Ghrelin inhibits high glucose-induced PC12 cell apoptosis by regulating TLR4/NF-κB pathway

Inflammation

Volumn 36, Issue 6, 2013, Pages 1286-1294

  Liu, Xiaoyan ^a   Xiao, Qian ^a   Zhao, Kexiang ^a   Gao, Yuan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

ghrelin; high glucose; inflammation; PC12; TLR4 NF B pathway

Indexed keywords

GHRELIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; HORMONE ACTION; INFLAMMATION; INTRACELLULAR SIGNALING; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; BRAIN DISEASES, METABOLIC; CELL LINE; DIABETES COMPLICATIONS; GHRELIN; GLUCOSE; INFLAMMATION; NF-KAPPA B; PC12 CELLS; RATS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84888201169     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9667-2     Document Type: Article

References (31)

1. Biessels, G.J., I.J. Deary, and C.M. Ryan. 2008. Cognition and diabetes: a life span perspective. Lancet Neurology 7: 184-190.
2. Ferguson, S.C., A. Blane, J. Wardlaw, et al. 2005. Influence of early onset age of type 1 diabetes on cerebral structure and cognitive function. Diabetes Care 28: 1431-1437.
3. Perantie, D.C., J. Wu, J.M. Koller, et al. 2007. Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care 30: 2331-2337.
4. Hoffman, W.H., C.M. Artlett, W. Zhang, et al. 2008. Receptor for advanced glycation end products and neuronal deficit in fatal brain edema of diabetic ketoacidosis. Brain Research 1238: 154-162.
5. Francis, G.J., J.A. Martinez, W.Q. Liu, et al. 2008. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type 1 diabetic encephalopathy. Brain 131(Pt 12): 3311-3334.
6. Wu, R., M. Zhou, P. Das, et al. 2007. Ghrelin inhibits sympathetic nervous activity in sepsis. American Journal of Physiology. Endocrinology and Metabolism 293: E1697-E1702.
7. Wu, R., W. Dong, M. Zhou, et al. 2007. Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. American Journal of Respiratory and Critical Care Medicine 176: 805-813.
8. Cowley, M.A., R.G. Smith, S. Diano, et al. 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37: 649-661.
9. Lin, Y., K. Matsumura, M. Fukuhara, et al. 2004. Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension 43: 977-982.
10. Zhang, W., T.R. Lin, Y. Hu, et al. 2004. Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus. The Journal of Physiology 559: 729-737.
11. Navarro-González, J.F., and C. Mora-Fernández. 2008. The role of inflammatory cytokines in diabetic nephropathy. Journal of the American Society of Nephrology 19: 433-442.
12. Teng, W., L. Wang, W. Xue, and C. Guan. 2009. Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats. Mediators of Inflammation 2009: 473276.
13. Martin, T.F., and R.N. Grishanin. 2003. PC12 cells as a model for studies of regulated secretion in neuronal and endocrine cells. Methods in Cell Biology 71: 267-286.
14. Abid-Essefi, S., I. Baudrimont, W. Hassen, et al. 2003. DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by vitamin E. Toxicology 192: 237-248.
15. Pickup, J.C. 2004. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27(3): 813-823.
16. Spranger, J., A. Kroke, M. Mohlig, et al. 2003. Inflammatory cytokines and the risk to develop type2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetes 52: 812-817.
17. Thorand, B., H. Lowel, A. Schneider, et al. 2003. C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study. Archives of Internal Medicine 163: 93-99.
18. Lontchi-Yimagou, Eric, et al. 2013. Diabetes mellitus and inflammation. Current Diabetes Reports 13(3): 435-444.
19. Kempf, Kerstin, et al. 2006. Inflammation in metabolic syndrome and type 2 diabetes impact of dietary glucose. Annals of the New York Academy of Sciences 1084: 30-48.
20. Sima, Anders A.F., Weixian Zhang, Christian W. Kreipke, et al. 2009. Inflammation in diabetic encephalopathy is prevented by C-peptide. Rev Diabet Stud 6(1): 37-42.
21. Sharifi, Ali M., Seyed Hadi Mousavi, and Mona Farhadi. 2007. Study of high glucose-induced apoptosis in PC12 cells: role of Bax protein. J Pharmacol Sci 104: 258-262.
22. Miao, Y., Q. Xia, Z. Hou, et al. 2007. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochemical and Biophysical Research Communications 359: 795-800.
23. Ma, Louyan, Dongmin Zhang, Yong Tang, et al. 2011. Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats. Alzheimer Disease and Associated Disorders 25: 352-363.
24. Dolgor, B., P. Kalpesh, and D.T. Dennis. 2011. The effects of ghrelin on inflammation and the immune system. Molecular and Cellular Endocrinology 340: 44-58.
25. Madison, L.D., J.M. Scarlett, P. Levasseur, et al. 2008. Prostacyclin signaling regulates circulating ghrelin during acute inflammation. Journal of Endocrinology 196: 263-273.
26. Dixit, V.D., et al. 2009. Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation. Blood 113(21): 5202-5205.
27. Wei, G.L., et al. 2004. Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells. Circulation 109: 2221-2226.
28. Cletus, C., et al. 2011. Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve. Shock 35(3): 258-265.
29. Talat, W., et al. 2008. Exogenous ghrelin modulates release of pro- and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143(3): 334-342.
30. Downes, C.E., and P.J. Crack. 2010. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS. British Journal of Pharmacology 160: 1872-1888.
31. Racke, M.K., and P.D. Drew. 2009. Toll-like receptors in multiple sclerosis. Current Topics in Microbiology and Immunology 336: 155-168.