Document Type: Article

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